The Interview

Dr Aaron Motsoaledi, South African health minister: The fight against HIV/AIDS continues.

23 min
Feb 9, 20262 months ago
Listen to Episode
Summary

Dr. Aaron Motsoaledi, South Africa's health minister, discusses how his country is responding to the withdrawal of US HIV/AIDS funding by building domestic capacity and self-sufficiency. He outlines emergency funding measures, research partnerships with the Bill and Melinda Gates Foundation, and new prevention programs including the rollout of Lenacapavir to combat HIV/AIDS.

Insights
  • US aid cuts to global health programs create immediate operational chaos for NGOs and healthcare systems, forcing countries to rapidly mobilize domestic resources and restructure funding models
  • South Africa is pivoting from donor-dependent vertical HIV programs to integrated, domestically-funded universal health coverage (NHI) as a long-term sustainability strategy
  • Generic drug manufacturing through voluntary licensing agreements is critical to scaling HIV prevention and treatment in low-income countries at affordable prices
  • Research conducted in high-burden countries like South Africa benefits global pharmaceutical companies and developed nations more than the host country, creating equity concerns
  • Conditional foreign aid tied to specific programs creates operational friction and prevents countries from aligning health interventions with national priorities
Trends
Shift from donor-dependent to domestically-funded health systems in developing nationsIncreased reliance on generic drug manufacturing and voluntary licensing to reduce treatment costsIntegration of vertical disease programs into universal health coverage frameworksGrowing emphasis on African self-sufficiency and reduced dependence on Western aidGeopolitical weaponization of health aid through conditional funding and policy requirementsPublic-private partnerships with foundations (Gates, Wellcome) replacing government aidClinical trial burden concentrated in high-disease-burden countries with limited local benefitEmergency appropriations and bridge funding as stopgap measures for healthcare disruptions
Topics
US Foreign Aid Withdrawal and PEPFAR Funding CutsHIV/AIDS Treatment Scale-Up and ARV DistributionUniversal Health Coverage (National Health Insurance - NHI)Lenacapavir Prevention Program RolloutGeneric Drug Manufacturing and Voluntary LicensingHIV Research Funding and Clinical TrialsTB Screening and Treatment ProgramsData Capture Infrastructure for HIV ProgramsDonor Dependency and Health System SustainabilityAmerica First Global Health PolicyInternational Health Solidarity vs. Self-SufficiencyNGO Funding and Program IntegrationPharmaceutical Pricing and Access95-95-95 UNAIDS Treatment TargetsHealth System Resilience to Geopolitical Shocks
Companies
Gilead Sciences
Manufactures Lenacapavir, the expensive HIV prevention drug being negotiated for lower-cost distribution in South Africa
Bill and Melinda Gates Foundation
Providing $200 million in research funding to South Africa matched by Treasury, plus securing voluntary licenses for ...
Wellcome Trust
Co-funding $200 million research initiative with Gates Foundation to prevent HIV research collapse in South Africa
Global Fund
International organization established to fight HIV, TB, and malaria; negotiated 2 million doses of Lenacapavir for l...
Hetero Pharmaceuticals
Received voluntary license from Bill and Melinda Gates Foundation to manufacture generic Lenacapavir at reduced cost
Dr. Reddy's Laboratories
Partnered with Clinton Health Access Initiative to manufacture generic Lenacapavir at $40 per dose starting next year
Clinton Health Access Initiative
Led by former US President Bill Clinton; negotiating generic manufacturing partnerships for affordable HIV prevention...
South African Medical Research Council
Receives emergency funding to distribute research grants among institutions conducting HIV/AIDS research
UNAIDS
Established the 95-95-95 treatment target framework that South Africa uses to measure HIV program progress
USAID
US foreign aid agency whose funding cuts to HIV programs created operational disruptions across South Africa's health...
People
Dr. Aaron Motsoaledi
South Africa's health minister discussing country's response to US aid cuts and HIV/AIDS treatment strategy
Winnie Byanyima
Head of UNAIDS who warned of devastating consequences from sudden US foreign aid withdrawal
Donald Trump
US President whose order to freeze foreign aid for 90 days triggered global HIV response funding crisis
Bill Clinton
Former US President heading Clinton Health Access Initiative negotiating generic drug manufacturing deals
George W. Bush
Former US President who established PEPFAR in 2003, the largest commitment by any nation to address a single disease
Quotes
"This is a matter of life and death"
Major HIV charity representativeEarly in episode discussing US aid freeze impact
"The sudden withdrawal of life-saving support is having a devastating impact across countries, particularly Africa, but even in Asia and Latin America"
Winnie Byanyima, UNAIDSMid-episode
"When I call for universal health coverage, which we call NHI, is a call for self-sufficiency, that local resources must be mobilized so that you don't depend on anybody"
Dr. Aaron MotsoalediCore policy discussion
"We must think about bringing it to an end. And all our programs are moving towards that, to bring HIV AIDS to an end"
Dr. Aaron MotsoalediProgram strategy section
"There was no chance of starting with 6 million. We started with one and went upwards"
Dr. Aaron MotsoalediDiscussing incremental program rollout approach
Full Transcript
This BBC podcast is supported by ads outside the UK. It's time to see what you can accomplish with Shopify by your side. So, we can now listen to your podcast. Do not make that journey. Being born in America, feeling American, but having people treat me like I'm not. We're more popular than populism. For this interview, I met Dr. Aaron Motualedi, South Africa's health minister in Pretoria. Dr. Motualedi has been at the centre of the country's public health response for more than a decade. A medical doctor by training, he first took on the health portfolio in 2009, overseeing the world's largest HIV treatment programme. A year ago, cuts to US aid, including USAID funding, sent shockwaves through the global HIV response community. This is a matter of life and death, the words of a major HIV charity. In response to Donald Trump's order to freeze US foreign aid for 90 days, the decision has left refugee camps and emergency hospital clinics around the world in a real state of uncertainty. This 90 day halt to nearly all existing and new foreign aid, sending shockwaves across those organisations delivering humanitarian assistance, leaving a trail of chaos and confusion about whether people. I mean, what one example is PEPFAR, which is a huge programme that is administered by the State Department to try and suppress the HIV and AIDS transmission. I mean, I spoke to one former USAID official who said that they were literally contractors, clinics, you know, the parts signed up to this program, literally told they couldn't distribute the HIV medications and clinics were being shuttered. Now, again, at the time, the head of UNAIDS, Winnie Biannima, warned of the consequences. It is reasonable for the United States to want to reduce its funding over time. But the sudden withdrawal of life-saving support is having a devastating impact across countries, particularly Africa, but even in Asia and Latin America. Of course, it's going to cost many lives and needs to be reversed quickly. We urge for a reconsideration and an urgent restoration of life-saving services. Dr Motwale-Di responded by calling the cuts a wake-up call for Africa, arguing the continent would need to rely less on donors and take greater responsibility for its own health system. Now a year on, he reflects on what's changed, how South Africa is filling the funding gap and what the future looks like for HIV and AIDS treatment and research. It's also clear that global health cannot be tackled alone. When I call for universal health coverage, which we call NHI, is a call for self-sufficiency, that local resources must be mobilized so that you don't depend on anybody. Of course, we won't do away with international solidarity, like organizations like the Global Fund, which has been established to fight HIV, HIV, HIV and malaria. We can't claim that will be on our own, specifically because health is very much globally interconnected than many sectors. And pandemics do not know borders. I'm sure you are aware of that. So it's in the interest of the whole world to work together. So even though we say we want to be self-sufficient, but we don't think global solidarity must be dropped. Because if it gets dropped, the world will be in trouble. Welcome to the interview from the BBC World Service, Dr Aaron Motwaledi. Well, we have got no option but to hit the wake-up call. That is why a few months later, the minister, through Section 16 of the Public Finance Management Act, provided emergency funding, a stop-gap measure, which coincidentally, you interviewed me, when only two days ago, Parliament went to endorse what the minister's done in terms of the laws of the country. The parliament debated that special appropriation bill, and they passed it, and they believed it was necessary. But they also emphasized what I said, that this is a wake up call not to depend on anybody. And at any rate, you are aware that the U.S. has moved. There's no chance of them going back. They have adopted a new policy called America First Global Health Policy, where countries are supposed to sign with the U.S. to provide them with two very important issues, which I believe, frankly speaking, no nation on earth that respect itself should accede to that they will get their pathogen if there's any pandemic or epidemic in their area if there's any outbreak and they'll also provide them with a genome for life but the u.s is going to give them money for five years you are aware that the first country to sign was kenya the president signed but parliament did not support that none of that And they went to court and the court reversed that And that a new deal So there no going back That emergency funding that you mentioned that was implemented last year by the finance minister, right? What kind of was it meant to deal with? And has anything been put in place since then to ensure more long-term provisions in health? Well, it was emergency funding, which means the Minister of Finance is going to read the budget speed sometimes in February. He needs to make it permanent, no longer as emergency funding. Yes, that emergency funding was R750 million. Part of the money went to help research institutions via the South African Medical Research Council, and most of the money went to provinces to fill up the gaps, like for instance, one of the glaring weaknesses that we experienced was data capturers. People who captured data of who tested for HIV AIDS, who went to do viral loading and all that. That became a very big weakness because most of the data capturers were the ones who were paid for from PEPFA. So provinces have hired their own data capturers to make sure that we're hitting the call of self-sufficiency. Five provinces have already completed, only four are left, and they'll be completing before the end of this month. So the funding has gone towards things like data capture, for instance, and research and funding. Yes, I'm just giving an example of the issues that were very prominent, you know. But they also hired other staff members like lay counsellors, etc., etc. One of the country's leading research experts told us that in terms of HIV research, South Africa is now in a worse position now than it was when it was funded by the US. What do you say to that? Well, if a research institution was depending on the US for their research, they will be worse off, obviously, if that research is withdrawn. So they might be right. But what happened is the Bill and Melinda Gates Foundation said they will help by contributing 100 million rands. and the Wellcome Trust also joined it. And they said they will do so to fund research in South Africa, provided for every $100 million they contribute. Treasury contributes $200 million. And our Treasury agreed, agreed. So there's going to be $600 million provided for, by $400 million from our Treasury and $200 million from the Bill and Melinda Gates Foundation and the Wellcome Trust. And the Treasury agreed. Part of this money that was appropriated two days ago is part of that research to make sure that research does not collapse in the country. The U.S.'s NIH, the National Institute of Health, says they will continue to help with existing research. But how will the government ensure you've talked about some money that you're going to match to the Bill and Melinda Gates Foundation and others? How will you ensure that new research projects can be started? Because South Africa is the leader when it comes to HIV research. Well, as I said, that money was given to South African Medical Research Council to distribute it among researchers and academic institutions which are doing research. We're not dictating to them what to do. We just said we'll try to give funding. And now you can imagine this funding, as I said, was a stopgap measure. We must find a way to continue funding our own research. But having said so, I need to add, the research that is happening in South Africa on HIV AIDS does not benefit South Africa. I'm sure you must know that it's going to benefit the whole world, especially the U.S. pharmaceutical companies. We are busy with research now for HIV vaccine, which we believe will be available in two years' time. You know, in its final stages of clinical research, it needed 20,000 people. 13,000 are provided by South Africa alone. And there are seven other countries globally which are providing people for that research. While the vaccine... People who are being tested, they're participating in the trial. Yes, yes. And our own researchers are also involved. While that vaccine becomes available, it's not available for South Africa. And in fact, the pharmaceutical companies that are going to manufacture it are likely to be American pharmaceutical companies. So it should not give an impression that when research is done here, it's done for South Africa, it's done for the whole world. The reason that it's done in South Africa specifically is because we have got material for that research, because we have got the highest HIV AIDS load in the country. We've got the highest TB load in the country, et cetera, et cetera. So what are you doing to convince stakeholders like the US or other people around the world that it's worth investing in this research in South Africa? Can any human being convince, Tam? You know, you are asking me to convince a lion to become a vegetarian. It's a very difficult job. There's a six-month bridge for Pep Farm until March to support some of the HIV work being done here. But it's not clear if it's going to be extended. What will you do if the U.S. decides not to extend it? It won't be extended. I'm quite sure of that. But I don't think, fairly speaking, I may sound maybe ungrateful, but I don't think it will be desirable for it to be extended. I spent four hours with my staff. It's really a big mess. We want to integrate HIV AIDS project and move from vertical, you know, programs. Now, that money is available, but it's not fitting in with what the country is doing at the present moment. We try to plead, but it's not very clear how to use that. For instance, that money is not given to the state. It's given to NGOs directly, right, up to the end of March. Now, we don't know what's going to happen after March. But what we do know is that if anything wrong happens, they don't continue. Those NGOs are going to rush to us. We are unable to prepare for the future because we actually don't know where in the dark nobody is telling us. So it is funding it is help but it also problematic because it not in fitting in with our programs When a funder helps you they must come and say what do you need Where can we help They can't come and say, look, I'll only do this for you and I can't do that. And I don't care about what you think and about your programs. It becomes very complicated. So then what do you do if this funding isn't meeting your needs right now? I know you said you'll match the contributions by the Bill and Melinda Gates Foundation. You said there's been money coming in from the Wellcome Trust. But long term, what can South Africa do to make sure that it funds the projects it needs in the way that it needs? Well, that's exactly the homework which we've given to Treasury. As I've told you, the Minister of Finance is going to lead the budget now. It might not be immediately in this financial year because the budgeting process starts about eight months in advance, if I may put it that way. But going forward, the minister will have to make sure that we become self-sufficient. And that's exactly what parliament was also emphasizing. By the way, this is also what I've been emphasizing when I called for universal health coverage, which we call NHI. It's a call for self-sufficiency, that local resources must be mobilized so that you don't depend on anybody. Of course, we won't do away with international solidarity, like organizations like the Global Fund, which has been established to fight HIV, AIDS, TB, and malaria. We can't claim that will be on our own, specifically because health is very much globally interconnected than many sectors. And pandemics do not know borders. I'm sure you are aware of that. So it's in the interest of the whole world to work together. So even though we say we want to be self-sufficient, but we don't think global solidarity must be dropped because if it gets robbed, the world will be in trouble. The Treasury funding that you mentioned, am I right in thinking that it's only at the moment valid for one year? It's an emergency funding. Emergency funding cannot last for more than that. It was an emergency funding just for that period. And Parliament passed it as such. So what guarantees that you have that beyond that period of a year, there's still going to be funding there? No, no, no. That's why I'm saying it's the homework that Treasury needs to do. We presented that to the Minister of Finance during the budgetary process. We're waiting to hear from him. He is painfully aware and he even told Parliament that, yes, this was emergency funding just for now. And so he's painfully aware that going forward, something needs to be done. You're listening to the interview from the BBC World Service. Starting a business can be overwhelming. You're juggling multiple roles. Designer, marketer, logistics manager. All while bringing your vision to life. 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Since its creation, the US has invested over $110 billion in the global HIV and AIDS response, saving 26 million lives. But following the abrupt end of that funding, Dr. Mottualedi told me in an interview at the time that his country needed to step up. A year on in our conversation, he was open about what still needed to be done. But he was also keen to talk about what he sees as success stories. One of them is Lena Kapovir, a drug which offers almost total protection from HIV, which is to be made available to low and middle income countries at a much cheaper price by 2027. OK, let's return to my conversation with Dr. Aaron Matsualedi. When you were health minister previously under President Jacob Zuma, you kind of spearheaded the distribution of HIVs, the purchase of HIVs across South Africa. How do you feel about that situation now? No, it's going very strong. In fact, we are accelerating it because I have said and I'm still saying that South Africans must not accept and get used to the idea that we are going to live with a pandemic called HIV AIDS forever. We must think about bringing it to an end. And all our programs are moving towards that, to bring HIV AIDS to an end. And in this regard, we have launched three very, very important programs. The first one, which we launched on the 25th of February, is what we call 1.1 million clues that gap campaign. You might be well-versed with the UNAIDS formula to end HIV AIDS as a global health threat in what's called 95-95-95. I'm sure you know that. In South Africa, we are at 96, 79, and 94, meaning the weakness is the middle 95, whereby instead of 95% of people who are positive being on ARVs, we only have 79. We calculated how many people will make us reach the 95. It's 1.9 million people which we are looking for. And we launched that campaign called 1 Million Close the Gap campaign We already found the substantial number of them Bring them back to treatment That the first program The second program is the Lena Kapova which is coming We are hoping to launch it. And we are taking it so seriously. We want it to be launched by the president himself, not even by me. The Lena Kapova program to prevent HIV and AIDS. We've also launched by the deputy president of the country. we launched on World TB Day on the 24th of March last year, a program to screen 5 million people for TB and put those who are found to be positive on TB. So we are actually running them simultaneous. So those are some of the things that we are really doing to bring an end. I know you said you're waiting on the president to launch the Lenna Kapovir program. He's waiting for us. Oh, right. So when would you like to start rolling it out? He's waiting for us to give him a date. He's waiting for us. He's very enthusiastic. I've already spoken to him. No, no, we're still making... We want to launch it in the first quarter of the year. Yeah. Do you think there's enough of the medicine to be distributed across South Africa? Because an expert we spoke to doesn't think there's enough. For Lena Kapova? Look, I'm sure you are aware that Lena Kapova, which is manufactured by an American company called Gilead, is very expensive, extremely so. But the global fund went to negotiate 2 million doses. And South Africa has been provided for 488 people. So we know how many people we can provide in the first year. We're not fooling ourselves. It's 488 people because it's a six-monthly dose. 408,000 or 400 and 800? 488,000. Yes, which means you multiply the doses by two because we are going to give two doses. which means we have got more than 900 doses. Those will go for the whole year. We've already selected only 350 clinics where that will happen. And remember, we have got more than 3,000 clinics. So it's only 10% of what we have. Then next question will be what happens going forward. During the United Nations General Assembly in the U.S., two very important things happened. The Clinton Health Access Initiative, headed by the former president of the U.S., Bill Clinton, came together with the VETS-RHI, our own research institution here, together with an institution called Dr. Raynes, whereby a generic is going to be manufactured by Dr. Raynes Laboratories, which will now cost $40, no longer $28, which was original. $40 per dose, and that will only become available, I believe, next year. The second thing that happened is that the Bill and Melinda Gates Foundation did the same thing with another pharmaceutical company called Hetero, where they were given what you call voluntary licenses. I'm sure you are well-versed with the idea of voluntary license. Ordinarily, when a pharmaceutical company has done research and come up with a new product, under the global rules, they've got 20 years of intellectual property protection. That means for 20 years, they're the only ones who can manufacture that program. I mean, that product and sell it for whatever amount. But now, science has prevailed. Voluntary licenses have been given, I think, to about seven pharmaceutical companies. So is your plan then to buy some of these generic versions of Lenacapavir and distribute them? Of course, of course. We are fighting HIV AIDS through generics. At the moment, the reason that we are able to put close to 6 million people on ARVs is because we are using generics manufactured mostly in India. With originator drugs, no country can afford that. Maybe the US itself. at least a year for some of these generics to become available. So what happens? You said you've got enough doses for just over 400,000 people. Millions of people have HIV in the US, in South Africa. What happens to them? It's doses for 488 people. Yeah. We're going to start with those. There's no program that started 100% anywhere in the world. Even now, we are running the biggest HIV AIDS program in the whole world, where 6 million people are on ARVs. There was no chance of starting with 6 million. We started with one and went upwards. When I arrived in health in 2009, only 10% of our facilities were providing ARVs. Now it's 100. So you always start bit by bit. And as I already said to you, we have identified 350 clinics where we're going to start. That is the beginning because the Chinese said a journey of a thousand miles start with the first step. So we are taking the first steps. Thanks for listening to The Interview. For more compelling conversations, search for The Interview wherever you get your BBC podcasts. 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