Hey, Science Quickly fans, Rachel here. If you love our show, I want to tell you about another podcast you should definitely be listening to, Science Friday. Science Friday and Science Quickly definitely share a lot of podcast DNA, mostly because Science Friday was the first science show I ever listened to, and I love it so much that I've actually appeared as a guest host on the show. But even if you're a longtime fan like me, you might not realize that Science Friday isn't just for Fridays anymore. Every day, the Sci-Fi team puts the latest science news under the microscope, from the origin of the universe to AI news you can actually use to the science of heavy metal screams. Just like Science Quickly, Science Friday stokes your curiosity and pulls back the curtain on some of the most interesting science happening today. So give Science Friday a listen wherever you get your podcasts. For Scientific American Science Quickly, I'm Rachel Feltman. Today we're doing a deep dive on an extremely hot topic, peptides. Hype around these basic chemical building blocks has infiltrated social media feeds and congressional hearings alike. To hear some folks tell it, various peptides can be used to solve just about any problem a human body could have. But the science on that is far from settled. And in the meantime, the ready availability of gray market peptides could put people in danger. To help us understand why influencers seem so keen to inject themselves with dubious substances is Victoria Song, a senior reviewer at The Verge who writes The Optimizer newsletter. Thanks so much for coming on to chat today. Yeah, thanks for having me. So let's start by talking about what peptides are and why it seems like they've been everywhere lately. Yeah, so a peptide is a building block of a building block. So proteins are made of amino acids and peptides are just these short chains of amino acids. We've known about them for decades, but they are starting to gain a lot of traction in the biohacking community in Silicon Valley. And, you know, wellness influencers and fitness influencers have been kind of touting them as a new miracle cure-all for anything ranging from muscle aches to losing weight to skincare. So that's a big reason why you see a lot of talk about peptides these days. Yeah. And GLP-1 is a peptide, right? Yes. So the P in GLP stands for peptide. The whole thing is glucagon-like peptide. One, GLP use has also made people a lot more comfortable with the concept of just injecting their own medications, which a lot of these peptides that people are buying online, they are in this powder form that they have to reconstitute with sterile water and then buy syringes off of Amazon and inject them into themselves. Yeah. And what you're seeing people do online is different from like mainstream prescribed use of GLP-1s. But first, you went down a little bit of a rabbit hole with a peptide that a lot of people refer to as GLP-3. So could you tell us a little bit about that, how you got interested and what you found out? Yeah. So one of my editors messaged me and he was like, oh my God, the GLPs, they're iterating like iPhones. There's a GLP3. And I was kind of like, what do you mean GLP3? The official name for a GLP3 is retitrutide. Retatrutide is currently under phase three FDA clinical trials by Eli Lilly. It is a triple agonist, which means it works on three different pathways. And very, very early study results show that it's even more effective than trisepatide, which is the Zetbound and the Manjaros. And so you have a lot of these fitness influencers procuring gray market, which means they're not illegal sources. They're in this gray area of Reditru Tide. I was able to procure one off of a TikTok link from an influencer with an influencer code. It cost me about $130. And I got a little vial of something called Reditru Tide shipped to my house. And it's a little vial full of powder. And you mix it up with bacteriostatic or sterile water. And you can look up the dosage from other influencers online and peptide calculators online. and then you inject it, no prescription necessary. And it was like a strange experience because this is not an approved weight loss drug This is something that is currently being studied for efficacy and safety And while the results are promising Eli Lilly is not likely to be done with trials until sometime in late 2026. So I had procured this vial off the internet in like late 2025. These kind of gray market dubiously sourced peptides, they are usually sold as quote unquote research only. And it's all across the sites where it's just like, Wink, wink. Don't use this for human consumption. This is for research, lab-grade materials only. But it's sort of like this legal gray area because the people who are selling these, they know that people are using them. And when you watch influencers talk about it, they're not necessarily calling it Reda True Tide. They call it GLP-3 or Reda or Ratatouille to get around the social media kind of sensors where they get taken down for promoting an unapproved drug. But it is something that is happening very widely in Silicon Valley. there are things called peptide parties where you see a lot of like tech startup founders who are just injecting a bunch of different gray area peptides and they're just kind of biohacking and microdosing and coming up with their own mixes and matches from sometimes legitimate compound pharmacies, sometimes from very not legitimate compound pharmacies. And it's taking an extreme treatment, which is like an injection, which is invasive that has now become more normalized. And treating it like a multivitamin. And we're seeing a lot of that now. Yeah. You know, you mentioned compounding pharmacies. I would love it if you could just explain for our listeners how a standard compounding pharmacy is different from this sort of gray market approach. Because like you said, the availability of GLP-1s through compounding pharmacies sort of normalized for people the idea that you might get sent something in the mail and inject it. But this is very different. Yeah. So generally, if you go to your regular pharmacy, you get the standard formulation of a drug or a pill. But there are people out there who may not be able to take those because they have an allergy to a preservative in the pill or there's just something that they can't, for whatever reason, use the standard formulation for. And so then their doctor will refer them to a compounding pharmacy that will mix it for them or make the drug for them custom. And these compounding pharmacies, they usually, they refer to something called a monograph, which is like a little recipe for these pharmacists to use the actual safe version of this drug to make for people. And for a while, there was a shortage of GLP-1 drugs. And so compounding pharmacies were then authorized by the FDA to make GLPs. And that's kind of where you saw all these telehealth services like Rose, Hems, and Hers jump on this bandwagon to get you these things. But when it comes to compounding pharmacies, some of them are registered with the state and licensed by the state and some do not. So the quality you're getting can vary widely. And it's on the consumer to see which of these compounding pharmacies are at a very high standard and which are perhaps a little more dubious. But it can be very hard for the average person to release us because some of these telehealth providers, they're not actually pharmacies. They're just distribution networks for compounding pharmacies. So it can be very confusing. And then adding on top of that, the FDA said that these compounding pharmacies can't do carbon copies of the GLP drugs anymore because there's no longer a shortage. So some of them are now adding things that are like vitamin B12 to the formulation. And people don't necessarily know how that's going to react in their bodies. And so they may be getting different effects than they're expecting. And separate from compounding pharmacies, there are what's been referred to online as Chinese peptides or peptides that are coming from suppliers in China that are, quote unquote, research only. So there's a lot of confusion as to the sourcing of these more experimental peptides. Yeah, it's funny. I was actually in a coffee shop a couple of weeks ago and a couple of guys were working on a startup pitch very aggressively out loud that seemed to boil down to them being like, no one's thought of this. We're going to make IV therapy bags full of peptides and we'll source them for people. And people have a menu that will take all the guesswork out. We'll be able to tell them, oh, these are the effects you want. Here's your IV bag. And they were like literally asking ChatGPT how compounding pharmacies work. So that was horrifying to me. And I think we're going to see a lot of scrappy businesses like that. But you've also reported on some big names who are kind of peptide washing and throwing around terms that they don't understand. Is that right? Yeah. I recently wrote a story about I don know if Gwyneth Paltrow knows what a peptide truly is Like I know she heard of them and I know she into injectables and IV therapies Like she spoken about them widely She talked about taking glutathione, which is a peptide, but just the way that she has talked about them, I'm just like, are you aware that peptides and injections are not necessarily the same thing? I can't tell from some of the interviews she's done. Like she did one with Elle and the way that that article was written, it defined NAD plus as a peptide. NAD plus is not a peptide. NAD is nicotinamide adenine dinucleotide. You'll often see it marketed along with other peptides as NAD plus, but it is not a peptide. It is a coenzyme or a molecule that makes various enzymes more effective. It is associated with aging because it's in every cell in your body and your NAD levels as you get older naturally decline. And it's associated with some aging related conditions like saggy skin, metabolic dysfunction. And on TikTok, for example, you'll see a lot of people hawking NAD supplementation or NAD IV bags, NAD shots and pens. And so she has this moisturizer through her Goop brand called, I believe it's called Youth Boost NAD Plus Peptide Rich Cream. And I went through the ingredient list. And first of all, it doesn't have NAD Plus. It has something called NMN, which is like nicomatide mononucleotide, which is a precursor to NAD. And there's only one single peptide listed in the entire ingredient list. And it's at the very end of the ingredient list. And if you look at ingredient lists, generally they're listed by a concentration. So that means it's a trace amount, which does not feel like it's a peptide-rich cream in that respect. So it's a standard moisturizer with a sprinkling of high-tech sounding ingredients in there. So, you know, I was basically writing about the peptide washing of that and how a lot of wellness products out here will sell you something saying that it's hopping on a very buzzworthy, trendy thing. So, yeah. Well, there's also, you know, like those guys I overheard in the coffee shop, this sense that if you can just cobble together the right peptides, it can do literally anything for you. And obviously, that's almost certainly not true. But are there any potential risks in using any of these beyond the risk of getting something that's not a peptide at all from a dubious source? That's something that's being studied at the moment. You are seeing a lot of people online doing something called stacking these peptides. For example, one very popular one is called the Wolverine stack. And it's a combination of a peptide called BPC-157 and TB-500. and all of these experimental peptides, they really sound like Star Wars droid names. And basically what these peptides are purported to do is to help with tissue repair, wound healing, muscle recovery. So you see a lot of gym bros take it. And then on top of the Wolverine stack, if you add GHKCU, which is a copper peptide, they call it the glow stack, and that's supposed to do everything that the Wolverine stack does, but also add skincare benefits like improved collagen and elasticity and skin firming qualities if you add copper to it, but you maybe don't want to DIY this. You can have copper toxicity from this. There is something called the copper uglies where people don't dose correctly and it gives them the opposite effect on their skin where it creates adverse reactions in that sense. But because so many of these peptides have not been rigorously studied for human use, we actually don't know what some of the negative impacts could be. There are researchers who are really scared or they're concerned that it could actually cause cancer growth or encourage cancer growth because some of these are growth hormone analogs. And I believe one of them is like linked to pancreatic and other forms of cancer cell pathway growth. And even with the GLP drugs, we're still studying them right now. The vast majority of clinical research with these GLPs is for diabetics and obesity. There are a lot of studies going on right now about how they could impact things like polycystic ovary syndrome, fatty liver disease. There's a lot of promise and hope, but the fact is that we don't necessarily know how a lot of these drugs act in different conditions, which is why it can be hard to get them through traditional safer routes. And what you're seeing with, well, I'm just going to DIY it, I'm going to get it myself, is a real frustration with the healthcare system because people are saying, oh, wow, look at how efficacious these things are Look at how some people are saying it completely changed their lives and I can get it And the healthcare system is not something that I had a good experience with I might as well just take a risk and go to these more dubious sources because I'll do anything to have good health. They are reacting to kind of the brokenness and the flaws in the U.S. healthcare system and in terms of like access to affordable medication or a lot of people go to doctors and they feel like they're being churned through a factory. So there is kind of a practical reason why this is happening. There is a lot of misinformation happening online as well. And a really huge narrative I see from influencers is these pharmaceutical companies don't want you to have access to this because all they care about is their copyright and their profit. And There's enough truth in that that they then use it to discredit medical institutions. And this is kind of how you get the wellness to Maha pipeline happening. Yeah, well, and I'm glad you brought up Maha. This is a great segue to RFK Jr., who is very into peptides, I think, because it lines up with all of the issues, tension around the current health care paradigm that you outlined. So with this strong government support, what do you think that's going to mean for peptides? So in July, the FDA is going to convene to discuss whether 14 peptides that were previously not approved for compounding use will get moved to a list that allows them to be compounded. But basically, RFK Jr. has stated that he thinks it was illegal that the Biden administration took 19 of these peptides and said, hey, these are not safe for compounding use. We're going to move them to category two, which is like you can't use them in compounding unless the FDA gives express permission in a specific use case for the compounding. And moving them to category one would mean that compounding pharmacies can go like, hey, we're going to have a lot of access to these peptides. And he's made the argument that by doing so, it's a form of harm reduction. Because people are going to gray market sources, because people are buying these peptides from China and perhaps are not doing a lot of research or third-party testing to check the purity of the things that they're buying, if we bring it into a category one bulk substance, then we can kind of make sure that reputable compounding pharmacies are selling these peptides. And if this ends up happening in July, I think the market will explode in a way that I don't know that we're necessarily prepared for. There's a high demand for peptides. There is distrust with the medical institutions. And some former FDA officials have said that RFK has mischaracterized their work. RFK has some very specific opinions about what the FDA should be doing. he has said something along the lines of it was illegal for the FDA to move those 19 peptides to the you can't use this for compounding list because the FDA in his words is not meant to research efficacy it's only there for safety and if it doesn't kill you you should be able to inject it if you want so that's kind of the logic he put out there which is just fundamentally not what the FDA does. The FDA does study both efficacy and safety, and it advises based on those two factors. So there's a lot of rhetoric happening, a lot of dismantling of trust in established institutions that is very much wound up with this whole peptide craze. I just want to make it clear, peptides are not inherently evil. Injections are not inherently evil. There is a time and a place for this. Insulin is the very first peptide that we synthetically found and is a life-saving thing. GLPs have changed lives for many people. The way we are treating them in the mainstream biohacking culture, it needs more nuance. We're seeing like a lot of these tendrils of peptide biohacking culture just seep into various areas of health and wellness, and it keeps me up at night. That's all for today. We'll be back on Monday with our weekly science news roundup. Science Quickly is produced by me, Rachel Feltman, along with Fonda Mwangi, Sushmita Patek, and Jeff Dalvisio. This episode was edited by Alex Liguera. Shana Posis and Aaron Shattuck fact-check our show. Our theme music was composed by Dominic Smith. Subscribe to Scientific American for more up-to-date and in-depth science news. For Scientific American, this is Rachel Feltman. Have a great weekend. you
