Buying a car can feel like guesswork. Is it really the right price or should you wait? With car gurus you get unbiased deal ratings, price change history and trusted dealer reviews, so you can spot a great deal and buy with confidence. Go to cargurus.co.uk for complete vehicle details without any surprises. That's C-A-R-G-U-R-U-S.co.uk. Car gurus.co.uk. Car gurus. Search. Buy. Cell Sorted. The major inflammatory amplifying transcription factor, we call that nuclear factor Kappa Beta. When NFKB, when that gets activated, it's like this massive alarm in the body. Welcome back to the podcast. Today's episode is on the truth about cellular inflammation and chronic disease. I'm going to break down really the cell danger response and what's happening at the cellular level when we're dealing with inflammation and chronic disease. You guys are in for a treat, a lot of high-level science here, but I think you guys will understand this. In fact, you probably for the first time for many of you guys that you'll understand what's happening at the cellular level when it comes to inflammation. This is a great episode for you. If you're dealing with chronic inflammatory issues, be sure to check out our health coaching program. We work with people all over the world through video conference, phone conference. We look at labs. We look at functional questionnaires and really help guide you on the best clinical protocols for whatever it is you're dealing with or whatever health goals you have. You can email us at infoatdrjockers.com and we can get you in touch with our health coaches. You can learn more about our health coaching program. Again, we work with people all over the world with a wide variety of health issues. Email us infoatdrjockers.com, type in the subject box, health coaching, and we'll connect you with one of our amazing health coaches and naturopaths and really take great care of you wherever you're at and whatever you're dealing with. Be sure to do that. Of course, again, leave a five-star review on this podcast. You guys are in for a treat with this episode. God bless you. Thanks so much for being a part of our podcast community and let's go into the episode. I have great news. You can regrow your hair. You see, scientists in Switzerland have made a stark discovery. Hair loss doesn't have anything to do with age. In fact, it has to do with your hair follicles getting turned off and now they've found out how to turn them back on. You see, your hair cycles through three main phases, growth, transition, and shedding. And here's the problem. Some people's hair just doesn't grow back after shedding. The follicles get stuck before they can return to the growing phase. That's where anagane new comes in, a compound carefully extracted from pea sprouts by Swiss researchers. This compound is clinically proven to stimulate hair follicle cells and turn them back on, sending them immediately into the growing phase. To guarantee you experience these effects, PURALITY HEALTH has infused anagane new with their powerful MYCELL liposomal formula so that your body can fully absorb and use this compound. But don't just take my word for it. PURALITY HEALTH gives you six whole months to try their formula so that you can see this new growth for yourself. Plus, they're currently offering a special buy one, get one free deal backed by a 180-day money back guarantee. So six months to try it out risk-free to access this exclusive buy one, get one free deal and turn your hair follicles back on, simply visit renewyourhair.com forward slash drj. That's renewyourhair.com forward slash drj to start regrowing your hair today. In this video, I'm talking about the truth about inflammation, what's actually happening in our body when we have inflammation and how do we actually turn it off in our system. So inflammation really gets a bad rap in our society. In fact, some of the most commonly prescribed medications are anti-inflammatory medications or non-steroidal anti-inflammatory medications, a class we call NSAIDs. We also have steroids to help reduce inflammation. Of course, in natural health, we talk about anti-inflammatory nutrition plans and anti-inflammatory herbs and supplements. We know that inflammation though is actually a life-saving mechanism in our body. It's a physiological process that literally is designed to save our lives. You see, our ancestors, when they had some sort of trauma, like for example, they fell out of a tree and they would get physical trauma, or even if it was an emotional trauma, the body actually got ready to try to prevent any sort of infection from getting into the bloodstream and killing us. So for example, when they had some sort of tissue trauma, let's say they got hit by a spear or bitten by an animal or something along those lines, bacteria would get into the bloodstream and those bacteria were potentially pathogens. So they would travel up and the body said, okay, wow, we got to do something about this because if they got into the lungs and created pneumonia or they got into our brain and caused encephalitis or nervous system and created meningitis, that would kill us quickly. In fact, more people have been killed throughout the history of mankind from some sort of a systemic infection than from anything else. When people got killed in war, it was usually actually the infection they got from whatever the wound was that killed them. And so this is why our body responds to a high stress load, trauma, physical trauma, or any sort of high stress load as a potential risk factor for getting an infection that could kill us quickly. So back when we were more tribal, if you had a conflict with, let's say, a tribal leader or something along those lines, oftentimes it ended up in a fight and that could cause a tissue injury, which could cause an infection or you could get ostracized, which could lead to a whole lot of problems. And so the way that we deal with stress and all of these different factors is our body drives up inflammation in the body. So inflammation, again, designed to make sure we don't die quickly. However, we've got to get inflammation under control as quickly as possible and get back to a state of balance and homeostasis. And what happens in our society today is we're constantly overloading our system with biological stressors, like, for example, infections or nutrient deficiencies, bad sleep, bad circadian rhythm, psychological stressors like mental emotional stress, we've got chemical stressors coming from pesticides, herbicides, all different types of chemicals, and then physical stressors, right? We might have trauma or something along those lines. And all of those things bombard our system and create a high, what we call allostatic load, the overall load on our system that our body has to adapt to. And if it, if that load gets too strong and we can't adapt effectively, it's going to trigger an inflammatory cycle and ultimately it can be a self-perpetuating inflammatory cycle. See, when we have a tissue injury, right, we release something called damps and pamps. Damps are what we call damage associated molecular patterns. So from tissue damage, for example. So it's our own self-tissue and it sees molecular patterns involved with that. And then pamps are pathogen associated molecular patterns. And so both of those will now bind to what we call pattern recognition receptors. You may have heard of things like toll-like receptor, node-like receptor. These are becoming more and more talked about in the scientific literature. You also have one called C-type lectin-like receptor. And so those will all trigger the major inflammatory amplifying transcription factor. We call that nuclear factor cap-a-beta. When NFKB, when that gets activated, it's like this massive alarm in the body. Right? And so, you know, think about it like, for example, a city that's being overrun with criminals. And so if there's one criminal that's causing problems, right, one or two cops will go and, you know, take care of them and arrest them. But if you have a, if you have a riot going on, now that triggers an alarm in the city and now all the police officers come running out, right, to try to stop the riot. And so let's say those police officers hadn't slept well, they're a little irritable, and on top of that, they're blindfolded, right? Now they're going to run out and they feel, they feel threatened. And so they start shooting, right? Now they may shoot some of the bad guys, but they also may shoot good people and, you know, damage a lot of innocent bystanders as well as, you know, structures, innocent structures that weren't a part of it. And so this is kind of what happens in our immune system. For our immune system is not balanced and the NFKB pathway is elevated. Now we start creating kind of this widespread inflammatory cycle. We want a really balanced, calm immune system. We want an immune system that's really calm, doesn't overreact, right, doesn't underreact, but gives the appropriate response to whatever the, you know, the threat is. And so normally that's how a healthy, well-functioning person should be. And that, that immune response should be for as short amount of time as possible because it's very energy demanding for our system. And that's why when we get the flu or something like that, we get really tired because our body needs to divert as much energy as possible into healing and repairing and making sure that the virus or whatever the pathogen is, doesn't continue to replicate. So the NFKB pathway is a self-amplifying cycle. So it just continues to trigger inflammation, inflammation, inflammation throughout the whole body, right, until we turn it off. Okay. So we've got to be able to turn NFKB off. Now, what are the main things that drive NFKB? I talked about the damps and pamps, right, damage associated molecular patterns as well as a pathogen associated molecular patterns that would be coming from bacteria or parasites. For example, the outer cell wall of what we call gram negative bacteria released something called lipopolysaccharides or LPS. It's one of the major drivers of inflammation. And so we all have gram negative bacteria in our system. But if they are released, if they're getting into the bloodstream or if they, their cell components, their breakdown products are getting into the bloodstream at high levels, that's going to trigger the self-amplifying cycle of inflammation, this massive alarm that goes off in our body driving inflammation. Well, I just want to interrupt this podcast for a very important public service announcement. One of the most dangerous things you may be doing for your health is cooking a healthy meal at home. I know that sounds crazy, but here's what the science says. Most of us are unknowingly swallowing thousands of shreds of microplastic with every stir-fry egg scrambler veggie saute. Now, where's it coming from? Your nonstick pan. In fact, one 2024 study found that just a single scratch on a Teflon coated surface can release over 9,000 plastic particles into your food. And those plastic particles don't just pass through your body, they build up in your arteries, in your brain, and they disrupt your hormones along the way. One study found that people with plastic lodged in their arteries were four and a half times more likely to suffer a heart attack or a stroke. Another found plastic particles the size of a crayon tip inside actual brain tissue. And others now link microplastics to hormonal imbalances and fertility issues. So just like cigarette smoke in the 1950s or leaded gasoline in the 70s, microplastics are today's invisible toxin. They're creeping into our bodies daily while the science scrambles to catch up. And it's not just old pans. Even brand new nonstick cookware can start shredding particles from the very first use. That's why I switched to the P600 ceramic cookware. It's 100% free from Teflon, PFA's and plastic coatings. It's made with Swiss engineered ceramic and it's truly non-toxic. It cooks beautifully, cleans easily, and most importantly, it doesn't poison your food. If you're serious about reducing your toxic load, this is one upgrade I highly recommend. Right now the P600 cookware is 50% off. And for a limited time, you can take an extra 20% off with the code SAFE20 at checkout. Just head to chefsfoundry.com forward slash jokers to claim your discount now. But stock is limited and this bonus discount could end at any time. So use the code SAFE20, SAFE20 at chefsfoundry. All one word, C-H-E-F-S foundry.com forward slash jokers before this offer disappears. Your body will thank you, but so will your family. If you're into good nutrition, you've probably purchased a protein bar or energy bar before. And there are some really big problems with these bars. Number one, the bars that taste good are typically not good for you. In fact, many protein bars have as much sugar as a candy bar. They have junk ingredients like artificial flavors and sweeteners and really low quality toxic protein like soy protein. Some have barely any protein and they should really be called carb bars because they are just so full of sugar. And they also have lots of scary additives you don't want in your body. Honestly, you're probably better off eating a candy bar than most mainstream health bars. The second big problem is that the bars that are better for you typically taste terrible. You know what I'm talking about? They're chalky, chewy. Many of them have a really strong artificial sweetener flavor that you just can't get out of your mouth. Plus, you can't be sure that the ingredients are even high quality. And that's why I'm so happy to have Paleo Valley Superfood bars. Paleo Valley bars are full of powerful ingredients like collagen protein from 100% grass-fed beef. Now collagen protein, it's full of peptides and amino acids that support gut health, joint function and wrinkle free skin. Also, the superfood bars have real whole foods like kale, broccoli, blueberries and spirulina. So you get more than just protein. You get tons of nutrients and the bar could truly be a stand in for a meal. And they have delicious flavors like apple cinnamon, lemon meringue, they have red velvet and chocolate chip. These taste great. My kids love them. They're only organic ingredients, nothing artificial with no chemical sweeteners. Now you can go to paleovali.com forward slash jokers and save 15%. Check out the superfood bars and all the other great Paleo Valley bars. Again, just go to paleovali.com forward slash jokers. That link will save you 15% on anything that you buy. Be sure to check out their superfood bars. I love the lemon meringue and the red velvet. I think you'll like them as well. So check that out today. We also have high oxidative stress and that oxidative stress is taking place within the cell. So inside the cell, the actual mitochondria is dealing with and all the different proteins are dealing with oxidative stress. Now normally we have intracellular antioxidants, in particular three well-studied ones, catalase, superoxide, dismutase, and glutathione peroxidase. And so these all help to down-regulate intracellular stress, oxidative stress, or rusting from inside the cell. And so normally we should be dealing, we should have some oxidative stress, but we should be able to neutralize it and keep it under control when we can't because either we're not producing enough of these intracellular antioxidants or the cell is just bombarded with high amounts of oxidative stress, maybe from a virus, maybe because our cell is stuck in glycation. It's not able to burn fat. We know fat is a more cleaner energy source. We're able to produce a lot of cellular energy without a lot of oxidative stress, whereas glucose or sugar, we can produce quick energy, but we also produce a lot of oxidative stress. And so if we're metabolically inflexible, we can't burn fat well, we're going to produce more oxidative stress. If the cell structure is under a high oxidative load, then that's going to trigger an FKB. And then the other thing is on the outer cell wall of the cell, we have a lipid bilayer of all the cells, all the cell membranes. And we also produce something called prostaglandins from out here. And these are lipid molecules that act like hormones, and they are cell-to-cell communication. They help to drive different activity. And if we're eating a lot of bad fats, for example, a lot of omega-6 fats, things like seed oils, grain-fed animal products, as opposed to grass-fed, that's going to have a lot of high omega-6 fats in them. And if we're eating a diet that has a lot of these omega-6, we end up producing very pro-inflammatory prostaglandins, prostaglandin E2 in particular, which drives more inflammation, triggers the NFKB pathway. And so whereas if you were to eat a lot more omega-3s and create the proper ratio of omega-6 to omega-3, then we'll produce more of the prostaglandin E3, which keeps inflammation under control. So that's one element. So these are major precursors, driving NFKB. And ultimately, all these things lead to a cell danger response. Now, the cell danger response, we should have a complete healing cycle. If we don't, if we get stuck in one of the key areas of the cell danger response, that's going to, again, trigger this self-amplifying cycle of inflammation. So a lot of stuff right there, a lot of information. How do we address it? Well, we've got to support our body's natural ability to adapt, heal, and repair. How do we do that? Sleep. Sleep is really key. Really good quality sleep. Down regulates NFKB, right? Down regulates all the inflammatory cycles in our body and triggers hormones like human growth hormone, which signal healing, which really start to repair tissues, repair the overall structure of our body, whether it's our gut, whether it's our muscle tissue, things that have been damaged. HGH, human growth hormone, really helps trigger the repair process there. So that's key. We get a large amount of HGH while we're sleeping, particularly if our circadian rhythm is balanced and functioning well. Proper light exposure, sunlight, getting good sun exposure helps down regulate NFKB, helps, of course, increase vitamin D. Vitamin D is this really powerful, what we call prohormone. It shouldn't even be labeled a vitamin, but it has really powerful anti-inflammatory effects, or what we call immune modulating effects. So I say anti-inflammatory because if we have a high-firing inflammatory process, an immune modulator, immune balancer, will bring inflammation down. If we're not producing inflammation and we should be, it will bring it up in order to get rid of pathogens, in order to allow our body to be able to adapt and heal. So it's an immune modulator. So getting good sun exposure, things like red light or infrared therapy can be really helpful here. That helps down regulate NFKB, down regulate inflammation. So getting the proper light exposure, very important. Movement, just moving your body. Your muscles release something called myokines. Myokines have been shown to down regulate NFKB throughout the whole body. So going out and just taking a walk, super critical for down regulating this inflammatory cascade. If you're just laying around your sedentary, you're actually doing your body worse favor. Now there are times to be resting, right? That is very important. You don't want to over train or over move, but you definitely need some level of movement, some level of muscle contraction throughout the day to get inflammation under control. Nature, just getting out in nature. I recommend getting out, if you can, barefoot, grass, dirt, sand, being exposed to the ground, the natural healing electromagnetic frequencies from the ground, that basically like shower off our body's electromagnetic frequency, which reduces stress on our system. And that allows us to heal and adapt better. You can also go out in the woods. You can go for a hike out in the woods. And the trees are releasing a healthy electromagnetic frequency that's really helpful for your body. There's also essential oils, natural essential oils that come from plants. And when we're breathing them in because we're out in nature, that's going to be really helpful for our system. That's going to help down regulate inflammation. You know, obviously you can get essential oils and essential oils have been well documented to help bring down inflammation. And the reason why is because these are kind of natural sense that we would get in nature. And when we're out in the woods, when we're taking a hike on a mountain or whatever it is, we're being exposed to these things. And they have a calming effect on our system, really support the immune system, help modulate and balance the immune system. And so very key. Okay. And you can also have essential oils diffusing in your house. So you're breathing that in, right? Almost trying to mimic nature. Now it's not quite the same as getting time in nature. You're not getting the change in the electromagnetic frequency, but at least you're getting these essential oils into your system, which calm and balance your nervous system can help calm inflammation in general. So that's really key. Obviously we talked about the sun exposure you get when you're in nature, reducing your toxin exposure. So doing your best to replace whether it's, you know, hygiene products that maybe have a lot of chemicals in them, just reducing your overall exposure to chemicals. If you're in a moldy home, getting out of that home, whatever you can to reduce the overall exposure to toxic chemicals, that's going to help improve your body's ability to adapt and function better. And then increasing nutrients, right? And so, again, if you're deficient in nutrients, whether it's vitamin D, zinc, magnesium, amino acids, B vitamins, whatever it is, getting good quality nutrients in your body, maybe it's, it's antioxidants, right? In fact, you know, we talked about NFKB, some of the best things to downregulate NFKB are things like omega three fatty acids, vitamin D, turmeric or the active compound in turmeric curcumin, which has been well studied to help downregulate NFKB. And the higher the NFKB is firing, the larger the dosage you may need to bring that down. Resveratrol, another compound that's been well studied to bring down NFKB. Quercetin, another great compound for that. Anacetylcysteine, or anything that's going to help boost glutathione, another, another great thing to help bring down the NFKB. Even zinc, selenium, if you're deficient in those kind of compounds, they're going to help bring down NFKB. So getting the right nutrients on board as well, making sure that the food you're consuming is food that's going to help support your body, that your body responds well to, very important for bringing down inflammation in general. So ultimately, you know, to summarize that inflammation is a life-saving process, but when the overall allostatic load on our body gets too much and we're not able to adapt, repair and heal, we get stuck in what we call the cell danger response, which triggers this self-amplifying cycle of inflammation in our body. We've got to address it. It's not overly complicated. It's focusing on things basically that help to calm our nervous system and trigger compounds within our body, like human growth hormone, for example, and different anti-inflammatory pathways, different immune balancing pathways that bring inflammation down under control so we can then adapt, heal, and repair properly. Well, that's all for this show and I want to thank you again for spending your valuable time with me today. And if there was something you heard in this interview that you have questions on or you want to dive into deeper, then DrJockers.com is the best place to go. If you enjoyed this episode, please consider taking just a quick moment and giving us a great review. Your reviews help us influence more people and transform more lives. And if you took something valuable away from this episode, then please share it with someone in your life. You know it can help. We'll see you soon on our future podcast. Be blessed, everybody.
