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This Week in Startups

Podcasts · Technology

This Week in Startups

1,231 episodes · 20 with AI analysis

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world’s greatest founders, operators, investors, and innovators.

AI Intelligence · across all analyzed episodes

Analyzed Episodes

Jun 1, 2026

This Startup Fused Human Brain Cells with Silicon Chips | E2295

Biological ComputingNeuron-Silicon IntegrationAgricultural Drone Automation
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May 27, 2026

The Drone Company Quietly Taking Over Delivery

Drone delivery economics and profitabilityGPS jamming and alternative navigation systemsComputer vision for drone positioning
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May 29, 2026

How to Raise a Seed Round in 2026: Ask Jason | E2294

Seed round fundraising strategiesAI competition and differentiationHardware startup advantages
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May 9, 2026

5,000+ Tech Workers Laid Off This Week. It's Just The Beginning. | E2286

On-Premise AI Infrastructure for Regulated IndustriesProof-of-Human Verification and Biometric IdentityTech Layoffs and AI-Driven Workforce Optimization
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May 6, 2026

The end of Venture Capital? (VC Roundtable) | E2285

Venture Capital Concentration and Market StructureConsensus Capital vs. Traditional Venture CapitalAI Gross Margins and Token Cost Economics
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Apr 29, 2026

The $10M+ Bet on a Beanie That Reads Your Brain | Sabi & the Future of BCI | E2282

Non-invasive brain-computer interfaces (BCI)Deep learning for biosignal decodingThought-to-text translation technology
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Apr 25, 2026

The Defense Tech Startup YC Kicked Out of a Meeting is Now Arming America | E2280

Defense Tech Startups and Military Innovation3D-Printed Solid Rocket Motors and Propellant ManufacturingWearable AI and Embedded Computer Vision
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Apr 22, 2026

SpaceX and Cursor team up to topple Claude Code | E2279

SpaceX-Cursor Partnership and AI Coding Model CompetitionBitTensor Subnet Economics and Incentive DesignBitstarter Incubator Program for Decentralized ML Research
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Apr 3, 2026

AI Rebuilt Every YC W26 Startup. Should Founders Be Scared? | E2271

AI Agent Capabilities and LimitationsStartup Defensibility and Competitive MoatsAI-Generated Marketing and Regulatory Compliance
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Apr 2, 2026

How 3 CEOs Use AI to Run $10B in Companies | This Week in AI

Large Tabular Models (LTMs) for Enterprise AIStructured Data vs Unstructured Data in AIAI Data Center Infrastructure and Bottlenecks
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Apr 1, 2026

Venture Roundtable: SpaceX IPO, AI's PR Crisis, and the Defense Tech Bubble | E2270

SpaceX IPO timing and valuation expectationsAI public trust crisis and communication failuresWealth distribution mechanisms (equity participation vs. UBI)
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Mar 31, 2026

The 5-Step Framework for AI Agents That Improve While You Sleep | E2269

OpenClaw agent configuration and managementAI agent team coordination strategiesCron scheduling for autonomous AI operations
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Mar 27, 2026

The $60 billion resource hiding in space, and the start trying to mine it (feat. Matt Gialich, Astroforge) | E2268

Asteroid Mining EconomicsDecentralized AI TrainingOpen Source SaaS Alternatives
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Mar 26, 2026

This Bittensor Subnet Could Cut Drug Discovery Costs in HALF | E2267

Bittensor subnet economics and tokenomicsDrug discovery cost reduction through AIDecentralized pharmaceutical research
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Mar 25, 2026

$2.5B Chip Heist, The Future of American AI, and Purpose-Built Robots | This Week in AI Ep 6

Purpose-built robotics vs humanoid robotsGPU hardware competition and vendor lock-inChina chip smuggling and export controls
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Mar 20, 2026

The Drone Company Everyone Thought Was Illegal (Now Worth $4B+) | E2265

Drone delivery logisticsHardware startup challengesRegulatory navigation for new technologies
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Mar 18, 2026

How Robinhood became a $68B company w/ Vlad Tenev

Zero revenue business modelsMobile-first product designPayment for order flow controversy
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Mar 16, 2026

Are Brain-Computer Interfaces Actually Ready for Humans?

Brain-computer interfacesBlended wing body aircraftContinuous glucose monitoring
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Mar 14, 2026

One Genius Rule That Made This Coffee Brand Famous | EP 2262

Decentralized cloud storageBittensor subnet developmentMenu simplification strategy
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Mar 11, 2026

The Global Expansion of Self-Driving Vehicles

Autonomous vehicle safety standardsFleet management operationsRegulatory framework development
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