This Week in Startups

Podcasts · Technology

This Week in Startups

1,262 episodes · 20 with AI analysis

Jason Calacanis covers startups, tech, markets, media, and all the hottest topics in business and technology. He also interviews the world's greatest founders, operators, investors, and innovators.

AI Intelligence · across all analyzed episodes

Topics · top 10

AI-native fund administration and ERP for investment firmsLong-horizon AI agents for financial document processing and data migrationLegacy fund admin stack replacement (QuickBooks, Excel, Bill.com)AUM-based pricing model vs. traditional B2B SaaS subscriptionCPA role evolution in AI-augmented financial operationsBottom-up SaaS go-to-market strategy in enterprise softwareActive-user and usage-based pricing models in SaaSCOVID-19 impact on remote work adoption and enterprise software demandGoogle Panda algorithm update and platform risk for content businessesFigma's collaborative design platform and AI agent integration

Analyzed Episodes

Jul 6, 2026

$100T is managed by “human duct tape” | E2308

AI-native fund administration and ERP for investment firmsLong-horizon AI agents for financial document processing and data migrationLegacy fund admin stack replacement (QuickBooks, Excel, Bill.com)
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Jul 1, 2026

Why the VC Hype Cycle Always Gets It Wrong | VC Roundtable | E2307

Oversized Seed and Series A Round Valuations in AIOpen-Weight Model Adoption and Cost Reduction (GLM 5.2)Pre-AI Company Pivots and 'Burn the Boats' Strategies
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Jun 24, 2026

Why the Future of Video Games is Moving Back to the Dinner Table

Face-to-face gaming console hardware innovationCapacitive touch technology for physical game piece recognitionHardware startup prototyping and capital-efficient development
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Jun 27, 2026

Why F1 Teams are Replacing Wind Tunnels with Smart Tape | E2305

Real-world aerodynamic data collection via sensor tapeWind tunnel disruption in Formula 1 and motorsportOpenAI GPT-5.6 series government-delayed model release
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Jun 29, 2026

Chamath on why young people need more agency, risk, and adventure

AI-driven enterprise software development and Software Factory platformsAgentic workflow orchestration for business process automationEnterprise software unbundling and the $4 trillion maintenance market opportunity
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Jun 10, 2026

Why the most expensive Seed deals are the cheapest | E2299

AI Company IPOsSeed Round ValuationsAI Token Economics
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Jun 8, 2026

The AI Tutor That Makes Kids Actually Think | E2298

AI-powered tutoring systemsSocratic teaching methodologyEducational technology pricing strategies
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Jun 6, 2026

Anthropic wants to slow AI down and Bernie wants 50%: JCal Reacts | E2297

AI Development RegulationWealth Redistribution from AIUniversal Basic Income
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Jun 3, 2026

The Startup Turning Space Into a Logistics Network

Orbital logistics and satellite transportationSpace propulsion technologyConstruction automation and robotics
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Jun 1, 2026

This Startup Fused Human Brain Cells with Silicon Chips | E2295

Biological ComputingNeuron-Silicon IntegrationAgricultural Drone Automation
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May 27, 2026

The Drone Company Quietly Taking Over Delivery

Drone delivery economics and profitabilityGPS jamming and alternative navigation systemsComputer vision for drone positioning
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May 29, 2026

How to Raise a Seed Round in 2026: Ask Jason | E2294

Seed round fundraising strategiesAI competition and differentiationHardware startup advantages
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May 9, 2026

5,000+ Tech Workers Laid Off This Week. It's Just The Beginning. | E2286

On-Premise AI Infrastructure for Regulated IndustriesProof-of-Human Verification and Biometric IdentityTech Layoffs and AI-Driven Workforce Optimization
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May 6, 2026

The end of Venture Capital? (VC Roundtable) | E2285

Venture Capital Concentration and Market StructureConsensus Capital vs. Traditional Venture CapitalAI Gross Margins and Token Cost Economics
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Apr 29, 2026

The $10M+ Bet on a Beanie That Reads Your Brain | Sabi & the Future of BCI | E2282

Non-invasive brain-computer interfaces (BCI)Deep learning for biosignal decodingThought-to-text translation technology
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Apr 25, 2026

The Defense Tech Startup YC Kicked Out of a Meeting is Now Arming America | E2280

Defense Tech Startups and Military Innovation3D-Printed Solid Rocket Motors and Propellant ManufacturingWearable AI and Embedded Computer Vision
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Apr 22, 2026

SpaceX and Cursor team up to topple Claude Code | E2279

SpaceX-Cursor Partnership and AI Coding Model CompetitionBitTensor Subnet Economics and Incentive DesignBitstarter Incubator Program for Decentralized ML Research
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Apr 3, 2026

AI Rebuilt Every YC W26 Startup. Should Founders Be Scared? | E2271

AI Agent Capabilities and LimitationsStartup Defensibility and Competitive MoatsAI-Generated Marketing and Regulatory Compliance
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Apr 2, 2026

How 3 CEOs Use AI to Run $10B in Companies | This Week in AI

Large Tabular Models (LTMs) for Enterprise AIStructured Data vs Unstructured Data in AIAI Data Center Infrastructure and Bottlenecks
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Apr 1, 2026

Venture Roundtable: SpaceX IPO, AI's PR Crisis, and the Defense Tech Bubble | E2270

SpaceX IPO timing and valuation expectationsAI public trust crisis and communication failuresWealth distribution mechanisms (equity participation vs. UBI)
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