136. Dr. Goodenowe: Plasmalogens and the Hidden Science of Longevity

Welcome to Extend with me, Dr. Darshan Shah, a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your health span. Having become one of the youngest doctors in the country at the age of 21 and trained in board certified to the Mayo Clinic, I've accumulated three decades of practice as a board certified surgeon and longevity expert. Over that time, I've discovered that a mere 20% of health knowledge yields 80% of the results when it comes to your health span. We are living in a new era where we are creating a new healthcare system, no longer focused on disease management, but achieving optimal health and vitality. Join me as an interview, world-renowned experts, offering you a step-by-step guide to proactively avoid disease and most importantly, extend your health span. Today we're joined by Dr. Dan Goodenau. He's a neuroscientist, biochemist, synthetic organic chemist, and one of the most influential researchers in modern cellular health. In 1999, he invented a groundbreaking mass spectrometry technology that allows scientists to analyze human biochemistry in unprecedented detail. After studying tens of thousands of people, he discovered something revolutionary. Every major disease has an early biochemical signature, a pro-drome that appears years or even decades before symptoms. His work led to patents across more than 20 diseases and to one of the most important innovations in preventative medicine, plus malignant precursor technology designed to restore critical molecules that decline early in aging, cognitive decline, and chronic disease. Dr. Dan Goodenau is a founder of pro-drome science and the creator of the pro-drome scan, a test that measures key biomarkers of vulnerability long before disease develops. His mission is simple but profound. Don't wait for disease. Measure health, maintain it, and restore the body's biochemical resilience before things break. In this episode, we get into plasmalogins. Early brain deterioration, the future of diagnostics and how MRI technologies evolving, the three M's of longevity, and why purpose and mood are biochemical necessities for long term vitality. Here's Dr. Dan Goodenau. Dr. Goodenau is such an incredible honor to have you here. As I was just telling you, a very strong, strong, to have you here, you're one of the scientists that all of us longevity physicians or just physicians in general really look up to as really creating an entire new thought process around cellular health that we've never had before. Thank you for joining. Dr. Strong, so happy to be here. I'd love to start the conversation with, there's an entire body of cellular health that most physicians don't have access to. That is the integrity and the function of the cellular membrane, the membrane around the cell. We call this membrane a lipid bilayer or a bi-lippid layer. We don't really think about it a lot because we don't think there's any way to really affect it or there's nothing we can really do about it, right? Except we try to get drugs smashed through this lipid bilayer into the cell. That's the only reason we really study it. You've dedicated your entire career to molecules that function in this bilayer and their precursors and et cetera, and really have seen massive improvement in many health conditions. Just to frame the conversation, that's what we're going to be diving into today. Awesome. I love it. Cellular bowel chemistry is my briar branch. I could tell. I could tell. I would love to hear just from a big picture how you discovered molecules that could function in this way and your back story in coming into this field. But what's so exciting about doing all this work right now is because I'm a PhD research scientist in neurochemistry and synthetic organic chemist. I'm not a medical doctor, right? So I come through my educational program looking at these basic science avenues and we do research, animal studies, cell culture studies, and we study science from that type of hypothesis driven perspective, right? And the medical doctors in the world, they have a different type of training. They deal with, you know, how do I use and apply tools and technologies, whether it's a drug, whether it's a therapy, how do I diagnose a given condition, and you're working so intimately with the human condition, right? And then that goes on and they become basically artists working with their patients. And so what's exciting about us working together is that I've had to come from the scientific background and then most scientists don't ever see a human being, right? They're in laboratories or we deal with large amounts of information, we publish papers, we go to hold it. The conferences that scientists go to, medical doctors don't go to. Exactly. And so there's two different worlds and they're very rarely combined. Right. And what's so exciting about this advanced medical area is all these doctors are really getting excited about cellular chemistry and understanding there's got to be more. And many of them have had personal experiences where they've used their training and say, you know what, something's missing. Right. I've kind of exhausted the medical tools in my disposal, but I'm not giving up. So they start digging deeper and deeper things. And that's kind of where we meet in the middle, exactly, which is, which is really quite exciting. And then the other aspect of my background is in infrastructure, right? Logistics, clinical trials, laboratories, manufacturing, you know, which is, you know, when you're going to this new advanced world of cellular biochemistry, you have all these products, but they're being used by specialty doctors and little pieces here, little pieces there. And trying to organize and consolidate them. And so this has been just a wonderful experience for me. And I'm getting more and more addicted to working with all these doctors with every waking month. It's like you're like vertically integrating everything in the process, right? Like you've gone from the cellular biochemistry to the manufacturing and the, the scientific tools that you use as well, all the way up to the patient care piece of it and bringing it the full journey, which is so exciting. Or we're all kind of kids in a new toy store. Basically the medical doctor is coming and he's, oh, I had no idea. There's some cool toys in here I can play with. Right. And then my, on the other side saying, this is great. We actually have case studies. We can do case series. We can take, here's complex patients that we can work together with. We can do advanced blood testing. We do advanced MRI. We can intervene with these biochemical intermediates plus maligents. And so it's been really kind of my background is like a doctor's background, but in a different area. I start from scratch from my first, you know, addiction to chemistry, understanding how the biochemistry of the world works. And so my background is in that biochemical perspective. And then back in the 90s, we were doing all these genomics, right? We're sequencing the human genome for the first time. And we're trying to understand gene expression analysis and scientists were developing these, what's called non-targeted methods. Okay. Science typically has always been hypothesis driven. Right. And then we have these ideas, right? Vitamin C, I'm going to test vitamin C on something, right? Sure. But when we started sequencing the full genome of the human body, we didn't know anything about any of these genes, right? So it became hypothesis creating. So we actually run the experiments first and then look at the data afterwards and say, hey, what was going on? And that changed, I don't think people truly realize how that period of time in the 90s upended 5,000 years of philosophy. For the first time in a life we could generate these large data sets and then after the fact say what's in here? And me as a biochemist, there was no tool to measure biochemistry comprehensively. And so my first real invention was this ion cyclotron technology that measured thousands and thousands of molecules simultaneously without knowing what the art first. Yes. And so then you apply this type of technology to different disease states. So we look at people with Parkinson's or Alzheimer's or colon cancer and pancreatic cancer and we say okay, if you have a group of people that are cancer-free for example and you have a group of people with cancer there's obviously difference like there should be biochemical difference because our human body is a biochemical system. Right. In this advanced technology was able to identify the biochemical differences between people with different diseases. And in Alzheimer's and cognition one of the molecules that showed up was these plasma and I had no idea what they were. And I'm a neurochemist, right? I've studied my whole training is on the biochemistry of the brain. Right. And so I'm finding these molecules really low in all these people with cognitive impairment or dementia. And the more severe the depletion was, the more severe the dementia was. And we did multiple, multiple trials in this. And so the way the mass spectrometer works it measures acrid mass and you get them elected a formula. Okay. And these molecules with this NPO7 structure was coming out of line. And it's gone. Which was very strange for me because it's normally eight auctions. So it was really geeking out on you right now. But so I'm looking at these molecules and I'm going what are these things? And seriously I back in, I was googling and trying to figure out these structures and I found out their called plasma logins. And so I was the person who invented or discovered plasma logins for the first time. Like those were discovered back in the 20s. Wow. And we've known the critical component of plasma logins because we have certain rare diseases that are mutations that are known that if people have mutations in certain genes that make plasma logins, you get children that have called one of the diseases called rhizomelic, congeas plasia, puncata. Okay. And others like lucidistrophysin things. Uh huh. And these children are born with dwarfism. They're born with intellectual disabilities. They ultimately die within a short period of life. So we know plasma logins are critical. Right. And these are molecules that are part of this lipid bilayer that you're talking about. And so that's kind of where that all came from. That's where it all came from. And then you kind of, it's like pulling a thread of yarn and you kind of get, you get something and you get kind of curious about it and then you kind of keep on pulling the string. And then you know, 20 years later you're still doing this. Yeah, you're still pulling this trick. So just to kind of like paint the picture there. I mean, this is pretty incredible that there was a scientific revolution that happened with the sequencing of the genome because at first time we could just create a massive data set. And then be like, what does this data even mean? And so that kind of changed your thought process around just, just how to approach science. So you invented a machine that could then look at thousands of serum biomarkers. I assume in the serum, right? And you have now you have thousands of markers and you don't know what they mean. So your idea then was to look at someone that had Alzheimer's and then one that didn't and what was the difference in their in that data, right? And so then you can extrapolate like this person with Alzheimer's has these molecules or a deficiency of these molecules that this person doesn't have. Correct. And then you went down into that rabbit hole into what are those molecules? And you found out that they were actually discovered before. There are plus malogens. Right. And now you have a group of molecules that you know have some association with Alzheimer's disease. But at this point, you probably don't know whether they, whether Alzheimer's or even like ALS or Parkinson's, if the problem was the deficiency of these or maybe this just an association, right? Correct. Is there a causation or an association between this? And so how do you kind of figure that question out? How do you, yeah. So those are the, that falls at different line of clinical trials. I mean, for the plasma agents, the reason why you're sure to be causal is that we look at the longitudinal nature of individuals. So we can cross-sectional analysis of individuals at different stages of disease. Got it. And then we did a large study with the Russian University in Chicago where they have a very large longitudinal trials been going on for 20 some years. And we could, and the blood samples are stored. Oh. And so then we could take blood samples at, before people had dementia. Yes. And we could predict who would get dementia in the future based upon blood levels. And so those people that had, that were not cognitively impaired. So they had normal cognition. But they had low blood plasma agents. Those individuals became demented in the near future. And so we should show that this was linked to that. Was one of the big aspects of it. Another area that we really did a lot of work with is in cancer. Okay. And so the real genesis of pro-dromes, because when I first dealt with technology, I thought, well, this is like great. It's a diagnostic. We can diagnose disease. Yes. Like a blood test, right? And we can do early detection of disease. Yeah. And cancer is a good example. We, we'd expect this tumor is doing something to the body, right? Uh-huh. And so cancers have these other deficiencies that are very commonly observed. These GTAs and fossil collings. Okay. And we did this at the time. This was back in the early 2000s. We expected that the tumor must be consuming these molecules, creating this deficiency. Got it. So we did this study in Osaka, Japan, where we looked at people with colon cancer before and after surgery. So we did blood testing. They went for surgery. They were called cancer-free. And we were expecting these biomarkers come back to normal. Sure. Because they're not being consumed anymore. Right. It didn't happen. Biomarkers were exactly the same. Oh. No change in the biomarkers at all. And we said, wow, this was not what we expected. So we re-did the entire project over again with a different university this time in Chiba University, outside of Tokyo, and got exactly the same results. And that's when their light bulb really came on, in that we're actually measuring people that will get future disease. We're not measuring molecules after this. And so this is a concept of pro-drums. And so we're measuring ball tires that become flat. Okay, we're not actually measuring a puncture wound. Okay, we're actually measuring ball tires and saying, hey, you're likely to get a flat tire in the future. Yes. You continue on. And this is where the plasma agents had very similar situation. Because they're also low in cancer patients, not just dementia patients. And they don't get, we did a big study with breast cancer. This is with another project in Japan with Kyoto University. High diagnostic accuracy, 93% diagnostic accuracy. And we looked at women, we did two separate studies out of Kyoto on breast cancer, looking at before and after proper surgery in chemo. And again, not only did the plasma agents not come back to normal, the chemotherapy actually reduced the plasma agents even further, which leads this whole concept of recurrence of disease. Right. Right. So a lot of times when we think we're treating a disease, like a cancer where we remove the tumor, but we all know that people who have a history of cancer have a higher probability of recurrence. Sure. than someone who never had cancer in the first place. Right. And so we could actually explain that. We could actually explain why previous cancer made you more susceptible to future cancer. Okay. Okay. And so this is, so we understand these pro-drums now. So clearly, there is this concept of deviation from health versus disease. So it's kind of the concept, because we think of disease like a pathology, right? We get infection or get something. Something happened. Happened to me, right? And that's a normal process. But in reality, we lose health. Right. And this is what gets exciting about the whole longevity, immortality, okay? Concept of quantitative immortality, because you don't actually get disease. You lose health. You lose health, right? And you don't actually die. You lose life. Mm-hmm. And as a scientist, go back to physics, right? You know, and I'm a Canadian boy, so we talk about cold, right? Because it was always cold. And technically, it's not cold. It's just less. Black of heat, right? And so, which is hard, it's a hard argument to make sometimes when it's 40 degrees below. But the point is, is that, technically speaking, there's no such thing as cold. Right. There's either heat or lack of heat. And so technically, there's no such thing as death, or it's either life or lack of life. You don't actually get death. Death, right? Exactly. You don't actually get disease other than the bacterial infection for some. Yes. And so, this whole concept now says, that also changes your mindset, because it's nice. Yeah. If the loss of health is what gives me disease, or the loss of life is what gives me less longevity or death, then what is health? Yeah. What is life biochemically? And can we then measure that? Because we can predict mortality. Sure. And this is the issue with the Rush University Project, because we're doing it with prediction of dementia. Mm-hmm. But of course, this is elderly population. Mm-hmm. And they eventually die. And so, we also completely serendipitously, we said, oh, wow, you know what? Let's look at all cause mortality. Okay. And turned out that the plasma agents predicted all cause mortality more than dementia. It was a 30-year difference in lifespan based upon someone's plasma levels. Wow. It was a crazy, crazy number. That is crazy. But this changes the whole world, because now it's opened up a whole new idea that we can say, you know what? Let's stop chasing disease. It's create health. It's create health. Yeah. And so, but then we have to measure just the deviation from health. Right. Now, it's a concept of the dipstick in your car, right? I don't wait for engine failure. If the levels will be a certain level, because the lower level, I top it off. Right? And so that's the concept of, here's healthy oil levels. Yes. And we know that. And I always make this joke, you know, if you're old enough, you had old cars that used to burn oil. Yeah. And so I used to have a car like, same thing. Every time I got gas, I had to check your oil. Right? Right. And so just to make sure. Yeah. But now my new car, I heard they ever checked your oil. They checked your oil every, you know, two, three thousand miles when it's the oil change, right? So this is the whole concept of preventative maintenance. Right. Right. And the concept of now, if we can understand our health and we can understand the time frame for certain deviations, we can start reducing some of our anxiety. We don't have to be so obsessive on everything. Yeah. Because that's one of the challenges of health, which no one really knows what's going to happen to them next, right? We're always a little bit worried. Right. You know, we've walked down the street and going to get hit by lightning or we're going to get some disease. Yeah. And you have no knowledge. And so that's kind of where we're working together more on. Now, it's understanding what health is. Yes. So that we can measure the deviation from health. Right. And then once we measure deviation from health, we say, well, let's restore it. Restore it, right? And then we want to have fun. We want to push it even further. Exactly. And then we can push it even further. So invest the concept also of being resilience, right? Because when you push it further, you can be resilient to anything that occurs. Right. But just to take it back a little bit, so plus malignant molecules, what you found was a deficiency of these molecules led to not just Alzheimer's, but all cause mortality, meaning cardiovascular disease, cancers, everything. And so in a deficiency also led to recurrence of tumors. So the situation is one if you know your plasma logins are low, you need to get them back up to a normal level. Correct. And that is one aspect of creating health. And when you have health, that is the absence of disease. And so I always say, you know, it's plasional or walls here, is that true health is not simply the absence of disease. It's the abundance of having vitality, right? Exactly. And so I think plasma logins, one of those molecules, is not often talked about as being a component to that vitality. And once you dig into these plasma molecules, you really get almost angry, because why have you not been told about the trial? We're talking molecules that 20, 30% of the entire brain, children development, the myelination of the brain. Sure. Okay, children are born slightly plasma-aging development. The plasma-aging precursors and breast milk that link to increased white matter development. Uh-huh. But we're talking about molecules that make up, you know, a huge percentage of the myelons sheet that the protective coating in your axons, in your synapses, the gray matter, that 85% of the, of these ethanol amines are plasma logins. 50% of the total lipid composition of your heart, are plasma logins. Hi, that was in your kidneys. They are, they are critical drivers of your reverse cholesterol transport system. Uh-huh. So we're talking about HDL levels, HDL control. Okay. People think what Alzheimer's disease in the apoe for genotype. Yeah. And plasma logins are related to the amyloid processing system in the brain. Okay. And so we're not dealing with some trace level molecules. Right. Like not even like, if you talk about a lot of these, like a serotonin neurotransmitter, or like we're talking a core structural molecule. It's on the same plane ground as cholesterol, as you know, and phosphocoline. It's at that level of bulk. Yeah. And there's pounds and pounds of pounds that are body. Right. And it's interesting because the body is so dependent on it. Right. It basically says, I'm not going to trust you to get it from your diet. I'm going to make it on myself. Clestrol is another one. Right. Your body, we get very little cholesterol from our diet. Yeah. Our body needs cholesterol so badly that it will make all of its cholesterol from scratch. Reveal. Plast Belgians the same thing. Sure. And for most of your life, you're fine. Yep. And it peaks in our blood levels and our brain in our 40s and 50s. Okay. And then it starts going down dramatically. Oh, so it actually peaks in the 40s and 50s. Yeah. Interesting. Okay. And assuming you're healthy, it would obviously be people with low levels are really wrong. Right. That have other consequences. But your body makes it from precursors so it doesn't mean specific nutrients to make these plasmallogens, right? Yeah. So actually, the normal biosynthesis makes it from simple acetylchoy. It makes it from the simplest of simplest molecules. Absolutely. Very, very basic. But you can't, the challenge that came up in the early 2000s is when I discovered these plasmallogens, then we had to do these testing. So you talk with causation, right? Yes. And so in order for us to test the causation, we need to be able to manipulate the plasmallogen levels. So how do I increase plasmallogen levels? How do I decrease plasmallogen levels in animal studies? So the first thing was how do we restore plasmallogens? Well, wasn't as easy as you think. Because we're dealing in 2006 is when I first invented the first plasmallogen precursor that could actually restore plasmallogen levels. No, you think, well, that's 80 years after plasmallogen were discussed. And with no one of these children are dying from plasmallogen deficiencies. So the inability to restore plasmallogens was a big, big problem that no one had solved. So it was all that. I'm so sorry to interrupt you, but these children are dying from plasmallogen deficiencies because they have a genetic condition that doesn't allow them to synthesize plasmallogen. That's why we know it's a critical molecule. Because if you have a genetic deficiency, it's like a Mendelian study, right? Like you know that these kids are going to die, so it's a critical molecule. And so then that from that we can infer that our body makes this for a critical reason, because without it, you will die, right? And so, okay, so then... And there have been other good scientists have looked at this in early childhood development in other areas. So plasmallogen had been studied, but nobody could actually manipulate plasmallogen levels appropriately. And so in 2006, I invented these plasmallogen precursors. Okay. That could, they would come into the body's biochemical system just before you make the plasmallogen. So we could actually make whatever plasmallogen we want using these precursors. So it's bypassing part of the synthesis system. Presumably, if you're a child that's deficient in one path, one part of the pathway, and you take a precursor, you bypass that system, and now you've bypassed that deficiency, right? And for the rest of us, who just as a graduate, graduate get older, that one system is called your proxysome. Oh, okay. So it's one of your organelles in your cells that make your plasmallogen is called proxysomes. And this is in every cell in the body. Every cell in the body, yeah. And typically that decreases in function as we get older. And so we stop making enough plasmallogens. So we can replace them. So we all, as we get older, we become more and more like RSCDP, basically, aging. So but back to your original question, was okay, what's the association versus causation? Yes, please. So now we could get these plasmallogen precursors. We could now do animal studies, we could do cell culture studies, and we're able to show very clearly that they regulate HDL, the cholesterol transport. And then we can do these trials for really severe neurodegeneration studies. Okay. So for example, Parkinson's, there's a nanomodil for Parkinson's called MPTP, very reproducibly destroys dopamine neurons in the brain. And it's actually interesting, was discovered by these kids in California, in the, I think it was late 80s, they were trying to make designer heroin. And exactly. So there was a boat, I can't remember how many, there's three or four of them that showed up in the hospital in Riverside with full blown Parkinson's. Look, like in the 20s, like full blown Parkinson's. And we're going, what's going on with these people? They were totally frozen. And so they did the research and they found out that there was a toxic byproduct of their heroin manufacturing in their house. Okay. That was called MPTP. So ever since then, we could, in animals, create Parkinson's on demand by giving this toxin. Oh, I see, got it. So now we had this plasma-malogen precursors. Yes. We say, okay, let's, let's give animals a toxin. Oh. But let's give them plasma-malogens. If we give them the plasma-malogens, the toxin doesn't cause any Parkinson's. We can completely prevent Parkinson's. And so we can restore the membrane of structure that this toxin was destroying. That's incredible. And then, and we know that plasma-malogens associated with Parkinson's is a risk factor. And we, for white matter disease, there's another toxin that we use is called Cuperzone. It's a molecule that keylates copper, but it reproducesly creates multiple sclerosis. Deplase myonation. If you give animals plasma-malogen precursors, the Cuperzone causes no demolination. That keyl will prevent that it'll maintain myelination in the presence of these toxic mediators. Wow. So clearly tells us that deficient plasma-malogens, or insufficient plasma-malogens, lead, you know, are a critical component of these diseases. So if you have high levels, or if you supplement them, in which is why now we have all these clinical case studies with our patients with multiple sclerosis, you may have seen one of mine with Lisa Grillo, who was blind for 30 years. You can see for the first time. Amazing. And we can restore that with plasma-malogen precursors. So that's kind of this causation. So now we know, unambiguously, that they're not, you know, bystanders of an accident. Like they're not some, some, you know, serendipitous, you know. Right. Right. Is that like just a biomarker of the disease? It's actually a part of the disease process. So exactly. With, um, I mean, that's incredible. There were Parkinson's. There's this, drug those are discovered by heroin makers in California that can create Parkinson's and animals. And if you give a plasma-malogen, you can actually prevent the Parkinson's from happening with this drug. And the same holds true with MS, you said, with the other drug that can create MS and animals as well. We can bypass the drug. And so this could be a potential molecule for people that are suffering from Parkinson's or MS to utilize in their overall treatment algorithm. Exactly. And this is this is a whole restorative health model. Right. How we can actually, and the resilience of the human body, the adaptability of the human body and the human brain is quite remarkable. People, and you know, I spent a lot of time on the neurological side of these sure equation because it seems to be a reponderance. But the myocarditis, like a lot of the myocarditis that children were getting with COVID, a lot of our pediatricians, the use of plasma, which is very effectively at restoring heart structure and function in these children. But for brain, we use advanced MRIs. So we can actually now study the regrowth of the brain. Right. So for Lisa Grillo, for MS or other patients with Parkinson's, we can now study how the brain responds with aging and how we can reverse the aging of the brain and restore the health and function of the brain. Because, you know, one of the things we use with advanced MRI technology is we can measure cortical thickness with accuracy. Yes. And so we measure like 600 regions of the brain and it's certainly to get thin. And I'm a good case study of that myself because I thought I'd be, you know, a control animal, if you will. It's like, I'm high functioning, I'm fine. Yeah. So I got my my advanced brain scan done like three years ago now, almost four years ago. And unfortunately, I had some areas. I had a concussion when I was eight years old. Oh, it is. So it was actually had post-concussive industry from eight years to my, and certain areas of my occipital cortex, which related to my vision, were quite thin. And I've been able to restore those completely. So I've been able to reverse the aging of my brain back into its forties now. Wow. Over the course of these several years, and we can now track that. So with the MRI scan. With the MRI scan. And what's important about us is that the brain is kind of like a muscle. Like if you wake, you work out with weights, you're going to build muscle. If your brain can restore its function, it actually restores the thickness of those that, that layer. And so that's kind of what we're doing with all of our clients. Now we can actually get their baseline brain scans, put them on an advanced protocol, plus malignant is a critical component of it. Obviously, while we have their attention, we give them a few more things. And then we can monitor their brain restoration now in a quantitative way. God, this is where this whole quantitative immortality comes in, where we can actually say, hmm, can we actually get to a point where we can have a high degree of predictability that you're not going to die? Oh, who? Yeah. Which is kind of another weird flip from the script, because we're normally trying to predict when you die, or trying to predict when you'll get a disease. But if we reverse the statistics and we say, okay, what's the probability, so really immortality is the probability that you're going to die in the next two years to be zero. Sure. And then two years from now, we do that. And if it's still zero, and I just want every year to be zero. Exactly. I'm for sure. I mean, so the way these molecules work is sounds like there's one group of them that can help you remyelinate or help you cover the axons of your neurons. So for people that don't know, your neurons or your brain cells, axons are the big long connections between neurons, and they need to have a covering around them. Correct. Just like an electrical wire, right? If an electric wire doesn't have a covering, it'll short circuit and won't work correctly. And so these molecules cover the neurons so they can connect better. And this actually shows up in the MRI as kind of thickening of your brain tissue, right? When you say cortical thinning, it's the brain tissue's thinning. And then if you can thicken them up again, that's a sign of a young brain, of a healthy brain, right? And so you see that in the special MRI that you do. Yeah. And can anyone get this MRI? Like if I'm 53 now, I want to get an MRI to see what my brain ages based on the thickness of my brain. Can I do that? Absolutely. Yeah. Give us a call. We'll schedule a visit. I love it. And we'll go through it. And we look at the cortical thickness. We look at blood flow. We look at some advanced called neurite imaging that looks at the fiber densities. And so for people that don't study the brain all day long, people think of the brain as like a computer. And it's so shocking to me when we're looking at health and vitality. We want to look at our body fat, with muscle density and all the things. We kind of forget what's going on behind our skull. We can't really see it. Well, it's kind of a black box because there's no good way to really evaluate it until now, until MRI technology. Exactly. And I think for people to know too, you can't just get an MRI anywhere. MRI is a piece of hardware. It's the software that really is, I mean, you need a good piece of hardware, but then you need some really cool software to take advantage of the data you're getting from the MRI. Well, and that's the real frustrating part for medical doctors. Yes. Because you're only, you know, you send someone in for an MRI. It's like whatever the MRI tech has, right? It's a T1 or, you know, and what I found so frustrating is when I come into this space, I come in as a researcher. And I research all the literature papers. And so people have been doing in the MRI for years, right? But no doctor has access to this now. No. So it's not like, and this is a whole frustrating thing about some of the biochemistry that I teach people. It's not like I invented all this technology. Like a lot of the stuff that has been really massively intelligent people doing amazing work. But we don't have the implementation. We don't want to access it too with. Right? Like we use the I and Cyclotrons in our lab for measuring thousands of molecules. And we're the only place in the world that you can get a commercially available blood test for plasma-aging levels and seeing a mile in and a whole bunch of other things that are going to work. But it's not like I invented those molecules. There's papers for the last 20 years in specialty labs looking at this gun. And same thing with MRI. And so what we've really done is saying, how do we commercialize this? How do we create tools and education? Sure. So any doctor can get, like so we use this neurite orientation and dispersion density index called MODI. Okay. And it gives you white matter, microstructure analysis. Okay. And I didn't invent the technology. We tweak it a little bit. But there's no MRI facility that can do it. When we first ran it, it took us seven days. So it was five minutes in the scanner. And it was seven days of computer processing time. Wow. Okay. And so then we took the seven days. So which is why it's only done some academic center, right? And then it got down to 48 hours. And now we've got it down to it's a reason that we've put super computer behinding. And so, but so now people can go and get this advanced brain scan and it measures the white matter microstructure. Okay. And what does that tell you? It shows, so it's, so we talked about this. So the brain, again, is people think of it as a computer, but it's not. It's like a wiring diagram. Right. It's areas of gray matter connected by these wires, right? White matter. And as we had older, the wiring kind of, the coding kind of gets dissipated or like old wires in your wall if you would. And so this measures the structure of that versus just the volume. So you actually measure how the wires are working inside there. Oh, okay. And that's actually quite responsive to treatment. So when we restore that, and it's also the association with age is very strong. Oh, I see. So there's certain things that are more accurate determiners of the function of the brain. And those are the things that are responsive to the adaptability. So we've been able to restore that, which is exciting. So the last thing in the world you want to have is a blood test or some test as it says, it sucks to be you. Yeah, exactly. You know what I mean? You're going to die. Great. So this was cool about biochemistry. And this MRI neurology is that these are all intervenable programs. Absolutely. You actually measure this stuff not just to be morbid, but you actually measure it, say, okay, I can work on that. I can actually, okay, if I do these things, and then I can come back and I can test it again, and I can build a trajectory back, and I can build a program that I can reproducibly rinse and repeat, if you will. And cool. What's really frustrating for me as a physician is, you know, when I was taught about Alzheimer's disease, for example, in medical school, I was taught you wait for symptoms. The ones, the symptoms get really bad if you confirm Alzheimer's by getting a PET scan. And the PET scan lights up with amyloid. And by then, we all know it's just way too late to do anything significant, right? You're just making a diagnosis to basically tell someone to suck to be you, right? And what's frustrating for me is that there's this incredible technology out there, like the advanced MRI, where you take so much data and you crunch it using a supercomputer, finally, go that from seven days to one day, and you get a score for how well your neurons are connected. And then once you have that score, you can do something about it through various interventions, including plasma logins, to see the score improve, right? And you can track this longitudinally over time, the five minute MRI scan. That's, is that what you're saying? Well, there's a little longer than that. It's about 45 minutes. 45 minutes, okay. Could we do about eight or nine different things? Got it, got it. But is that kind of what we're saying here? Yes, exactly. That we can actually test, score, the functionality of your brain. So we're not just talking disease here, we're talking, like you're a highly functioning individual. And you found out that you had remnants of CTE. Oh, yeah. And you were able to improve that. And now you're more high functioning now. Very much so. Multi-tasking is so much better. Amazing. I visioned. So for example, my vision is back to when I was 17. Okay, so I have, I don't have headaches anymore. And so I just got my prescription. My nearsightedness is changed by a whole score. It was like, you used to be minus 1.75 and now it's 0.75. Like seriously, quantitative improvement in vision. That's incredible. And so yes, it's highly, you feel it. Yeah, regular life. Same thing with muscle mass. Like we work on, we now have tools that we can very clearly build muscle in an individual at 70, at the same rate as we can build at 30. And I'm physically stronger than I was in my 20s and 30s when I work on one. What are the tools for building muscle mass that you're working on? So we create, so one of the things that people deal with when they're, you go through these cycles of fasting in fat states, every single day of your life. And your body consumes energy from your fat cells. But it also takes energy from your muscle cells. And so there's specific biochemical systems that we can restore that prevent muscle wasting. And this actually came in our work with ALS a lot, in Parkinson's. And people that we were restoring their logical function, but we're still having a hard time getting, they're maintaining their weight and building your muscle structure. And so we've developed biochemical pathways that can restore muscle and build muscle mass at a much higher rate, which is kind of cool. Using plasma logins? Plasma logins are critical component of it. But these are your loose-seeing amino acids, certain amino acids that your muscles deplete overnight time. Right, right. And so we make a kind of a, we call it a muscle water that people take at night. And what's in it? Loosing, I know it's critical for you. Oh, it's a lot of much of a loose-seeing aligning. It's got myonositol. Oh, nice. ketone esters, triptophan, tri-, you know, it's a bunch of stuff in there. Oh, and the name of this product is called? Well, it's called, we call it muscle water. It's my two-o. It's my two-o. It's my two-o. My two-o, okay. I'm trying to. Well, it's not really commercially available. It is, it's part of our program. But it's so it's convincing to give me some. Yes, absolutely. It's quite addictive. Actually, my own person, because I always test everything on myself. I didn't change anything in my daily routine. Started using this. And over, I think, it was four to six weeks. Again, eight pounds of muscle, using the in-body and lost five pounds of fat. It was a crazy thing. It was like, oh, this is weird. And so clearly, there's something there. Many people get benefits from it. Incredible. But the point is, the body is resilient, in principle, and it's adaptable. And it's adaptable. And if we can restore the adaptability of the human body, and then put that body in an environment, a stimulating environment, whether it's a mentally stimulating environment or a physically stimulating environment, then we can, it can grow younger. So it's not about reversing your age. It's about getting older, but as you get older, you get better. Because you want to retain everything that you've learned, and you want to maintain your function. Sure. And so we talk about, often we use numbers. People like to lock with their age, but it's really a function. The heart's supposed to function, brain's a function. Kidney's a function, right? And if we can measure those functionalities carefully, then if you maintain function indefinitely, that is the longevity model. Yeah. I mean, right now we equate chronological age to a corresponding loss of function. And that's what you're saying. We need to break that model. Because you can age chronologically, but you can actually maintain function and reverse poor function as well, in your brain, in your muscles as well. Exactly. Function is the only thing that matters. Yes, absolutely. You can have a car, 1920's car, and if it's running, you don't need to, the real goal is to forget your age. Yes, forget the memory. How old are you? I don't remember. It doesn't matter. It doesn't matter. It's, can I do the things I need to do? To me, there's a three M's of a life worth living. It's mental acuity. You wanna think, right? You know, you'd be able to interact with your world, mobility, you need to meal the meal. And you're moved. You have to want to get up in the morning, get to a purpose. You have to, and so if you can maintain a good mood and purpose in life, and I tell people, you never retire, right? Retirement is basically putting a time stamp on your death. You're basically, okay, I'm going to just coast to death from here. So you should be, when you're 85, you should be thinking about your next career. Right. You could think, okay, what's my next now? What am I doing next, right? Right, and that's the mindset, because... The three M's is a beautiful way to simplify it down. You know, my mental acuity, my mood, my mobility, if I can have those three things, I'm okay. You're gonna be fine. I'm gonna be fine. And, you know, just focus on those things. But one of the biggest things we deal with, Dr. Yurth is really good at this one. Actually, you've interviewed her, is on purposefulness. It's this understanding purpose. Okay. And that's the other part of chronological age, because we forget, and people think, oh, stress is so bad, but stress is critical. We think, okay, I get, you know, you're going through high school, it's stressful, right? You're dating, you're trying to find, you know, what's gonna make you attractive to whatever partner you want. And then you get a job, because you know, you can have a relationship, and so it's stressful to get a job, and then you have kids, and then there's the kids have those relationships with them. So you have these milestones that you work towards. And those milestones create purpose. The reason for you to get up in the morning, reason for you to work hard, strive hard, right? And then people say, okay, now I'm 50 or 60, I can quit. I'm done with purposefulness. Well, then you've lost your purpose. Absolutely. And it's really hard, because people stop, it's not easy, because our average life kind of creates purpose for us. Like we kind of have to have a purpose. Exactly. And then later on in life, you kind of have to make your purpose up. Like if you don't have one, make one up. Right. And that's the biggest challenge as we get older. You know, your purpose in life just can't, you know, unless you want to be a professional golfer, but you can't be just, you know, you have to find something to keep you going. Right. And challenge yourself as you go forward on it. And those are the things that, you know, we do all these epidemiological trials where, you know, social connectivity and people getting out. And they think, well, you know, if you're gonna go out for coffee and bridge with your friends, well, you gotta get dressed. Then you can have a decent meal and you can have a conversation. And so all those things that surround those kind of interactions are health promoting. Absolutely. And that's kind of what, so we kind of work on the biochemistry side. Yeah. Measurement side on the MRI. Yes. And then on a community level, like, you know, getting bald, enjoy your life. Exactly. Get engaged with people. Right. And then, you know, because it's, you know, we still are social animals. We have to have a, it's such a huge part of longevity, right? And because even if you're biochemically very sound, and you are, you're taking care of your bio markers, what have you, all of that. If you lose that sense of purpose and community, you will still decline, right? Because then you're gonna get in a situation where you have loneliness and you're not learning anything. And there's, and you've lost your purpose. And all that adds up to a loss of the will to live, which then degrades your biology too, right? So it's definitely bidirectional. Yeah, it's circular. It's circular, yes. For dementia patients, for example, we start losing function. And then people don't want to, like, they're hearing, they're not following conversations. Sure. And they become more withdrawn. And so when we, what we find when we're working with people with dementia, and we bring people into our center in Canada, for example, and we start restoring their cognitive skills, they want to engage more. Absolutely. And then that becomes self-propeptuating. And one of the things that deals with restoring health, you know, plasma, what, probably the most rewarding thing about plasma, if I have to say one thing at all, it's with children with autism. There's nothing more exciting, because these children are kind of locked up. They're inside themselves, right? And we do a lot of work with children with great diseases. But these children, when they start interacting with their parents, and they start receiving things, and their sense of humor starts coming out. And they no longer become isolated, because the world becomes fun for them. And we can learn something from that, because part of interacting, like you and I interacting, is like, it's kind of fun. Like, what are you gonna ask me next? Right, right, right, right. Right? And so even if you're a kid and you're teasing your sisters, okay, if I say this, will she, how do I interact with something, right? And so all this playfulness that we do in this world has to do with our learning capability. And so building on these biochemical systems, they really do play a critical role. Absolutely. And we're just doing a big launch in children with autism. We do free programs with children and so on and so forth. But it's kind of, you can learn from different spectrums, right? You can look at these children, and you say, well, some are things happen with old people, or people with diseases, they get withdrawn. Right. And their health, their lack of health, with the lack of vitality, withdraws them from society. And so like you said, it's bidirectional. It's a circular, you know, and I'm always fairly agnostic. It's like, you know, I don't really care what it takes to get people healthy. If it works, keep going. If it works, keep going. I mean, to your point, you know, loss of hearing is highly correlated to dementia. And it's because of, I do think it's because you have less input. And so less input, both from learning, from being able to enjoy talking to other individuals and just being in social situations, and at least a further and faster de-regulation of your brain, right? Exactly. And then you don't move around as much, because you have nowhere to go. So then you become a mobile and sedentary, more. Yeah. Which is very circular, right? Exactly. Now. This episode was also brought to you by Vita Boom. Vita Boom is a revolutionary company that sends you a custom supplement protocol based on your needs using blood-based biomarkers. You can either send them your latest blood test or they will send you a fingerstick test for blood analysis. Vita Boom then curates and ships you an extremely convenient monthly box of daily supplement packs that have your custom protocol in them. What's great is that they also provide all the best brands, like Timeline, Trunyogen, and many others, for your custom daily backs. I love mine, especially for travel, since I don't have to bring 10 bottles of supplements with me and just open up a daily pack for every day that I'm taking my vitamins and supplements. Go to Vita Boom.com and check it out. I wanted to make sure I asked you about before I forgot Glea, right? So we didn't cover that yet. And I think it's this incredibly important piece of the story that I don't want my audience to miss out on. What are the micro Glea and how are plasmalleges important when you talk about these structures in your brain? Yeah, so yeah, so I only talked about lots of things. So from the practical perspective, so there's two things. So there's two different types of plasmalleges and precursors, first of all. You talk about, earlier on, you talked about the Omega 9s for the myelination and the white matter. And these are kind of protective. The calming, the reducing inflammation, people with ADHD, they basically say it's like reading glasses on my brain. And read sentences again, they can feel good. And then the neuro is more of the volume. It pumps you up. Like you get better physical activity, better cognition. It's kind of a stimulating plasmalleges. Is that Omega? Yes, you make a three. Omega three, right? With the DHA and it. Got it. And so micro Glea, which is so we call it the Proto-Glea because it works on white matter. But yeah, but and all the good ender sites are other types of Glea cells. Got it. But micro Glea, people when people mostly talk about micro Glea, they're talking about inflammation of the brain. Oh, okay. And that is cumcel. Versus every single neurological disease. Whenever the brain is sick, it's going to be inflamed. And wherever it's inflamed, you're going to have activated micro Glea. Right. Because that's the brain's healing mechanism. Basically, it's trying to solve a problem. Right. And but this activated micro Glea is quite damaging to the brain. Chronic neural inflammation of the brain, which is what causes, which is an autism, which is multiple sclerosis. Parkinson's dementia doesn't matter. And so one of the challenges now is the brain is kind of like a castle with a motor around it. It really has to fix itself from the inside. And this concussions are a good example. Okay. You get a concussion, the brain gets inflamed, and the blood supply is trying to help. But there's a limit to what the blood supply can actually deliver to the brain. I see. And how much the brain will let go of it. And so you get this chronic inflammation of the brain long term. And it consumes plasma allegins, it consumes other molecules, and it depletes the body. And so a lot of work has been done trying to reduce the inflammation of the brain as inflammation suppressants. Okay. And we've kind of looked at the micro Glea separately. It's we have to ask the question, what is stimulating these micro Glea? Like, why are they becoming activated? And they normally become activated because of these membranes you were talking about, get oxidized, just like rusty metal or peeling paint on the walls. Like it's oxidized. And the micro Glea kind of get attracted to those things. And we find that when we provide the plasma allegem precursors, it dramatically reduces the inflammation because we fix these cells from the inside out. And the inflammation goes down. And so that's kind of a key component. Mitochondral health, mitochondrial support, plasma allegins. And then we can now measure with this advanced MRI, the inflammation of the brain, which we're going to measure that too. Yes. So this node technology, that's on you about, it measures three types of water in the brain. Okay. A little geeky here on you. So water is inside the copper wire. Okay. These one type is called NERI water. Okay. And then there's cell water, there's in cell bodies. And then there's free water. And so the NERI water is your axon density, which is what you want. Interesting. Cell water is inflammation water. Okay. So when you have, especially white matter, you'll see, when we do our brain analysis, you'll see people with inflamed brain have a whole bunch of this cell bodies, which is micro Glea. Yep. And we now measure those going down. And so for example, my brain had these high levels of inflamed space and that inflammation went way down once we've been able to restore the inflammation of the brain. And then once the inflammation of the brain goes down, the brain can start healing itself. Got it. Got it. It's like having the flu. Yeah. Right? When you get the flu, you're tired because your body's fighting an infection. And it only has so much energy to go around. And so anyone has done this before and you get a flu. So I'm going to work myself through it and say, I'm going to go work out. Well, you just made your flu worse. Right. You can't power your way through a flu typically. Yeah. So give yourself some time to heal. Right. By the way, you're going to make it worse. Right. And that's kind of what goes on with the brain. That's exactly what goes on with the brain. And so this pro-dome Glea, it's called can help with that process as well. It helps the inflammation. It's really focused on the all the good insights in the white matter. Because that's really where the inflammation of the brain is. The inflammation is really a white matter. In the white matter. I see. This MRI sounds incredible. I can't wait to have one done. So I'm going to hit you up for that for a shot. Because I love to see kind of my notis score and the amount of inflammation that's there. And I think that with, I think a lot of my patients, for example, they come in and we can test biomarkers for a lot of different things now. Blood tests are becoming better and better and more and more ubiquitous. The brain still remains a black box, unfortunately, because there are not a lot of biomarkers of brain health that we have. And so recently now we are doing some more biomarkers. I just p-towed to 17 and you know, as amyloid ratios and G-fap. But these are all, I think, also disease markers that come kind of late in the stage. There's no real great biomarkers for the amount of brain health you have, right? And so it sounds like this advanced MRI could really be helped with that. And there is good, like those markers are great because they measure G-fap and your filament light change or axonal damage. So those are good markers to measure. They are kind of downstream, but still they're useful. And we can talk more about the, you know, metal transfer system and the brain and so on and so forth. But there are very clear biochemical markers of brain health. Okay. So the plasma level in the brain, we published this years ago, we get critical thinning based upon plasma deficiencies in the blood. And so there are HDL levels are important for brain health. Keeping triglyceride levels low are important for brain health. Fostial colon levels in the blood are critical for brain health. And so there are certain molecules that are definitely important to measure in the blood that are related to the fatty composition of the brain. Because your brain is basically a bunch of, it's quite fatty. And also peripheral markers of mitochondrial function are good markers of brain inflammation. And so there are more advanced blood testing. So you can do blood tests for a phosphatolcoline levels. Oh yeah. And do you do that in your laboratory? So can you tell me the name of the biomarker test that you do in your laboratory? So it's called bioscan. Bioscan. So we measure choline plasma allegins, ethanol plasma allegins, phospholcoline. And we measure the speciation stuff. And we measure to make a 9s and make a 3 plasma. And the choline pool and phospholcoline pool. We measure sphingle myelons and ceramides, which is an indicator of cellular breakdown. Really powerful is the liso-phosphatolcolines for cardiovascular health. So it's actually a very powerful measurement of the turnover. Break down a certain phosphatolipid. So we can measure these things. And so the biochemical health that we look at, core function, we look at mitochondrial function, peroxysoma function, your methyl transfer system, people may look at home of cysteine levels. It's important to look at your creatin levels in context. And so your phospholcoline levels to your ethanol mean levels. So the biochemical health can really powerfully tell you, like non-alcoholic fatty liver disease issues. You can look at inflammatory oxidative stress markers like we measure malindaldehyde and sucrose in the smute days and a few things. And we organize that into such a fashion that we get a clear understanding of an individual's health state. And we have a clear action. So you can take a look at, the bioskin, you know, measures a lot of things. But in the end, it identifies core components. And sometimes it's simple things that people, you know, sometimes we forget about the old biomarkers, which are really, really important. Right. Keeping your triglyceride levels under 100. You know, I can spend hours talking about cholesterol. Sure. And our obsession with low cholesterol, which is not good for people. Right. You know, and these couple of things. It's all so that it's kind of an inescapable blood test. Got it. And so it's not about, you know, we kind of repurpose the diagnostic test. Criatin is a good one. People measure creatinine because they're one of the, for kidney failure. Kidnail, right? But actually low creatinine is a much, much more dangerous situation. Really? It's a low creatinine. It means you have muscle wasting. That's true. So you get elderly. So it's a measure of muscle mass. And so people, you know, don't take enough creatine or phosphocolling in their diet. And so we can measure these things and change them. So that's what the bioskin does. It looks at these complex lipids, which is you, you know, and then we add other core biochemical systems on top of that. Bioskin. And this is something that you have to give a full blood sample for. It's a fingerstick. A fuller bottom. A fuller bottom. And we bio bank everyone's blood samples forever. Oh, amazing. Okay. So how can someone get a bioskin? You can give us a call. Okay. Or you can, our doctor network, we have about 3,000 doctors in our network. Got it. Get access. So there's elite practitioners that have access to this. Yeah. The full blown bioskin is there's a training program for our doctors to go through. But yeah, so the bioskin. So on your website, we can find a doctor that can do a bioskin. Yeah. And then they can submit a blood sample to your lab and you'll give all these results. And then that will tell us kind of our disease, disease risk and state of health actually for liver, cardiovascular, brain, et cetera. Exactly. And you get a pathway. You know, a lot of people in medicine, they use blood tests as, you take a blood test and based upon the blood test, I treat to the blood test. Yeah. And we kind of do it the other way around. Okay. We say we want to actually, we're going to restore biochemical function. And we use the blood test as a gold star. You're doing good job. So, you know, if we're doing these things, we should see your home assisting levels normalize to see these things going. And so, so sometimes, sometimes people, you're going to want the symptomatic feeling that you're getting better. But you also want to be able to measure quantitatively. Sure. Okay. The work that you're putting into it, the person's going to follow a protocol, do the things. And then you say, okay, I told you this is what's going to happen. This is what happened. Okay. You're on the right track. And then once you get yourself to a biochemically healthy state, then you say, okay, stick to, you got a program that works, stick to your program. Yeah. Okay. And it's long term, longevity, right? And so, it's not, and people say, people often question me at all the time, well, how long do I got to take these supplements? I go, well, how long do you drink water? How long do you drink? How long do you want to be healthy? Right. So, it's kind of maintaining this healthy state. So, yeah. So, the Dr. Gino Propetual Health Group, that is where we have the MRIs, we have bioscan, large protocols for, do a lot of hand holding with navigation teams and so on and so forth. And then ProDrome is where we have our doctor networks. And you can buy supplements at alacard at proDome.com. You can buy a hack yourself, you know, get education, there's that, you know, videos and so and so forth. So, it depends on the person's need. You know, some people need a lot of help. Yeah. And the people who need a lot of help, they're there to give them a lot of help. Those who want to do with themselves, they can do it themselves. And then, of course, we have these amazing network of doctors that have their own specialties. Sure. Okay. They'll have peptides and exosomes and stem cells and they'll do other things for people. And so, we kind of want to make sure that the clients have access to the technology that they feel best suits their needs and in the doctors, in our network, have the tools. And so, we plug our tools into their system and, you know, there's more than one way to get help. Incredible. Right. Exactly. And so, we're here working as a community. Yes. We plug in these advanced, you know, so for us, you know, these plasma algeons, supplements, advanced blood testing, advanced MRI. And then, you kind of plug in other modalities. Modalities. Modalities. As, you know, as appropriate for your patient or client. Awesome. As that may be. Yeah. And that's going back to what I said at the beginning, you've totally vertically integrated the solution here too. To testing the supplements and the molecules. But also, you said you had inpatient centers as well. Yeah. If you really need to go for a higher level of care. So, you have an entire solution for people that are struggling. And also, people can DIY it if they want to optimize as well. Yeah. So, my goal as an industrialist, and as a clinical trials expert and all that kind of stuff, is to kind of create this consolidated centralization system. Right. So, all of our doctors, 3000, and then we get blood samples, their samples are still in the freezer. So, when we get a new tool, we can go back to an old blood sample and rerun it. Wow. Okay. So, we said, why throw your blood samples away? Right. This bio-baked blood sample. Yeah. And then, let's also look at building structure. So, we can, we can solidate the blood sampling. Like, so, we can do other blood tests for people as well. And then, the, you know, tracking of individuals' health, and, you know, like these MRI tools, those aren't available, so we're going to standardize it, make it available. And then, what's important is that we, everything we make available to doctors, we use ourselves. Yes. Like, it's not like, oh, here's a cool idea. Let's just market this thing. No, we only, we only do the things that we ourselves run in our own centers and clinics. And so, then, our clinical trial infrastructure. So we'll be starting to running our temeculate program. We'll be having between one and two thousand patients in our trials at one point in time. So we can really properly validate this at full scale. And so, all of our doctors get advantages of that. So they can be part of that. They, their, their patients can be part of trials if they want to be, like, just on the side, like, just, like, you may as well look over the shoulders. Okay. Okay. We'll do that. Okay. So, we can run informal trials in their centers and, and track it available. So my job is just make things available, try to simplify the process and enable us to kind of, you know, continue to develop, because as we, the more doctors I train with, the stories that come in and the different, different situations, we're just getting better and better at it and trying to consolidate that information. So, especially the new doctors, right? We're getting about 100 new doctors a month coming into your system, right? And so, they're brand new. Like, just like this conversation, they don't know what plasma is, they don't know what blood testing are. And so they want protocols, they want examples, key studies, and they say, okay, I got a patient like this, you know, is there, who else has, is there a, is there a similar patient story that I can work from? Because they're, they're people are hungry. Yeah. These, these tools now, they've, they've got their formal training as a medical doctor or a river system they're in. And they know their world, okay, and they're getting certain levels of success doing what they're doing, okay? And then, but it's overwhelming. It's a lot of technology, a lot of things. So they need, and so our job is to kind of, you know, get a step by step process and build a community people that can help each other through this. Yeah, I think also that, you know, going through standard medical school and training, whether it be neurology or, you know, gastronology, liver disease, whatever have you, the number of tools you have worked for a lot of things, but you're always hitting a wall. And so to have additional tools that you've provided is incredible for treating patients. But also, there's a whole new world of optimizing your health so that we don't get disease in the first place. And we just create the situation like you were saying in the beginning of this podcast, where potentially you just live in a state of health indefinitely, right? And so just to know that this is a big piece of that, you know, we have hormones, we have peptides, we have stem cells, we have a lot of things, but plus maligms is another big piece of that puzzle. And just to know that information is incredibly empowering, I think, and also adds that whole puzzle that people are trying to put together right now. So, yeah, it's crazy because like, there's a lot of things that we intellectually know, like, you know, you take an anesthetal cysteine because you know it restores your glutathione levels. But you don't feel it, right? You take these plus maligms, you take the glee and you go to bed at night and you sleep through the night. You just fall through your bed, right? Or you start taking the neuro and you feel sharper, right? Your physical response time on your muscles are better. Your, you know, bright lights get brighter. Like, so it's not, there's, you know, as an academic and kind of a little bit of a geek myself, like I can still intellectually say, oh, yes, I need my B vitamins. Like, five minutes important, riboflavin. But you don't feel it, right? And so, plus maligms are one of those molecules that you actually feel. It's a very interesting, which is nice because then people start, oh, that works. Okay, now I'm going to listen a little more to, well, you fix a few more things, right? Exactly. And see, because you want to get that first little, it's like when you work out the gym, if you go start working out and you work out for three months and you see nothing happen on your body, like, you're not going to keep working out. Like, you got to get to that first level level. So, oh, I'm seeing some muscle growth. Right. I think I'm going to go back to the gym again. I know you need to win. You need to know the show. And I can't just be a theoretical win, right? They have to kind of feel a win, right? Right. And then once you have that, then you kind of have them. And then you can, and then, you know, you can kind of continue to feel the help process. Well, this is, this is so educational for me. Thank you so much. And I'm sure the listeners learned so much from this episode of the podcast with you. And, you know, there's a lot more to learn. So how can people find more information from you? So, Dr. Goodnow.com is where there's a bunch of educational processes there. You know, talk about programs. And there's the, from there, you'll see perpetual health group or pro-dram.com is where a doctor network is or self-preservable. There's information about the plasma allotions on any of those aspects of it. And then I do, you know, if you have a specific disease like multiple sclerosis or Parkinson's, I do detailed lectures of dealing with biochemical basis of each of those diseases. And so you get an understanding, I kind of teach people about their diseases in a way that is not normally presented. And we'll talk about the underlying biochemistry and pathophysiology and where these things come from. And look at this, this, how do you restore health from these circumstances? So, so get Dr. Goodnow.com is placed ago and then and pro-dram.com would be the two places to start. Well, thank you so much for this. You're welcome. You're welcome. And I can't wait to learn more from you. Thank you so much for being here. Thank you, Dr. Shaw. Dr. Goodnow is such an incredible scientist and wealth of information. Here in my top five takeaways from that incredible episode with Dr. Goodnow. Number one, you don't just get a disease, you lose health. Every condition begins with measurable biochemical changes long before symptoms develop. Disease is the late stage of long detectable decline with specific biomarkers. Number two, plus malogens are core molecules that protect the brain heart and immunity. They peak in midlife and they decline. Low plus malogens predict dementia, cancer vulnerability and all cause mortality. And precursors may restore levels and even prevent disease onset. Number three, the brain can be repaired and tracked. New MRI software can quantify brain tissue thickness and function, allowing doctors to monitor cognitive risk duration using plus malogen therapy along with many other interventions. Number four, longevity depends on the three M's, mental, mood and mobility. Mental chemistry matters, but without cognitive stimulation, emotional purpose and physical movement decline accelerates regardless of your molecular health. And finally, number five, chronic brain inflammation is a silent driver of aging. Microglial activation, low omega three to omega nine plus malogens and loss of sensory input, like hearing loss, for example, contributes to deterioration of the brain. But these markers should be measured so we can improve them. If you found this episode helpful, please forward along to a friend or family member that needs to learn more about their brain and how to keep it healthy. Thanks for joining again for the extent podcast. Thank you so much for listening to the podcast today. Please remember to subscribe if you liked this episode and give us a good review and share a link with your friends. It really helps to support all of our efforts. I also want to remind you that the information shared on this podcast is for educational purposes only. It is not intended to replace professional medical advice, diagnosis or treatment. Please consult with your healthcare provider or physician before making any decisions or taking any action based on what you hear today, especially if you have any underlying health conditions or on any medications. Your doctor knows your personal health situation the best and is always important to seek their guidance.