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Extend Podcast with Darshan Shah, MD

Podcasts · Health & Fitness

Extend Podcast with Darshan Shah, MD

170 episodes · 20 with AI analysis

Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results. That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview world-renowned medical practitioners, doctors, experts, and thought leaders, offering you a step-by-step guide and actionable advice to proactively avoid disease and optimize your health. Plus, I share weekly solo episodes giving you quick, digestible protocols for successfully extending your healthspan.

AI Intelligence · across all analyzed episodes

Topics · top 10

Estrobolome and estrogen metabolismGut microbiome changes during perimenopause and menopauseAdverse childhood events and trauma's impact on hormonal healthVagus nerve function and parasympathetic nervous system regulationHeart rate variability as biomarker for autonomic nervous system balanceBioidentical hormone replacement therapy protocols and timingDUTCH hormone metabolite testingFiber intake and microbiome diversitySmall intestinal permeability and autoimmune disease riskCumulative toxin exposure and detoxification pathways

Analyzed Episodes

May 19, 2026

165. Cynthia Thurlow: The Menopause Gut - Why Healing Your Hormones Starts With Healing Your Gut

Estrobolome and estrogen metabolismGut microbiome changes during perimenopause and menopauseAdverse childhood events and trauma's impact on hormonal health
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May 21, 2026

166. Carolina Reis de Oliveira: The Missing Link Between Skin and Longevity

Cellular senescence and senolytic peptidesLab-grown human skin models and tissue engineeringAI-designed peptides and machine learning in drug discovery
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Apr 21, 2026

157. Dr. Tania Elliott: Allergies, Immune Health, and Hidden Toxins in Your Home

Microbiome disruption and gut health as root cause of chronic inflammationHygiene hypothesis and early childhood immune system trainingHidden chemical exposures: BPA, Teflon, PFAS, synthetic fragrances in consumer products
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Apr 23, 2026

158. Dr. Kavin Mistry: Primal Health Design, Biological Aging, and Reconnecting with Human Biology

Tech Neck and Forward Head PostureSpinal Degeneration and Anatomical AgingMicrobiome Diversity and Prebiotic Foods
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Apr 28, 2026

159: Dr. Anurag Singh: Urolithin A, Mitophagy, and Mitochondrial Health

Urolithin A and mitophagy activationMitochondrial biogenesis and fission-fusion dynamicsGut microbiome polyphenol metabolism and postbiotics
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Apr 30, 2026

160. Dr. Kara Fitzgerald on Biological Age, Epigenetic Clocks, and the Future of Aging Reversal

Epigenetic clocks and biological age measurementPolyphenol compounds and gene expressionYamanaka factors and cellular reprogramming
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May 5, 2026

161. McCall McPherson: Why Your Thyroid Is Being Undertested And Undertreated

TSH limitations and thyroid hormone testing protocolsFree T3 as primary biomarker for thyroid function assessmentReverse T3 and T4-to-T3 conversion pathways
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May 7, 2026

162. Dr. Meredith Broderick: What An Undiagnosed Sleep Disorder Is Quietly Doing To Your Brain And Body

Sleep Apnea Diagnosis and ScreeningChronic Insomnia and Conditioned ArousalCognitive Behavioral Therapy for Insomnia (CBTI)
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May 12, 2026

163. Steve Chua: How Your Identity Is Either Healing Or Destroying Your Health

Identity and self-perception as health determinantsExecutive burnout and prevention strategiesMindset narratives and limiting beliefs
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May 14, 2026

164. SXSW Panel: How To Actually Take Control Of Your Health In 2026 and Beyond

Wearable technology and continuous health monitoringFunctional medicine and advanced lab testingSupplement industry verification and quality assurance
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Apr 2, 2026

152. Nick Norwitz: Cholesterol Myths, Insulin Resistance, and the Real Drivers of Heart Disease

LDL cholesterol vs. ApoB as cardiovascular risk markersStatin efficacy, side effects, and pleiotropyInsulin resistance as primary cardiovascular disease driver
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Dec 11, 2025

120. Jess Kane: Your Cells Are Leaking, Here's How to Fix Them

Phosphatidylcholine (PC) supplementation protocols and dosingCell membrane structure and phospholipid compositionToxic exposure mechanisms: microplastics, heavy metals, mold, Lyme disease
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Dec 16, 2025

121. How to Protect Your Brain at Every Age

Type 3 Diabetes and Brain Insulin ResistanceGlymphatic System and Sleep-Based Brain DetoxificationBlood-Based Biomarkers for Alzheimer's Detection (Amyloid, Tau, P-tau 217)
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Mar 24, 2026

149. Kim Rogers: Parasites, Hidden Infections, and the Cleanse Protocol for Gut Health, Energy, and Recovery

Parasitic infections and worm species in humansBiofilm formation and parasite detection methodsHerbal antiparasitic protocols and phased cleansing
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Mar 26, 2026

150. Dr. Terry Grossman: Plasma Exchange, Detoxification, and the Future of Longevity Medicine

Therapeutic Plasma Exchange (TPE) for detoxification and longevityHeavy metal and microplastic toxin testing and removalHormone optimization and bioidentical hormone replacement therapy
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Dec 18, 2025

122. Dr. Mayim Bialik on Stress, Mental Health, and Human Connection

Stress and nervous system regulation (sympathetic vs parasympathetic balance)Gut-brain-immune axis and microbiome healthChildhood trauma and intergenerational trauma
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Dec 23, 2025

123. Best of Metabolic Health: Why Metabolic Health Changes Everything

Metabolic Health Biomarkers and Early DetectionInsulin Resistance and Fasting Insulin TestingContinuous Glucose Monitoring Technology
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Dec 25, 2025

124. Best of Strength Training: Why Strength Determines How You Age

Muscle mass and metabolic healthFast-twitch vs. slow-twitch muscle fiber trainingStrength training protocols for men and women
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Dec 30, 2025

125. Best of Mental Health: The Foundation of Brain and Whole Body Health

Metabolic Psychiatry and Brain Energy ProductionNervous System Regulation and Parasympathetic ActivationNeuroplasticity and Visualization Training
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Mar 19, 2026

148. Fitz Koehler: The Four Pillars of Fitness and the Exact Formula for Strength, Fat Loss, and Longevity

Four Pillars of Fitness FrameworkStrength Training for WomenWeight Loss Formula and Caloric Budgeting
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