233. Anders Corbett: On “Crafting” Your Gut Microbiome, Probiotics, Leaky Gut & Hormone Optimization

There's a cyanobacteria for oxygen those are found in like Olympic swimmers. That's like how you can identify an Olympic swimmer is by the amount of cyanobacteria in the ground. Really? I think at the professional athlete level they're all looking for ways to legally without using a performance enhancement device but to modify their biology. Anything that they can do to close that last gap. Before and after a stressful event, whether it's like a UFC fight and it's usually saliva, stool, whatever they'll give me. And I measure how those bacteria change. And I'll try to correlate the changes I see in the profile to papers that have talked about this bacteria does x-y-n-z. I know that there's enormity of connections between the gut microbiome and everything all to immune to human performance, to how our mood and emotions work, but never did I understand that we can architect our own microbiome to serve the goals that we have for our health outcomes. There's a list of bacteria that I'm confident that I can isolate from a lot of different people. So I present someone with like a menu like hey this bacteria does this, this bacteria does that. Like which ones you think would be valuable for you. There's a lot of people listening to this podcast. What benefit could they derive from working with craft microbiome to actually go in and re-architect the flora in their gut? There are changes in the gut that happen years before the symptoms develop. And one of the easiest things you can do is... Hey guys, welcome back to the Ultimate Human Podcast. I'm your host, Human Biologist, Carrie Breckow, where we go down the road of everything, anti-aging, biohacking, longevity, and everything in between. And today's podcast is going to be a fascinating podcast. I mean, first of all, because I am deeply, deeply interested in this subject. I never in my entire lifetime knew that the gut microbiome not only could... I knew that it could serve you, it could degrade your performance. I know that there's enormous... there's a normity of connections between the gut microbiome and everything from autoimmune to human performance, to how our mood and emotions work, but never did I understand that we can architect our own microbiome to serve the goals that we have for our health outcomes. And that is the most fascinating thing that we're going to delve into today with our guest, Andrews Corbe. Welcome to the podcast, my friend. Thank you for having me. And there's an interesting theme that runs through a lot of my podcasts. And I find that the most impactful, purpose-driven, passionate people, at some point in their life, they solve the problem. And I know that you were a professional athlete, and you were a world-class rower at one time. Yeah, you were training at the Olympic facility, I think you placed ninth in the you know, in the world competition. And so here you are, you're you have this background as a professional athlete. You were folding shirts at one point at Brooks Brothers. And we're repinting it today. Yeah, let's go Brooks. Yeah, let's go Brooks. And somehow you made it into a fellowship at Harvard University. And now your work has me so intrigued and I am absolutely fascinated by it. You know, we went to the UFC fights. Well, first of all, we're here in Dubai. Right. And we went to the UFC fights and I was like, my audience needs to know about this. I normally don't do this with podcasts. I just I want to read some tidbits from from Anders background and some of the accomplishments he's had with the gut microbiome just to set the tone for the rest of this podcast. So listen to this. If you're not fascinated by the end of these 10 line items, then this is not the podcast for you, but this this blew my mind. Simply by altering the microbiome, he proved the concept first with livestock with 20 before that we went into human trials, 25% weight gain using 400 kilograms less feed consumption. He then on himself gained 25 pounds of muscle in one month using a specific probiotic formulation. He was then featured on ESPN's controversial sports exposé on poop doping and the microbiome performance showing that you could alter the microbiome and significantly significantly improve athletic performance. He worked with George Church, who's one of the world's top genetic scientists using gut the gut microbiome to enhance performance. It worked at the National Science Foundation as a research fellow, Harvard Medical School as a genetics fellow. He actually was able to target testosterone, growth hormone, strength, endurance, and recovery, not just gut health. And you know in 2012 he completed the world growing championships as we as we talked about. And you know many of his competitors have raised millions and millions of dollars, but he went this direct to consumer route with these experimental probiotic formulations and has had astounding success. So I am, first of all, I want to gain 25 pounds of muscle in one month. So we're going to talk about that for sure. But tell me a little bit about your your journey and and how you go from folding shirts at Brooks Brothers to being a research fellow at Harvard University. I got done rowing and I realized I'd work my body really hard, but I hadn't worked my brain. And I at the world championships I realized that I was in amateur and all the other people from the other countries were professionals. I realized like you know what I don't want to put another four years in and try for the next Olympics. And so I moved to Boston with not really a plan and I walked into Brooks Brothers, I got a job. And then I joined a club at MIT called Igem, which is an international genetically engineering machines team. And I had really like no lab experience. Really? Yeah, I just sat in the back. Because you're very smart guy, man. I pressed you on some of these topics. Yeah. I consider myself pretty astute with the gut microbiome, but you've forgotten more than I'll ever know. Well, this was a cell to cell signaling. It was like my first interaction with synthetic biology. And it was run by this guy named Ron Weiss. And the club was great. We competed at the something called the world jamboree. I was like a wallflower on it. But I got an email from the professor at MIT. He's like, hey, like you know, you should take this graduate course. And so I just started showing up at this graduate course with no lab traded. Right. You know, and I got put with these cool guys from the MIT Media Lab and bioengineers and a bunch of crazy people. And then I stumbled into an internship as a bio safety officer intern. And the whole time I'm working at Brooks Brothers, and one day George Church walks into the Chestnut Hill Mall. And I see him. And I just read his book, Regenesis. Yeah. And I went out and I was like, hey, Mr. Church, I'm a big fan. And he said, put yourself in places you don't belong because that's where you learn the most. He just gave you the advice right out of the game. Yeah, well, we had a little conversation. He's like, son, put yourself in places you don't belong because that's where you're learning. He's a wild, that guy's wild. Yeah. And totally focused on the science just. No, no, he's a not. Yeah. And like he travels in the same clothes with just a laptop. Really? Yeah. A lot of these brainiac scientists are, yeah, there's no fluff. It's all just, you know, intentionally focused on their craft. And like two weeks later, I still had my ID pass from being a bio safety officer intern. And I got through security and I brought some cookies and I told the secretary, I'm oh, I'm one of George's old students. I just want to come say hello. And she gets me a meeting that day within minutes. And I say, hey, I'm here. Can I have a job? At Harvard. At Harvard Medical. Yeah. The premier genetics lab in the world. Yeah. And he walks right out of the office. So you get this guy a job. Really? Yeah. And the secretary introduces me to a postdoc at the time. And it was, CRISPR was new at the time. And CRISPR is the gene. Yeah, gene editing. And gene editing. She trained me how to do gene editing on Georgia's own stem cells. Like, you know, like how to like design primers, how to do transformations, how to do gels, which I was terrible at. She was always pissed at me about it. I couldn't run a gel to save my life. But I had a do sequencing, had to work with all these different companies that the labs are part of. And then the second postdoc I worked with heard that I had been a former lead athlete. And eventually we convinced Harvard to send us to the real Olympics to do a sports genomic study. And, and well, first of all, what is a sports genomic study? But before you answer that, I want you to explain to me in my audience like we're five-year-olds. Okay. How does your gut bacteria make your muscles stronger? I mean, you know, because I, because you know, my first foray into, into really being fascinated by the gut microbiome was years ago, Dr. Pearl Mottor wrote a book called The Gut Brain Connection. He wrote another one called Green Brain. It was the first book that really drew my attention to how foundational the gut microbiome is. And the, these trillions and trillions of bacteria and how they're actually not just digesting proteins and carbohydrates and nutrients, but they're actually signaling molecules. They create serotonin, dopamine, they drive behavior, they drive mood. You know, we, we know now that your gut microbiome sort of gets what it wants. It's, it, it has mechanisms to signal the brain to have sugar cravings and other things. And, and it's, it's interesting because, you know, we think that we're in control of all of our choices, but very often we're not, you know, the gut microbiome is in control of a lot of the choices that we make. But I've never thought about the gut microbiome. And this is what's so fascinating about your work. I've never thought about the gut microbiome as being something we can use or leverage to improve our processing speed, our memory, our focus, our concentration. And the last thing I thought would be, you know, athletic performance. So talk a little bit about, you know, as if we're five years old, how does the gut microbiome improve athletic performance? How many, how did you put on 25 pounds of muscle in a month without? There was this crazy paper from, I think 2016, February 2016, about how people in Malawi famine victims and it took their microbiome, it did a fecal transplant into mice and it took the microbiome from a, a westerner and put it in the, in a different mouse, they fed them mice the same amount of food, the same amount of water. And the Malawi and mice, uh, became malnourished, like lost weight, even though they were fed the same amount of calories. So you took the gut microbiome from someone who was malnourished? Yeah, someone else. Yeah, yeah, yeah, yeah, yeah, yeah, and, and, and, and fecal transplanted into the mouse. And then you have other gut microbiome from a westerner, from a westerner, yeah, same diet, same diet, okay, same water, same everything. And the western mouse gets obese. Wow. Right. And they repeated this a lot of times. And the Malawi and mice, uh, with, wouldn't grow, right? They were stuck on a poor growth pathway or whatever it's called. And so they found the single bacteria and they gave it to the Malawi and mouse. And then all of a sudden it returned to normal growth patterns. Wow. Yeah. With a single bacteria. So, so by taking the gut microbiome and sequencing the different types of bacteria and looking at different types of levels, it's almost like a dial, right? You dial up certain bacteria, you get one result, you dial it down, you get a different result. So they dialed up the bacteria, uh, you know, in from the westerners and, and, and all of a sudden, these mice recovered on the same time. Yeah, they returned to like normal. And that's kind of what happens when you get poor sleep, you have poor diet, you know, you're overweight, like these growth hormone pathways in your body, they don't function, they get blocked, right? There's, um, and so it's not really that well understood. But this lactobacillus rotorias, specific substrain of it is able to remove those blocks of any your body can start producing its own growth hormone. Yeah. You know, what's fascinating too is as I get further and further down the road of the gut microbiome, you know, we know that antibiotics wipe out your gut microbiome, and that you should take probiotics afterwards. But when you start to look at how we can actually go into the gut microbiome and specifically select it to different characteristics based on the bacteria. So for example, you know, there are strains of bacteria that are broadly absent in people that have a examines or isis. Yeah. There are certain strains of bacteria that are broadly absent in neuro, neurodevelopmental disorders like autism. Yeah. And to me, that's fascinating. And the, the percentage into the degree to which these specific bacteria are correlated to very specific diseases, pathologies is fascinating to me. Yeah. Because, you know, I think very often in modern medicine, we get it all wrong. We think that things go wrong for no reason, which is why we diagnose a lot of things as idiopathic, right, of unknown origin. But when you think about the gut microbiome, the different, um, the different strains of bacteria as potentially being that root cause, this seems like something we could, you know, we could address mass. There are a lot of papers that show like changes in the gut happen years, but for Parkinson's changes in the gut happen years before you develop some sort of any sort of symptoms. It's like acrimansia and cancer, you know, they're finding these deficiencies in certain gut bacteria. Dr. Mark Hyman talks about this all the time. Um, much higher prevalence in patients that have certain forms of cancer. Yeah. And, you know, I think I'm fully bought in to, to that, you know, but, but we're only at the beginning. Yeah. There's a lot to learn. Yeah. There's a lot to learn. 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Is that fair to say? Yeah. Okay. And then once you have that person's gut microbiome profile, where do you go from there? Do you say, well, what are the outcomes that you would like to have? Yeah. And then you target those bacteria? There's a list of bacteria that I'm confident that I can isolate from a lot of different people. So, I present someone with like a menu. Like, hey, this bacteria does this? This bacteria does that? Like, which ones do you think would be valuable for you? Yeah. And for the record, you're working with LeBron James. I mean, this is not like, this is not voodoo science. You know, he's not doing this in his basement and, you know, in his garage. I mean, yeah. And it's, yeah. So, go ahead. So, you take the microbiome and you have a menu. And they say, you know, I have focus and concentration issues. Yeah. I have a hard time focusing and concentrating. Let's pick a few things. Yeah. But just to be clear, like, it's, we understand like the first tier interactions, like this bacteria. And it's just starting to be this bacteria lives in this part of the digestive tract. And it makes B vitamins. It makes B12 or something. Right? And so, there's a geography issue. And then there's, you don't know if that B vitamin is consumed by another bacteria. Right? We don't know like the downstream thing. So, the philosophy is I just overload with that bacteria. But you are seeing notable results. Yeah. Yeah. Yeah. On blood tests. And, you know, a lot of the clients they do quarterly or monthly blood tests and they'll show like, hey, my B vitamins actually went up this month or my testosterone is up like 300 points or something. Really? Yeah. It just sits at like seven or eight hundred for months and months. Mm. After you've made this manipulation in the back. Yeah. Yeah. Okay. So, let's unpack that. You know, I would love to, to the extent that you're willing to do so. Share an actual story of an athlete that came to you or even somebody that had gut dysbiosis related ailment. Maybe it was ex-emotional psoriasis. Maybe it was, you know, chronic gut issues with digestion, food allergies, food sensitivities. Let's take a real life case that you've had and walk me through what you did from, you know, understanding what their deficit was or their goal was to getting their gut bacteria to how you either manipulated or, you know, cultured their bacteria and then what the result was. So, I guess we can do two examples. Okay. One, I may, originally, all the bacteria sold direct to consumer rice slated from me. And so, there was like strength and endurance and complete. Okay. And so, a friend of mine had a pick line in for years and years. He had Lyme disease. He ended up. Oh, Lyme is awful. Yeah, horrible. Yeah. Harable disease. Any got misdiagnosed and he lost a leg. It was crazy. Oh my God. Yeah. So, a pick line with antibiotics for years. Yeah. Right. Just got no bacteria left. None. And he does blood tests, you know, every half a year, quarterly or whatever it is. And it was like two, it was a little low. And then he, I, what was a little low? His testosterone. Oh, his testosterone. Yeah. And then I give him the craft strength and then it sits at like eight or nine hundred and been there for like four or five years. But when you say I give him the craft strength. So, yeah. I want to, I want to, I want to do bacteria and craft strength. So, you get, you get this tool sample. You look at the microbiome profile. Yeah. Right. I don't particularly find the profile that useful. It's okay. It understands what it tells me what you ate yesterday. Right. What I, what I really like to do is before and after a stressful event, whether it's like a UFC fight, or the world's strongest man or at the Olympics or an MBA basketball game or something. And it's usually saliva, stool, whatever they'll, they'll give me. And I measure how those bacteria change before and after the stressful event. And I'll try to correlate the changes I see in the profile to papers that have talked about this bacteria does X, Y, and Z. And, but in this person's case, with the Lyme disease, it was just like a standard two bacteria, lactobacillus plantarum, and then a substrain that came out of South Korea. And then lactobacillus rotorye, that a substrain that has been shown to lower interleukin 17 alpha. And so your leadic cells and your tessies get larger. And then you produce your own testosterone. Wow. Dude, I mean, there's not a man listening to this podcast right now that's not like, where do I get that bacteria? Look at those big balls. Yeah. Yeah. Yeah. Huge balls. Yeah. You can't see big balls on a podcast. No. You can on the ultimate human. We're tough. So Lyme disease ravaged from antibiotics. Yeah. He's a great experiment. And get the bacteria. And as you repopulate the gut, yeah, is testosterone. Now, the main challenges of wiping out the gut microbiome are way beyond just a decrease in testosterone. I mean, you know, Lyme patients have crushing fatigue. They have muscle soreness. They have brain fog that you can't imagine. Yeah. They have poor focus and concentration, disrupted sleep patterns. And I believe that the vast majority of this does tie back to the gut, meaning that between the virus and the co-infections, the parasitic co-infection and the bacterial co-infection, you have this myriad of consequences that very often, modern medicine, doesn't link back to the Lyme disease. No. And in your friend's case, it sounds very sad. He had an amputation. For the misdiagnosis. For the misdiagnosis, which is why medical errors still the third leading cause of death. It's not that doctors, you know, I want to not sound so harsh. Like doctors are potentially doing things or they're making mistakes. It just shows you, even as far as we are advanced in modern medicine today, the positive of understanding of true human physiology. Yeah. We're really just scratching the surface. That's one of my biggest motivations is I like see this technological advancement. But I don't see the human advancing. And I thought like this would be a good product to like get us off our phones and get us. So, so so after repopulating his gut bacteria, how did you decide what to give him? Mainly is I didn't want to hurt the guy. Right. He's been through a lot. I'm like, I thought I would give him most benign back to like lactobacillus strains. Right. It's in yoga. Which were wiped out, I'm sure, because yeah, it's in yogurt and kefir, but it's a very specific type of bacteria that has very specific function. And so I imagine these bacteria as like factories, right? They just go into your body and turn on as a factory. And you know, they turn on by like the doing something called RNA sequencing. So, you know, which genes in the bacteria actually turned on in the body versus in the in the dormant state. Right. And we know that that our genes don't necessarily determine our destiny. I mean, our genes are sort of the blueprint. Yeah. Where they say that your genetics load the gun, but you know, your lifestyle pulls the trigger, right? And so in this case, you you culture these strains of bacteria. He starts to take the probiotic. Testosterone recovers. Yeah. Incredibly. How about the other myriad of you know, consequences he was dealing with? I call the myriad of other symptoms. Later that year, you know, I'm friends with the guy we go run a flat mile together. You know, he was able to return to athleticism, which is nice. And you know, he's a family man and you know, this hat he's can, you know, happily married and all that stuff. Yeah. You know, he's just living a normal life. He was a see I look up to him a lot. He's really highly educated. Been a venture capitalist for like 15 years. Yeah. You know, just like that struggled. So this changes life. Yeah. Yeah. And and I love the I love the concept of you take my got bacteria, culture and expand those. And, you know, so if I did a course of antibiotics, let's say you had my bacteria banked. Yeah. When I'm done with the course of antibiotics, you could give me back my own bacteria. Yeah, that's a really big deal. And I do that for a lot of people as I and a lot of people they'll have surgery and I'll do exactly that. They take the unbox and then they get their own bacteria back to them. I mean, I that that's fascinating to me because you know, we're trying. There are I mean, there are lots of good pre pro and postbiotics that are out there. I mean, there's something that I really trust and I recommend to allow them. Of course. Yeah. Community. But the I always say that, you know, there's no matter what anyone tells you, there's no better hormone bacteria than when the body produces on its own. Yeah. Right. So if you could take my bacteria, bank them. And then if I did a course of antibiotics, repopulate my own gut with my own bacteria, there's I mean, there's no better targeted way to restore the gut microbiome. And there's there's even like weird papers that are published about like the bacteria you get a birth and the birth canal through the breast milk seems to have like seniority over the other bacteria. So you can like take that bacteria and it'll organize everyone else like time to get in line. Wow. And like the first performance bacteria actually was from a World War I veteran. And he was in the trenches and everyone in the trench like died or got super sick from dysentery. Except this one guy, he was healthy, he was fine, no problem. And so after the war, they've tried to figure out what happened. And so they isolated an E. coli strain. Facing that even had the impetus to do that back then. It was a scientist or almost a hundred years ago, more than a hundred years ago. That's what I mean. And it's still sold today. You can still buy it. Wow. It's called Mutaflore. Wow. And you can buy it. And it's still the same isolate of that same bacteria from that World War I veteran. Wow. And to this day, it's a concert. It helps constipation, helps diarrhea. It helps all sorts of digestive issues for travelers. It's a great product. So so where do you see this technology that you've developed going? I mean, eventually, do you see it as like literally like a menu? You could come in and say, here are the challenges that I have. I have poor focus and concentration. I don't sleep well. I've got intermittent diarrhea and constipation. I mean, my gut's constantly bothering me. I get cramping and get bloating. And you could dial up or dial down certain bacterial strains and repopulate the floor in a way that would address those symptoms. Yeah. I'm trying to, well, it's, I have a foundational model for someone that's not doing that well. And then I go up different levels depending on how customized you want to be. Okay. Right. And yeah, tell me what what exists today. So today, if I send a stool sample in, what are the possibilities that I could get back for that? And I'd love to see this. Yeah. It's on the web because I want to go through the menu myself. Yeah. Because I've got some things I'd like to get. Well, it's, it's on the website. And under the about us page, there's like the studies we can whip back to here and what study are cited on there. And for the most part, I can isolate those from people. And there's anywhere from bone density to serotonin dopamine. There is Androgen bacteria. And the cyanobacteria for oxygen, those are found in like Olympic swimmers. You know, uniquely, that's like how you can identify an Olympic swimmer is by the amount of cyanobacteria in the, really? Yeah. You can like identify a lot of different sports by like, so if you actually just saw nothing other than somebody's got microbiome profile, you could say this person has a professional athlete. At the Olympic, you know, level. Yeah. With other sports like, you know, professional basketball is a little more challenging. But like, I did saliva sampling with UFC fighters and that the world's strongest man. And at the world's strongest man, I did four tests before, during and after the competition. Okay. And I could tell which athletes had competed two weeks earlier, based on the amount of bacteria that eats lactate inside of them. Because there was still food for that bacteria. And that means that it had cleared their body. Like the lactate was still being consumed by the, it's a bacteria called Villanilla. And lactate is obviously what's produced when you're. Yeah. Yeah. There's some controversy on lactate and exercise and things like that. I'm not, you know, I'm not an expert on that. But at least every athlete I competed in Europe's strongest man two weeks earlier had elevated levels of that bacteria. Wow. And you can be like, that person is tired. Right. Yeah. Or and then with the UFC fighters, we did saliva sampling again four times. But the most interesting difference was four hours before the fight and then within five minutes after the fight. So as soon as they're done, press, get to the locker room and take a saliva sample. A bunch of blood and saliva all mixed up. They were actually willing to sit down and do a blood draw right up to fight. Yeah. Well, with the, you know, with this guy named Forest Griffin tells him to do it. Yeah. Yeah. They do. I love forests. Yeah. Shout out to Forest Griffin. You did it to do this right now. It's like the last thing on my mind. I've just gotten kicked and punched in the face and like, maybe I won. Maybe I lost. But you know, you know, like, can I get some blood in that was a while week. So you, so you sample these. But I want to get back to the practical applications for like my audience is listening. So because all of us have something that we're, yeah. Well, I'm just talking about the stuff because that's how I get data to isolate new bacteria. Okay. Like I go, I love the stressful event measuring that. Yeah. And then that informs me what is happening to a body that goes through that what bacteria, what food is available, what populations go up or down? So I want to go back to this concept of targeting the gut microbiome again. Okay. I'm, I really am fascinated by this. Yeah. And we got a menu. And we got a menu, which I'm going to read because I'm also fascinated by this. But so talk to me like about what you did for LeBron, like how did, what would have been his interest in altering his gut microbiome? Because things seem to be going pretty well for him. Yeah. Right now. Yeah. I'm happy to talk about it. But it's been, he sent me a, you know, I got connected through mutual friends. He sent me a sample in the mail. And I worked with this trainer mostly of understanding how he is recovering mostly. And so, and through work with other NBA players, it's quite a challenging season for travel and sleep is like a big issue for these guys. Yeah. And there are big differences in off season versus in season microbiome content. And so for him, it's specifically for recovery. Yeah. To say he wanted the, the best gut microbiome. And, you know, again, what's fascinating to me is you can go into someone who is a professional athlete because I think at the professional athlete level, they're all looking for ways to legally. Yeah. Without enhancing, you know, using a performance enhancement device. But to modify their biology, right, whether it's through red light or hyperbarics or, you know, sleep or, or, you know, eating very clean foods, anything that they can do to close that last gap. This is just a right. Yeah, yeah, to close that last gap. Right. So, so when you, and most of us are not looking for that elite level of performance. So I want to bring this back down to, you know, what this means to working for. There's two types of these bacteria. The bacteria that can impact day of performance. And then also over, you know, day to day maintenance. Okay. Love is on your body. What is it specifically doing? Is it reducing the lactate threshold? Is it improving, you know, oxidative phosphorylation? I mean, is it enhancing the, well, the, the, the, the, what is it that's having the impact on the, the, based on a number of papers, the villain, all the bacteria sits between the blood and gut barrier. And it pulls the lactate out of the blood and consumes it in the gut and the x greets another metabolite. Wow. Yeah. Which is pretty cool, right? Yeah. Yeah. And so, you know, overloading that over time, I think would help recovery. Yeah. Yeah. No, help recovery here. Actually, because, you know, the performance to grades as you get into that lactate threshold, you know, the, the longer you can maintain aerobic respiration. Yeah. Right. We know that there's aerobic and anaerobic respiration. So, you know, as you get anaerobic, you know, your muscles start to burn, you know, hydrogen ions build up. So all kinds of things that are going on that are, that are actually causing a degradation in performance. So highly conditioned athletes, higher VO2 max, better circulation, shuttling, oxygen and carbon dioxide back and forth from the lung to the tissue. Is what really makes the difference between someone who can perform well athletically and someone who can't. Yeah. So, but what's interesting and fascinating to me is I've never inserted the gut microbiome into that. Yeah. To think how could the gut microbiome push you further, either extend how long you can stay in aerobic respiration or help you recover from anaerobic respiration faster by consuming these byproducts of those processes. Yeah. You know, lactate, pyruvate, these, these metabolic byproducts that are degrading performance. Right. So in my biological mind, you know, if you have these byproducts that are degrading performance and there are bacteria that consume those byproducts. Right. Yeah. You have an increase in performance. Right. I mean, that makes you just describe my whole business. Did I really? That's my whole business. This menu is pretty fascinating. So these are, these are strains that are clinically proven to enhance certain areas of performance. I won't go through a lot of these names, but bacteria one, let's just call it, found in the gut of elite athletes and acts as an energy source for the body. Yeah. Increasing your ability to gain muscle mass, improve exercise performance, and exert anti-fetigue effects. There is another strain that increases your ability to gain muscle mass more effectively and improve digestion. A separate one that increases your ability to gain muscle mass, improve exercise performance. Just right there. Enhancer gut barrier and improved digestive system and gut function. The gut barrier is another mass that we know that leaky gut, this sort of single cell layer that lines the inside of our gut and keeps our outside environment separate from our inside environment. Yeah. I mean, a lot of people don't realize that's only a single cell layer. Yeah. And the gut microbiome influencing that cell layer to prevent leaky gut, which has its whole set of downstream consequences, inflammation, calling the immune system, all kinds of things. Boosting oral health, relieving irritable bowel syndrome, and improving cholesterol when combined with other probiotics. Yeah. And then this one is an all-around strain that promotes gut and immune health. Reduces cholesterol, relieves irritable bowel syndrome, reduces allergy symptoms, prevents and treats vaginal infections. I mean, that's, I don't have vagina, but all the other ones I want to do, relieve symptoms of digestive disorder and promote overall gut health. Yeah. Boost oral health, relieving irritable bowel syndrome, improve cholesterol, treat constipation, reduce inflammation, improve the immune system, improving... Yeah, and there's more and more papers for breast and every day. Yeah. So... More and more published every day. This is incredible. So jumping out of the elite athlete, and I love how you're called craft microbiome, because you're sort of crafting the microbiome. Yeah. So it's a great, great marketing tool there. But the average person listening to this podcast, if they were to close their eyes and say, here's my wish list, you know, and it started with things like, you know, gut dysbiosis, because the vast majority of people do have something that they would love to fix about the gut. Total. Total. Maybe it's gas, maybe it's bloating diarrhea, constipation, irritability, cramping, you know, bloating and inflammation. Yeah. Where did they start? What would a stool sample arriving to your lab look like before it turned into a probiotic for them? So I take that as much stool or saliva that covers a penny. Each of those bacteria has a different growth condition. So meaning some bacteria like to grow with oxygen, some like without oxygen, some like because these things are alive, they need to eat. So I need to put different ingredients to, you know, kind of farm these bacteria. And so once I dilute the bacteria and make these growth plates, colonies will grow on the growth plates. Little tiny single cells or, you know, not, you know, but enough that's a single isolated bacteria. I take that bacteria, I do genomic sequencing of it to identify the strain, the substrain, and then any interesting genomic sequences within it. Once I have that ID verified, I put it in a media jar or a bioreactor with the same growth conditions that it, how I found it originally. And then it grows large quantities. I freeze dry the bacteria. It's like a goo at that point. So it turns into freeze dried bacteria. And this is their bacteria. It came from them. Yeah, it came from them. And then I saved some of it and then I put the rest in these capsules and then ship it to you. Okay. And then, but you have it banked. Yeah, I do. So you can continue to grow that bacteria. Because, you know, I have a number of professional athletes and folks that I work with. Several of them just give you one example. I have a very well known athlete that had to have some dental work done. And because of the extensive dental work, they put them on a very powerful course of antibiotics. He actually did develop a jaw infection, which required another course of antibiotics. And there was noticeable degradation in performance. Yeah, after this. Pretty amazing, right? Yeah. Yeah. And we struggled for a while. We fixed it now, but we struggled for a while to repopulate his gut. I mean, I tried all kinds of things. 38 terap biocomplete 3. My standard mechanisms for re-inoculating, you know, the gut. It took much longer than we originally anticipated. But if you had it, it doesn't even need to be an athlete. I want to actually just stop talking about it, lead athletes. Because most people are not looking to close that last two tenths of a mile in performance. But, you know, just average mom and dad, you know, goes and gets some, you know, dental work done or for whatever reason goes on a massive course of antibiotics, wipes out their gut bacteria. Where would you start with someone like that? I would try to find something called the phyto-bacterium infantis, which by most indications is the first bacteria that inhabits your gut. And it's what I was talking about earlier for that seems to have seniority over the other bacteria to tell them what to do to organize. And that seems to like settle down a lot of people's guts. Wow. Yeah, it just kind of settle things, you know, get them, you know, like just stable. And then from there, after a few months, try to like build it up in there. If you want protein to build lean muscle, but without the caloric impact or need to cut, you need perfect amino. It's pure essential amino acids, the building blocks of proteins in a precise form and ratio that allows for near 100% utilization in building lean muscle and no caloric impact. So we build protein six times as much as way, but without the excess body fat we normally get during bulking. This is the new era of protein supplementation and it's real. If you want to build lean muscle without having to cut, you need perfect amino. Now let's get back to the ultimate human podcast. So when you, when you, when you look at people that have severe gut dysbiosis, there's a lot of people listening to this podcast that have been diagnosed with irritable bowel syndrome, ulcerative colitis, divertic colitis, Crohn's disease. Right. A lot of inflammation. Yeah. They're all inflammation. Theitis is inflammation. And in those, if they're listening to this podcast right now, what benefit could they derive from working with craft microbiome to actually go in and rearchitect the flora in their gut? The goal for me always is just to start small, right? And just start with like, does this help you or not? Yes. Because you should be able to feel better within a few days, right? And, and from there, really just within a few days. Yeah. Usually, that's usually the feedback I get. Like, hey, like I'm, you know, things are quiet. I'm sleeping better. I'm feeling better. You know, I'm, and so, you know, I like to, I'm very cautious. And so I like people to say they're feeling better. And then we can start isolating new and different types of bacteria for their own goals. Right. I like the consumer to kind of drive the, oh, you consumer does too. I mean, there's nothing, you know, right. I don't want to tell more. And like, you need this, you need that. I'm like, no, like, hey, what's, what's important to you? Yeah. Right. And what you're doing in the lab is taking their, their goal. Yeah. And sort of selecting the bacteria. That's the thing that's so fascinating to me is that we're now, because we know that, um, for example, we, you know, we, our gut bacteria will methylate, uh, trip the fan and amino acid into the neurotransmitter serotonin or phenylalanine and tyrosine into the neurotransmitter dopamine dopamine is the main driver of behavior. Serotonin is one of the main drivers of mood. So you could see that if you're, if these conversions are off, yeah, you have issues with mood and behavior. Yeah. Now, I've always looked at genetic methylation, you know, the deficiency that impays. And that's the bleeding edge of the microbiome right now. Right. If finding out which bacteria help turn on a turn off specific genes in your human DNA. So if I could add targeted supplementation for the deficiencies that these people have, to targeted probiotics, right. That to me would be the holy grail. Yeah, it's, it's coming. Yeah. There's research published now about that exact thing. But you're already doing it. That's the fascinating thing you've had success in these. Yeah. Yeah. Um, and so I, I, you know, take the take this test. I tell you what my goals are. You get my bacteria. And now you're trying to select these certain strains like, um, uh, to improve my cognitive function or what have you. Well, let's, let's actually talk about, uh, some of those conditions, diverticulitis, ulcerative colitis, Crohn's disease, irritable bowel syndrome, all of these conditions mainly all have the common theme of inflammation that got where do you start with someone that has one of those conditions? You, you sequence the microbiome. Mm-hmm. And then you're targeting the bacteria that will help them reduce inflammation. Yeah. Just the most benign and most, uh, you know, quieting bacteria. And that's usually a bifidobacterium, like, you know, one of the animalis or infantis or whatever it is. I just said the most benign bacteria I can from them. And the sole focus would just be reducing inflammation. Okay. That's the soul that would all be my total focus. I wouldn't try to, you know, get like churn you into D1 athlete right off the bat. Right. Yeah. That's not their goal. I mean, they want to be out of pain. They want, they don't want their day to be centered around their gut. Yeah. And, and it's one of those quiet things that just, you know, it's in the back of their mind all the time, you know, when your gut is sort of determining your choices, you're not determining your own choices. And I have hundreds of clients like this, you know, their day is centered around the condition that they're dealing with. Right. Yeah. You know, like they're literally when they get to a public event, they're thinking, okay, where's the restroom? Yeah. I need to be able to access this. Yeah. I call and talk to all the clients right now. I'm sure that will change. But the, you know, I ask certain questions like people that tell me they have allergies. I know I can't give them lactobacillus. Right. Right. I know that causes problems for whatever reason. Yeah. I also ask can you eat garlic and onions? And like, no, I can't eat garlic and onions. So that will like change a whole bunch of different bacteria that I get them. And I'm not sure why this is the case. Yeah. But I know if I, we know that correlation. Yeah. It's like, no, you know, okay, now I go and usually the Bifidobacterium are the best choice just because of all the numerous symptoms that they've talked about. I'm super excited about this. In fact, if you want to be sent a message to my team at info at theultimatehuman.com. Let's go. Because I really like to do these real world trials, if you will. And see if we can address their primary challenge and achieve their primary goal. Because I know that the clients I have, for example, that have ex-month psoriasis. A lot of what we do is focused on the gut microbiome. But we're not as selective. And you know, it's a little bit of guesswork there because you're throwing the strains in there, not knowing what they have, an overgrowth of what they have, an undergrowth of, and which populations that really need to target, whereas you can actually target those specific populations. That's what I find fascinating. And eventually we get there, but we're getting there, you know, it's like spaghetti against a wall, you know, to see what's to it. Yeah. You're getting there by putting enough in that eventually the gut returns to, it's homeostatic. There's a few customers who were like, I don't care what it is, give it to me. I'm one of those. Most of my VIP communities like that too. Yeah. This is work or not. Yeah. I don't know. I mean, there's very, you know, this is the low risk proposition. Right. It's your own bacteria. I came from you. Exactly. That's what I love. You know, I have a saying I say all the time, more of what cod gave us, less of what man misses. So if we can actually go into our gut-given, you know, strains of our own bacteria, sorry, you know, to solve the challenges. And by the way, this isn't voodoo science. I mean, they have mapped very specific bacteria, eczema and psoriasis, for example. There is a very strong correlation between deficiencies and certain strange. Yeah. You're aware of that, right? Yeah. And which strains are those? I can't tell you off the top of my head, but I know the papers exist. Yeah. And so could we, and you know, this particularly troublesome when I get really, really young children that are suffering from this, because there's nothing worse than being a mother, father, and your child is suffering from this skin condition. And the only option you have are steroids, you know, that cortigo steroids and any inflammatory. And you're stuck in this really, you know, it's like the rock in the hard place decision because you want to help your child. The only thing that gives them some relief is something that you know is borrowing from their future. Yeah. And you know, they're going to be further consequences. You just want to help them right now. You know, it's why we stick an iPad in front of our kid to calm them down because we're in a public place. But, you know, and I really want to offer some hope to them that, you know, this may be the answer may lie in sequencing the gut microbiome and targeted probiotics to give them a lifetime of relief. Permanent. Yeah. The two important technologies here are the storage of the complete biome. So as the technology improves, we can always go back to the original sample and isolate more and more and more from that original sample. Yeah. So as our skill increases, that original sample becomes more and more valuable. Now tell me that you're using AI. I've done it for some evaluations of a large groups of people that I'm testing. Right. To see patterns that I can't see. Yes, exactly. Over the last 20 years in human biology, one compound I've trusted again and again is NAD+. It's critical for energy, focus, and cellular repair. But your levels drop around age 30. I used to administer NADVIVs in my clinics, but now I take Roe Nutrition's Liposomal NAD, the first oral formula that actually works. Their advanced delivery tech gets NAD straight into your bloodstream. I take one teaspoon daily and the results are real. Clean energy, sharper focus, and better recovery. You can try risk-free with the ultimate 15 code at checkout for 15% off. Just put in ultimate 15 at checkout, you'll receive 15% off and your cells will thank you. Now let's get back to the ultimate human podcast. So let's touch on that one for me. Yeah. So Eximos surrises. We know that there are deficient bacterial strains. If you were to get a stool sample from one of these children, what would be the next step? So my process would be to do deep into the research, to try to find some sort of metabolite or groups of metabolites that may be overproduced in the gut, underproduced, and it'd be my intention to either find bacteria that it's a lot harder to get rid of the bad bacteria, but what we can do is out-compete the bad bacteria. And so that would be my goal is to find the metabolites that may be causing the Eximos surrises and either have them consumed or overproduce the beneficial metabolites. Yeah, because we know that it's not a complete guessing game. I mean, there's quality data on the missing strains. And I think what you just touched on, I want to make sure it doesn't get missed, is that you say out-compete because we know in a healthy gut microbiome, there are always pathogenic flora. We have healthy parasites and every single person has a chagela and salmonella. Exactly. Also, it's crazy stuff. We all have SIBO going on just not at a level of a symptomatic, right? So we all have bacteria on your skin everywhere inside of you. Exactly. But homeostasis is where you have a proliferation of the healthy bacteria. And it's not just that they're there to do their role. It's there to also suppress the negative effects from some of these other bacteria. And we know that things like highly processed foods, refined sugars, grains, genetically modified foods that have pesticides or parasites and secticides, things like that actually do wipe out and sometimes benefit bad bacteria. And so the idea that we could actually repopulate the gut with the beneficial bacteria and let that do the policing, right? Yeah. Let the bodies normal homeostatic biophysiological process keep these strains in check. Variety is good. And there's like a collapse in our western stomachs about the variety of bacteria that we have. It's just continually going down and down and down everywhere. The more highly processed foods we eat, the more we live in a sterile environment. Yes. The more like all these things are just killing our bacteria. Yes, right? And so your next step would be, again, back to the X-Men's horizons, we would try to find the bacteria, the deficient bacteria, repopulate those and specifically isolate the strains that we know are pro-inflammatory and use beneficial bacteria to restore those. Yeah, so try to out-compete those pro-inflammatory bacteria. Geography is starting to be an important issue too, like we're in the digestive tract there. They live. And also try to produce as many anti-inflammatory metabolites as possible. Can you give me some stories without names or identifying people? Non-ethyletic stories where you actually had someone with a condition related to the gut. It could be irritable. Balsyndrom, you know, diverticulitis, ulcerative cliase, Crohn's disease. One of these conditions in the gut and you saw miraculous. Yeah, there's this actress that's had two or three fecal transplants in her life. Advisible or not, I don't want to say, I can't say. Yeah. But to this day, or maybe not to this day, but she'd been dealing with these issues. And I took the sample, I evaluated it, I produced a report, and then it turned out I just need to continually reduce the inflammation in her body. And so I just made extra powerful inflammation reducing bacteria. So you took her bacteria, culture and grew it, and you expanded the flora that actually helps to reduce inflammation. And what was the consequence? She had been losing her hair, she had been losing weight. And I know these actresses want to be skinny, but it was getting a little crazy. And because of the reduced inflammation, her hair started to grow back, she got some movie roles, things like that. She just felt better. Which was the number one issue. Okay. For how about anything in the realm of one of these gut dysbiosis conditions, like an ulcerative glitis or diverticulitis front, have you had experience in manipulating the gut bacteria with positive outcomes there? It's in a side life. I did, I did all the chivalry in a side life. I did all the so shady. I did all the training to become a Pilates insurrector. Did you really? I did pass on. Dude, I've done two days of Pilates and I could move when I got up this morning. And all I did was the core stretch thing. It was great. It was great. So I'm so bad. So when I was done rowing, my body was a little broken. And so Pilates helped me put back together. So I did all the training. I did and I'm do all the teaching so I don't. I'm not certified. But the teachers warned you like, hey, if a customer, if a client comes in and it becomes your job to fix them, you're never going to make that customer happy. And so I've taken that approach to with the company. I can try to help, but I'm not sure I can fix everything. So I try to like, is this something, how long have you been working on this? What's your doctor saying? How can I be supplemental to what you're doing? But you had a supplemental role in helping people reduce their symptoms or put these things into remission. Do you have cases where you can say, hey, this person had XYZ condition, post targeted microbiome. That's very exciting. I don't want to pay you in like not giving yourself enough credit here. I'm trying to give you some credit because I really believe that this is a massive frontier for medicine because there's so little focus. There's a lot of focus on the microbiome, but there's so little focus on the individuality of people's microbiome and actually taking their microbiome to culture and expand it to address the conditions that they have. I mean, obviously on that list of, you know, that wish list, if you, whatever you want to call it, a lot of those things on there, I mean, check the box. Probably 70% of my audience has one of those that they would love to have addressed. Yeah. I do have that you're addressing it by using their own bacterial strains to me is really fascinating. Yeah. It's a wild world. Yeah. It's wild. So you have had success. But I'm also very cautious not to go against the FDA. I'm not intended to treat cure preventative disease. And I don't want you to make a medical claim. But yeah. And the fact that you have been, and I'm, I tried to be cautious about that too, but people need information. And it's sad how frightened we are sometimes to speak about successes that we've had. Maybe we don't want to use the term cure or treat prevent. Well, but like, for example, someone has a high glucose, they wake up their glucose at 200 or something outrageous. To solve that problem, it was first doing oral sequencing to find out, and then which bacteria actually living in there, and then finding papers showing that you're 70% likely to be pre-diabetic or diabetic from pure root paper if you're missing these bacteria. Yeah, it's exactly what I'm talking about. Right. And then so the process was like, okay, how do I actually develop a product for this problem? And so it's like, isolate the bacteria they're missing. First from me to try it if it helps them. And then eventually, maybe if I can keep trying to, because sometimes bacteria don't want to grow. No matter if it shows up in the sequencing, sometimes it doesn't want to grow. Right. But then making like a mouthwash, like, hey, like let's try signaling to the brain about 10 minutes before you eat your meal, swish this bacteria around your mouth and spit it out. That didn't work. Right. But then finding a bacteria that actually consumes glucose and loading the person up, like take this 90 minutes before a meal, it eats glucose. And let's, I was wearing these glucose monitors for a while. And I would go to Wendy's every day and eat the same meal. Oh, dude, you're killing it. It was horrible. It was horrible. But I go to Wendy's every day, eat the same meal. I take the bacteria and I'd trial it. Yeah. Right. Until by glucose, well, then spiking crazy. Yeah. Oh, I tracked it, I guess for a few weeks where the glucose pre-supplement would spike to like 120, 140, something like that, and then post taking the bacteria gets up to like 115, 120. Oh, my God. Now I've handed off to the client and now his glucose doesn't spike. Yeah. See, this is just fast. Now we're getting it somewhere. Right. This is what I was after. I'm, and I understand we got to dance around the FDA, but we're going to get some specific answers. Oh, God. Because I think if you're able to eventually get enough data to crack this code, the gut microbiome is so foundation, it's 70% in my opinion. I mean, there's a reason why 70% of your immune system is right outside of your gut. Because that's where all the action is. Mm-hmm. There is also, in my opinion, an enormous body of data that says that the first domino to fall in the sequence of multiple chronic diseases is gut dysbiosis. Yeah. So what happens is we have severe gut disruption, whether it was antibiotics or whether it was infection or whether it was just poor food over prolonged period of time, wiping out our gut microbiome. And that was the first domino to fall. And now 50 dominoes later, they've got their first autoimmune disease. 50 dominoes after that, they've got their second autoimmune disease. We know that early onset, Alzheimer's, dementia, early onset, cognitive decline. That's everybody's greatest fear. Yeah. We know now that that doesn't start when you're 75 years old. No. It starts when you're 35 or 40 or 45 years old. Right. And so the possibility to intervene from a preventive standpoint, the possibility to address, I won't say treat or cure, but to address ailments that you're suffering from now, that we know have strong evidence or linked back to the domino microbiome. This is the whole reason why I brought you on this podcast because I don't have the wherewithal the knowledge myself to know specifically how we do it, but I do have a keen appreciation that if we figure that out, yeah. And that is potentially the panacea. In fact, you know, this woman that just passed away at 118 years old. Oh, you saw the paper. Yeah. Yeah. She's all the paper. Can you talk about that for a second? Yeah. Yeah. Because that's validating about everything that you've talked about in this podcast. Right. What was unique about her? I believe she had a high percentage of the phyto bacterium. Exactly. Which is a genus inside of her, a genus of bacteria. And she had it relative to someone, you know, at a mid life age or something like that. Yeah. They said a 35 year old. Yeah. That's what we know. Yeah. At 118. Yeah. So you can't just overlook that. Right. Right. So and I believe too that, you know, when we look at Blue Zone studies, a lot of the data was regional, meaning if you took a centenarian from Sardinia that was eating that, you know, genre of foods and what have you. But if you had 50 years earlier, put that person in a different area of the world, they would have had a different outcome. Yeah. Because they're got microbiome, had adapted to do that geographic location and those types of foods. And it was very adept at breaking them down, you know, creating energy from those. And, you know, we're such a no mad world. I mean, I did 14 cities in 18 days. Right. So, and I'm very intentional about what I eat, but I could control it to that extent. And so you're some padi and rhythms and all that stuff. Yeah. So you might have a microbiome driven. But if we could keep the consistency and they got microbiome, our ability to adapt to, you know, a different environment and actually metabolizing, you know, different types of food, you know, I think that to me is one of the secrets to longevity. But you're right, she had very specific strains that were in excess, especially for age. Yeah. And these were taken the studies were done about a year before she died or something like that. So near the end of life. Yeah. Right. Yeah. So near the end of life and still still crushing it. Yeah, still crushing it largely because I've ever got microbiome. Yeah. Let's let's go to, you know, a big fear that that grips a lot of people, which is Parkinson's Alzheimer's dementia. These neuroinflammatory conditions that cause different forms of cognitive decline. Right. They interrupt the communication of our, you know, in our brain so that we appear to be losing our memory or we get this oriented or we get confused. I mean, that's everybody's biggest fear. Yeah. And most of us have either had a friend or a family member and that we've seen this. And what could somebody do now to mitigate the risk of? Because you did talk early about Parkinson's. Yeah. For a lot of these neurodegenerative issues, there are changes in the gut that happened years before the symptoms develop. And one of the easiest things you can do is get your microbiome sequenced over time because it's a dynamic system like you talked about. Right. And you can monitor those changes and how they can determine if you're potentially going to develop Parkinson's or not, our ratios of separate type of two different or three or four different types of bacteria. Right. How is this ratio of this bacteria to that bacteria? You know, and how is that ratio changing over time? How does that increase your risk factor? Yeah. For these type of... Yeah. So at a minimum, if I knew that I either had a genetic predisposition, which they're not... Totally. They're not a genetic inheritance of the disease, but they're a genetic predisposition to the disease. So if I knew I was in that risk category, or I had cognitive decline, Parkinson's, Alzheimer's, they ran in my family. Yeah. What would you be doing right now? If you're listening to this podcast and that's one of your concerns, what would you be doing right now? You send the bacteria into your lab and start culturing the bacteria that combat those neuroinflammatory conditions. And we know what they are. And so at a minimum, this would be a good risk mitigation tool. Yeah, at least have an understanding of what's going on over time. Yeah. Right. A single test is going to be okay, but it's the over time testing that will determine a lot of risk factors. And then saving your original young bacteria right is really important. Yeah. Right. So as these ratios under your bacteria change and you get older, you can always go back to that young bacteria that we have in storage. So if you have 3040, if you're in your 30s, 40s or 50s, you have either have the genetic predisposition to one of these conditions, or it runs in your family, which is one of the things I don't like to. I don't like a lot of these familial characteristics in disease because it makes people feel like there's nothing I can do. Right. My Parkinson's runs in my family. I'm just going to get Parkinson's not true. Yeah. You know Alzheimer's runs in my family. I'm just predestined to get part of Alzheimer's test. That's why I like my product as a catalyst for change. Yeah. Like a user driving. Like people are aware of these things. Yeah. Right. And it's like, oh no, like with this product, I can start the change that can happen. So right now, I can send my stolen and saliva sample in. Yep. And I can, you know, look at my profile and I can at least begin to re-inoculate bacteria that are known to be the antithesis of those conditions. Correct. That can happen today. That's amazing. So in a perfect world, where do you see craft microbiome going? Where's craft microbiome going to be in five years based on what you're doing now? Well, next year, the dream is the application, like an app on your phone that you plug in that says, like, I have a meeting today. I want to run a mile. And, you know, I have a dinner tonight. And then you have a box next to it. And the app spits out, oh, take ProBag number one, three, and six. And you have the box of like all your different bacteria. Like take this one at this time, take that at that time, you know, to like show the, you know, I love that. Yeah. So that's the, that's next year. Yeah. Yeah. We do that now with, you know, certain, you know, just certain supplementation. Yeah. We take focus pills and, and no tropics and, you know, nicotine and caffeine. And, you know, so we, we do try to manipulate, you know, ourselves for certain activities. But the fact that we could do it with, you know, bacteria that produce neurotransmitters, like at one point, a customer wanted to get super, like he's like, I need something for golf. Right. And so I, I'm like, I don't know. There's somebody with no problems in their life, right? By the time that they're biggest concern is their golf game. I know. But I want to be that dude. Like, I mean, a lot of things would go on my list before I got to my golf swing. But so I'm like, I, I grew up, I played a little golf. I don't play that much now. I'm like, oh, so you need to be calm. You need to be relaxed. You need to do x, y, z. So I made these bacteria for dopamine for serotonin that produce this stuff. I give it to the guy, his golf game gets a little better. But what really changes it is it helps him sleep at night. Right. And so sometimes you make this concoction like you take this. And, but it doesn't do what you want. But then it has a benefit for something else. Yeah. Well, I mean, you know, that's why they've got microbiomes so fascinating. Yeah. We don't realize that, you know, just saying that all that produces neurotransmitters, yeah, but neurotransmitters are the foundation of mood. Yeah. They're the foundation of behavior. They're, they're, they're the foundation of our emotional state. Yeah. You know, and aberrations in those things get us diagnosed with mood disorders and mental illness. Yeah. When the truth is these are deficiencies that are expressing themselves as these conditions. And the next thing you know, you know, you're on an SSRI or, yeah, which causes all sorts of microbiome problems. Right. Which again, it's just fine. So the, the, the fact that we could get out of the chemical synthetic pharmaceutical realm and get into the bacterial realm. Yeah. Which is, you know, instead of saying, I, you know, have a mood disorder and hate these words, but mood disorder because I have a deficiency in the neurotransmitter serotonin. So I'm just going to take a selective serotonin, re-uptake inhibitor instead of doing that to say, I'm going to take the bacterial strain that give me the proper level of, of serotonin. So I can just have normal mood without intervention. Right. Like that to me is what's so fascinating about this. I mean like, I'm going to follow your work. I would love to select, you know, eight or ten of my, you know, VIP clients are from my VIP community and, and, and see what challenges they are currently facing. That we know map to the microbiome. What are the, what are the risks that they want to mitigate in the future? Maybe they have all summers of dementia or cognitive client and family. Maybe they haven't an autistic loved one, which we know, which is also being correlated. Yeah. There's two specific bacteria. Yeah. And there too. It correlated the inflammation in the gut. Interestingly, the FDA just approved philinic acid. Yeah. They just approved philinic acid, prescription strength philinic acid, which is essentially the methylated form of, of pholic acid or folate, as one of the frontline prescriptions that a physician could write for. Awesome. Neurodevelopmental disorders. Yeah. I know you're huge into that. I'm huge into that. And I was so excited to see that happen. It was like a eureka moment for me because finally, something that is not chemically or synthetically altering our natural biology to fix, you know, symptom. How to do with that. So, and, you know, finally, something that is not altering our physiology to get the result that we want, it's going back to our physiology. Yeah. And saying, could this deficiency cause this symptom? And instead of going after the symptom, let's go after the deficiency. And that's why I think that, you know, what everyone will call it, my work, my passion, which is restoring healthy physiology to get the outcomes that we want. You know, autism, I don't need to tell you about autism rates in the United States and the statistics are scary, you know, one in 5,000 to one in 32 children. And that is expected to double, double again in the next, in the next five years. I mean, the rate, the parabolic rate, which it's increasing. And yet we don't, we can't say this causes this. Vaccines cause autism. A sedumin if in during pregnancy causes autism. We haven't, we haven't reached that. We know that there's correlations. Yeah. The reason why I believe that these are correlated is because of their impact on the microbiome. I don't have the specific peer-reviewed randomized clinical trial to prove it. Yeah. But maybe you do. That would vindicate me. Well, it, um, it reminds me of a paper about super centarians and how the microbiome ages over time. And they tracked people, I forget how long, but at age groups, it was like something like 30,000 people they took samples from all different ages from 20 to 80. And they identified specific bacteria that decrease as you age. Right. And so that's part of the storage. That's one of the bacteria I slate is these young bacteria. But what also was found in the paper was the amount of oxygen tolerance in the gut goes down as you age. And what that means is the, um, the bacteria that, you know, they're not oxygen tolerant, but are, they're fed by the, the increase relative to, the, to the number of pharmaceuticals you're on. Right. And it, it, I mean, you are degrading the capacity for normal pathocacterial function, the more you, the more we absolutely knew that in the mortality. Yeah. The more pharmaceuticals you were on, the easier it was to predict your life Yeah. And it's, um, it's now, not a good way, but correlated or related directly related to your microbiome. And how much inflammation, how much oxygen tolerant you are inside the gut. Yeah. I think that's just, it's just so fascinating to me. And, and now that we are beginning to map, causal relationships between certain bacterial deficiencies and well-known disease processes. Not the least of which, you know, acromansia and cancer, for example, should wake everybody up to the absolute importance in the necessity for healthy microbiome. Yeah. And that, and that our modern day lifestyle, um, is the polar opposite of what we need to have a healthy gut microbiome. Yeah. Yeah. And, you know, I always talk about this theory. It talks about earlier in the podcast of the one domino that falls that causes all the other dominoes to fall. Yeah. And very often the first domino to fall is this got dysbiosis. Yeah. In fact, there are a lot of, you know, when, when pathogens invade us, bacteria, parasites, viruses, um, even, even heavy metals, and mold and microtoxin. Yeah. The vast majority of what they are impacting is the microbiome. And then the microbiome deficiency is giving us the symptom. Totally. Yeah. Okay. Right. Like oftentimes for myself, like, um, you know, before you get sick or have a cold or something, you'll have some diarrhea or something beforehand, like a few days beforehand. And that was found during COVID too. They could track, uh, Google searches on diarrhea before the COVID would show up in the sewage samples that they were testing. Yeah. So like a few days before, like searches for diarrhea, gut dysbiosis or whatever, with spike a few days before actually the, the virus would show up in the, in the sewage or before cases. Yeah. You know, interestingly, whoop noticed certain trends in their whoop data, which I found really fascinating, you know, like respiratory rates starting to increase substantially in the days before they became symptomatic. So they were infected. But while the viral load was rising before the patient even knew that they had it, um, they noticed this massive correlation between respiratory rates and the onset of COVID to the point where it actually became predictive. Yeah. Um, so, you know, but, but, but, but again, if you're listening to this podcast, um, you know, what should, if, if someone wants to take the next step, yeah, um, I feel like everyone could benefit. Yeah. From sending a stool or saliva sample into your lab, first of all, could you handle that kind of, and I can handle that volume now. You can now, okay? Recently, yes, I can handle the volume. Okay. So, so sending in a stool in this saliva sample, having their, um, microbiome sequenced and at least getting on a basic probiotic coming from their own flora. Yeah, starting with one or two. Starting with one or two. Yeah. Um, addressing the deficiencies in bacteria that we know have major impacts on mood, major impacts on emotion, major impacts on inflammation. Yeah. Um, so that you don't buy yourself a consequence down the road. And I, I like that idea better than, I mean, I know some phenomenal probiotic manufacturing companies. And, yeah. But again, this is the one's eyes fits all, but it's all we have right now. Yeah. Um, and I utilize them a lot. And there's some phenomenal products out there. There's like, like we were talking about before, like the World War One soldier and, yeah, yeah, there's tons of great companies. I really, well, I want some of his if you've got it lying around the lab. I want, I want some of his back. Okay. Yeah. I got an in guys. So, um, and then I'll, and then I'll start reselling it and maybe I'll, it's like, you should, yeah, we can sell Gary, Gary breakfast own. Yeah. But no, I, I think for the vast from Gary for the world, I like it. Yeah. Let's, uh, let's trademark that today. Uh, so I, I think that, you know, you send in a stool and it's a live sample. Mm-hmm. You get this profile, you culture those bacteria and you begin to re-annoculate. What is the worst thing that can happen? Your inflammation goes down, your mood improves. Mm-hmm. You see that your cognitive function begins to improve. That brain fog starts to lift. Yeah. And potentially you are mitigating the downstream risk of neurocognitive decline. Right. Um, which is, you know, what none of us want. I mean, this woman that passed away at 118 years old, I, I saw some of the, the interviews with her and fascinating to me how cognizant she was at 116 and 117 years old. Yeah. I mean, very, very, very good grasp of where she was, what was going on in the world, her environment, you know, she wasn't living in the past, she wasn't a loof, she wasn't despondent. And, you know, if, if the very things that create thought, neuro transmitters are made in the gut and that those are made in a factory that is run by bacteria. Yeah. There's a linear correlation between these. Yeah. Uh, so would you recommend that everyone at least start their stool and, yeah, just store it and get the test done. And then I begin to take your own probiotics. Yeah. Yeah. That's fascinating. Take your own. Um, one is, what is one question I haven't asked you that you think everyone needs to know about the gut microbiome and or could be solved by what you're doing in your lab today. I'm question you haven't asked. Um, I guess where I think it's all going. Yeah. Where's it all going? Where's it all going? Um, you and I talked a little bit about this the other day, but like the viral did we talked about this? Yeah. Um, and how there's a really crazy paper and bacteria have viruses just like humans have viruses, but these viruses only attack the bacteria. Um, and bacteria have viruses. Like bacteria carry viruses. No, no, like, um, there's a virus that will only go after lactobacillus. Oh, right. Yeah. And that's called like a phage. And so this crazy study, uh, bacteria infected by a phage makes mice and makes flies smarter, um, increases memory, increases, right? No one knows why this is the case, but in the flies, they have a longer memory and in the mice, they can solve the maze quicker. Okay. Right. Early, early stuff. But that's it. That's really interesting to me. Like why is, why is that happening? Yeah. Yeah. Um, I know it sounds a little scary, but yeah, those viruses have no effect on us. This, uh, they're only dangerous to the lactobacillus. But then the lactobacillus has an effect on us. Yeah. You know, and so again, we're getting back to that first domino that fell. Yeah. And um, soon, uh, it'll be possible to model, I'm getting two technical, like, yeah, technical for a second. Um, soon it'll be possible to model all the AI. Yeah. Yeah. Through all the metabolites produced, uh, by one bacteria eaten by another downstream effects, like be able to create a digital twin of all the bacteria and be able to model the food you eat and all the metabolites, you know, have a, this many grams of B vitamins or whatever are produced, you know, as, which I think will be really cool. I think that'll be really cool too. Yeah. Well, Anders, this is amazing. Um, I have a group of, uh, folks that community that I'm building called the VIP community. So when the podcast is over, we're going to go into this, uh, VIP community, because they're the community that I let know ahead of time who's coming on the podcast. Okay. And so they've looked into your background. They have a series of questions for you. If you're interested in becoming a VIP, just go over to the ultimate human, the ultimatehuman.com forward slash VIP. Sign up to be one of my VIPs. You can cancel at any time. I have a 10 month course on becoming the ultimate human in there. I do lots of live Q and A's and do private podcasts. Um, I've written, uh, guides on mold detoxification, heavy metal detoxification, whole food diet, travel tips, sleep, morning routines, even exercise. And there's just a amazing community of like-minded human beings in there. So head over to the ultimatehuman.com forward slash VIP and just sign up to be one of my VIPs. And I'll see you in there. But, um, I end all my podcasts by asking all my guests the same question. And there's no right or wrong answer to this question. Okay. And that is what does it mean to you to be an ultimate human? Uh, I'm still very athlete driven. Uh, I, I still want to compete at an elite level and as many different sports as I can. Mm hmm. What are you now? 38. Oh, you're not out. I'm an old man. Hey, dude, I mean, Tom Brady. You know, uh, uh, uh, Krishna Ronaldo. I mean, I was a lot of, uh, a week ago, I raised at the head of the Charles, the world's largest rowing regatta. Oh, you did? Yeah. Uh, right. I did pretty well. We got eighth at our category. Okay. Uh, and is it aged? I was in the alumni event. Okay. So former college and national team athletes. Yeah. And, um, but that's awesome. You know, I want to be able to do that every year. And I want to win that thing. Yeah. Every year. Yeah. Yeah. You know, like one of my favorite things, uh, is it sounds crazy, but just being able to like work out with my family and my, my sons and, um, my oldest son was over here and Dubai with me. Uh, and my, my, my rest of my family is very nice. Yeah. He's, he's, he calls great. And, um, but not just being in same industry together and building businesses together, but be, but to have a shared part of your lifestyle because he, you know, he's, uh, very athletic. So it was my, my other son. So we're both of my daughters and, but to be able to just, you know, he's 23 years old and to be able to just go and just rock a gym session with him, do a hits cardio workout. Like it's, I sat down last night. I was telling my friend Umar, uh, come on. I was like, this is the best that life gets. You know, like we had a, we had a great day with business meetings and then, you know, my son and I and a bunch of our buddies. We just went to the gym. We, we had a trainer run us through this, uh, crazy CrossFit style, you know, Wad workout. And then at the end, we did these 30-second interval sprints and just to be able to do that with him, I'm like, this is as good as life gets. And I want that for everybody because when you have your health and your pain free, yeah, and your mobile for as long as possible, as long as you, your relationships deep in, yeah, really is so true. Um, well, Anderson, thank you so much for coming on the ultimate human podcast. Thank you. Thank you. I'm Todd T in the, in the VIP group. And for the rest of you guys, until next time, that's just science.