#415: Bioregulator Questions Answered: Follow Up To Dr. Bill Lawrence Episode With Nat Niddam

Welcome to Longevity. I'm your host, Natalie Nidham. I'm a nutritionist, a human potential and epigenetic coach, and I created this podcast to bring you the latest ways to take control of your health and longevity. We cover it all from new technology and ancestral health practices to personalized interventions and a very special interest of mine, peptides and bioregulators. Enjoy the show. Hi, I'm Natalie Ndam, your host. Welcome back. This episode is driven entirely by your questions. After my conversation with Dr. Bill Lawrence, the response was massive. So I brought in my producer, Aaron Ryan, to help me unpack it all. We're clarifying questions about bioregulator digestion, organ versus system signaling, and the key differences between longer chain peptides and bioregulators, all in one audience powered Q&A. Next, I'm going to thank two sponsors that make this show possible and have special offers just for you. And then we're off. Here's an interesting idea. Most sleep problems aren't about being tired. They're about your brain never getting the signal that it's safe to power down. You can be physically exhausted, but if there's snoring, city noise, or random sounds pulling your brain back to alert mode, you end up half sleeping all night. And that's when mornings start to feel heavier than they really should. Oslo sleep buds have become part of how I close the day. I stream something calming, a meditation, an audiobook, white noise. And once I fall asleep, Oslo sensors detect that shift and transition me into built-in soundscapes that I get to choose, designed to support deeper, more stable sleep. This isn't sound blocking, it's sound engineering. Oslo combines neuroscience, biometric sleep detection, and ultra comfortable design created by former Bose engineers. They're tiny side sleeper approved, last all night, and were recognized by time as one of the best inventions of 2025. Create a true sleep environment wherever you are. All you have to do to get yours is go to oslosleep.com forward slash NAT. Make sure to use code NAT and get $75 off your Oslo Sleep Buds. Let's face it, you can't change your biology, but you can support it intelligently. A lot of products chase surface level results while ignoring what actually drives resilience underneath, communication. When signaling gets distorted by age, stress, or environment, repair becomes less coordinated. And this is important, and especially in skincare. Vitaly understands this. They first earned my trust years ago with pharmaceutical-grade copper peptides like GHK-CU, one of the most researched regenerative signaling molecules that we can get access to that actually naturally exists in your body. Now, Vitaly evolved that science by introducing exosomes, the body's native messengers. They use zero age exosomes, which means the signals driving repair are cleaner and more efficient. Paired with copper peptides, it's less about forcing change and more about supporting skin to do what it already knows how to do. If you think about longevity in terms of mitochondria, signaling, and long-term resilience, Vitaly is skincare built for your biology. All you have to do to get your hands on some is visit vitalyskincare.com and use code NAT20 for 20% off. Welcome back, everybody. We have a really special episode today. By we, I mean me and one of the magic team members that works behind the scenes to create this podcast and make it as amazing as it is. And not that I'm throwing myself flowers, I'm throwing her flowers because Erin Ryan is my producer and she was actually my first producer way back in the day. and then we, you know, we kind of went off in separate directions and then she came back to me, which was like the best day ever. Anyway, Erin Ryan is an exceptionally talented producer. She has deep knowledge actually in the health space and she's been at this for a really long time, worked on one of the biggest shows in the business. But the important part is she came back to me and which I was so excited. So we once did what was supposed to be a solo episode as a, right? Way back in the day. So first of all, welcome Erin and thank you for agreeing to do this. Of course. Now you can hear her voice and she has a perfect voice for this. So it's amazing. So we did this way back in the day when she was first my producer. And basically, instead of having me just chat about this topic by myself, we've had Erin throw questions at me and it worked really, really well. And so for today's topic, we thought that format would really be much better for you guys as well. So basically we, I released a podcast with Dr. Bill Lawrence about bioregulators. When was it Erin? Back in December, right? Yes. Yeah. It was before Christmas. Yeah. And on YouTube, which is not my main channel, like folks, I think it's probably at almost 200,000 downloads, which may not be big by big people standards, but by my people standards, that's a lot. And the comments are still coming in fast and furious. So we decided let's go through the comments. There were tons and tons of questions, questions that seemed to be asked over and over again. And I thought, you know, I don't, you know, Bill Lawrence is a tough guy to get. So what I would do is give you some answers as best as I can. So the first thing I want to say is one of the themes in the comments, obviously, because in both Dr. Bill Lawrence's research studies, as well as Professor Cavinson's studies, some of these results are really jaw-dropping, right? And so very often we get people going, come on. I mean, if this was really a thing, surely my doctor would know about it, or surely it would be a bigger deal in North America, right? And skepticism is a good thing, but I can tell you, in my world, we have over three decades of research here. So I feel comfortable. I've also witnessed in my membership community and working with clients. And now with Dr. Bill Lawrence's work and other doctors now, lots of doctors in the functional medicine space are bringing the bioregulators in as a tool. The other thing that Aaron wanted me to say, and I'm now dominating the conversation, you guys. So at some point, I'm going to stop talking and let Aaron talk. But I just wanted to position the episode a little bit. This is obviously for education purposes only. We're not giving medical advice. And bioregulators are what I would refer to as your best tool in your tool belt. They can work on their own to a degree, but they also work really well with almost everything else. And we'll talk a little bit about, and maybe Erin, you'll fire me a couple of questions about that, like around safety, around how they really work. because it is the hallmark of why I think so many physicians, practitioners in the functional space are learning about them and weaving them into their protocols. So Erin, I'm going to let you fire a couple of questions at me now, because otherwise I'm just going to keep going and you're just going to be the pretty face on video. No, sure. Yeah, that sounds good. So what I did was I took many, many of the comments, like she said, there's still comments rolling in. I think there's a few hundred at this point. So we didn't want to sit there and answer a few hundred. So with the help of AI, we threw many of the questions into AI and got some of the themes. So your questions may not be your question word for word, but these themes will certainly answer many of your questions. And Nat will mention it towards the end, but there were so many and so many different themes of questions that we may even do a part two if you seem to like this episode. So holler at Nat, give us some feedback because there are some really, you know, deep dive topics into more serious questions that people had about health that we may be able to touch on just a little bit. So what I, the first theme that I was seeing with audience confusion was the difference between synthetic peptides and natural bioregulators. So this is something that so many of you ask about. And even, you know, we have a partner called Nature's Marbles and they are through Profound Health. And even on that site, you can find either a natural or a synthetic bioregulator. So Matt, can you help clear that up? What's the difference between synthetic peptides and natural bioregulators? Natural bioregulators are an extract from actual tissue gland organs of animals. So it is an animal product. It's very refined. There's no animal protein left. A lot of the bioregulators are derived from pork, from porcine. If you're allergic to pork, which pork is, if there's a meat that's allergenic, I think pork is one of the top ones. You wouldn't have an allergic reaction to it. So none of the protein from the pork is left in there. Now for, there's definitely groups of people in the world that won't touch pork for a number of other reasons. So that's a different story. But regardless, whether it's derived from porcine, bovine, or even from sheep, there are some bioregulators derived from sheep. There's none of the animal protein left. All that's in that capsule are the short chain. So the two to four amino acid bioregulator chain, but also there are supporting actors around it. So you have single amino acids, You've got other small proteins. So it's more refined, if you will, than a glandular. So you're not getting all the stuff that you get in the glandular. Like for example, in a thyroid glandular, you would get T3, T4, you'd get all kinds of other actives in there. So you're not getting the actives, but you are getting all of those signaling molecules that are going to enable the regeneration of the tissue or gland at an epigenetic level. Um, the synthetic. So when we talk synthetics, I'm going to distinguish between the long chain peptides and the bioregulator synthetic. So the bioregulator synthetic is when, and this is of the 21 bioregulators, all but five are available as a synthetic form. And this is where scientists have identified the main amino acid chain. So with epitilon, I think it's AEDG. Those are the initials of the amino acids that are in that chain. And they're able to synthesize it in a lab in the exact configuration that it occurs in nature. So it's bioidentical in the sense that it looks exactly like the one you'd get from the animal, but it's been synthesized in a lab. The longer chain peptides, and this is like the BPC-157, thymusin alpha-1, thymusin beta-4, all of those peptides, those also are bioidentical to what might be naturally occurring in our bodies, but they are not bioregulators because by definition, and maybe I'll talk quickly, that the longer chain peptides and even short chain peptides like GHK and KPV, they act as signaling molecules. So they bind to receptors and initiate cellular like cascades. The bioregulators, what makes a bioregulator a bioregulator is that it is an epigenetic switch. So that means it acts directly on genetic material in the nucleus of the cell, in the target tissue or gland or organ where it creates its effect. Okay. Is there a way to, so for someone who wants to avoid pork, do people typically include that detail with their bioregulators or do you have to ask? Yeah, you have to ask. You have to ask. But having said that, there aren't many suppliers of this stuff. Like the, the Cavinson's, um, I don't know if you want to call it methodology for extracting bioregulators is fairly close guarded information. So there to, to my knowledge, there's really, there's really for sure one, maybe two companies who actually will take the animal product and, and create the bioregulator, um, actual product that is then encapsulated or used however it's used by the manufacturers. So profound health that you mentioned, but make the nature's marvels that are natural bioregulators as per Cavinson's recipes. Like they have, they had a very close relationship with professor Cavinson right up until he passed away and had his blessing because what happened was it became impossible to get product out of Russia. And so at that point he kind of gave them the nod and they made their own. I got you. Okay. And our bioregulators, just to clarify, are they actually found in the human bodies or are we mimicking something from the human body just because it comes from animals? Obviously we're not going to take it from humans for ethical purposes. That would be a bad idea. Yeah. But the short answer is yes. It's like so many other things in our body. We just make more of them and we're more efficient with them when we're younger. So what we're doing when we're using a bioregulator later in life, if you will, is we're basically shoring up our defenses, right? We're now reintroducing them as a therapeutic agent. So we still have some, we just don't have as much. For the person that is super new into all of this, everything you said made sense to me for the most part, because I heard about this stuff a lot Is there a quick way to say the difference between the two between synthetic or is it just like you got to Yeah no actually you know there a bit of a difference in how they work, right? So typically the natural bioregulator, it will take a little bit more time to take effect, but the effects might last longer. And the reason for that might be because there's all the other players around it, because it comes with a cohort, it might be a more, If you want, it's like a deeper rebuild. Okay. Right? Instead of just changing the sink in the bathroom, you might actually do more remodeling. You might be like, oh, you know, the cabinet's getting a little soggy. Maybe we need to do a little repair work down there. With the synthetic, it's going to go in and just pull the sink out and plop in a new one. So that doesn't mean it's bad. It's quicker acting, but the repair might not last quite as long. Because it doesn't have all the signaling. Yeah, exactly. Now, you know, there was another interesting question about, you know, is one more like, will they work differently for people who are very sensitive, let's say. And interestingly enough, in Russia, they will sometimes start with a synthetic bioregulator because it's a bit of a cleaner hit. Okay. It's not doing as much. Yeah. Right. And they can also titrate it a little easier. The problem with the synthetics, I don't, I mean, Profound Health has a couple of synthetics. There's a couple of other companies that have more and we'll have links in the show notes, you guys, about where you can buy this stuff. Cause I know that was one of the big questions in the, in the Bill Lawrence episode is where do I get it? I've since added links to those show notes, but we'll add those links in the, in the show notes here. So people will have an option, the option to go out and source these things for themselves. Okay. Sounds good. I think we can move to another grouping of questions, which is the audience confusion here was more around if these are proteins per se, and I think you cleared some of that up earlier, wouldn't they just get digested? How does it actually make it through your digestive system without being destroyed or being absorbed some other way? There was many questions under that. That's kind of just the theme. Yeah. That's a great, it's actually a very valid question, right? We are led to believe that we eat protein and we have proteases and other enzymes that just chop up the proteins into, we believe, single amino acids so that they can be absorbed. Actually, not that simple. The body is more complex than that and there's more nuance. And when it comes even to certain other proteins, but definitely with the bioregulators, they're embedded and they are naturally occurring in food, right? Like if you eat liver, you're going to get liver bioregulator with your liver. You're not going to get as much as you it in a supplement, but you are going to get liver bioregulator. The way that mama nature decided to figure this out is she, the way proteins are digested is there are specific cleaving sites on either end of that amino acid chain. And so the proteases will go after those sites and you will now have just that bioregulator. And wildly, there are transporters for these tiny proteins across the gut lumen. And they'll get transported into the bloodstream and then they get delivered to their targets. So they don't break down the way we get broken down. So we don't need like a time release capsule. We don't need any, any fancy stuff. Like this is, you know, this is what makes them so powerful. Like this is a natural, this is very natural to the body. The body recognizes it. This is something it's accustomed to. It knows what to do with it. It knows what to do with it. We have all the machinery to use it, if you will. What we're doing is we're simply bringing it back in a more therapeutic dose. There was a question of what makes short peptides different. And I think that fell under the same kind of questioning as digestion. So you might have just hit that. But if there's something more to add to it. If the person means short peptides as in bioregulator peptides versus, let's say, the signaling peptides that we talked about, like the BPC-157. And some of those, again, like I'll say, KPV and GHKCU are three amino acids. You could say, well, aren't they bioregulators? What really sets them apart is that the bioregulator gets into the nucleus of the cell and acts directly on DNA. Bill Lawrence describes it as it repairs the DNA's ability to produce the proteins it used to before. Oh, that's a big difference then. Right? Whereas GHK, as much as it impacts like thousands of genes, right? It resets genes to a more youthful setting, but it does that as a signaling molecule. It doesn't actually get to the DNA. At least nothing I've read would imply that. KPV also, it's a very powerful anti-inflammatory. It has some antimicrobial benefits. It's really good for the gut, but it also, it doesn't do it through an epigenetic effect. It does it as a cell signaling effect. Okay. Yeah. That seems like a pretty good distinction. That was worth answering for sure. Do they survive stomach acid? It sounds like you're saying yes, and that we don't have to worry about that necessarily. You don't need to worry about it. It has nothing to do with anything. Okay. Okay. Another question was, are the capsules specially designed or should they be? Sounds like no, because again, the body knows, it recognizes what it is, knows what to do with it, knows where to send it. Yeah. We want it delivered into the gut. Like basically we want it delivered into the gut and that's, and it gets absorbed out of the stomach, out of the lumen. Can I ask a curiosity question? That's not. Yes, of course. That's the beauty of having you here. Yes. With this, other people may wonder this too. This is more about, I guess peptides than quote unquote bioregulators. We're seeing more oral versions of peptides. Should we still be like, for instance, BPC 157 is available a few places orally. But if we start seeing that like for $12 on Amazon, should we be concerned? Because I'm just worried that everyone's going to start creating oral peptides that, and I tend to only, I mean, I don't know if you care if I talk about brands, but obviously like through, through you, I've learned about level up. And so I tend to just stick with, with their oral peptides, but I have been wondering, cause I'm seeing them start to pop up different places. Yeah, no, those are really good questions. So number one, let's just agree that buying supplements in general from Amazon is, is problematic. Don't do it. It's just a bad idea. Right. And not the, the challenge is it's because it's almost impossible to distinguish the real stuff from the fake stuff. I, if I was a brand and I get brands are trying to survive. They're trying to make money. They're trying to, you know, like it's so funny yesterday. I came across a thread somewhere because good culture got bought by, um, like an, an investment company and people were railing against it. They were so angry and I get it. Like Ciate got bought and their quality went up in smoke. The, what I think what people don't realize they attributed to greed. I think what people often don't understand is when you get to a certain point of scaling. Sometimes these companies, they're a victim of their own success. They can't raise the money fast enough privately to survive. And so then it's a private equity firm. So then they get kind of thrown into this impossible situation. Like, do we contract? Do we close the doors? Do we go bankrupt? Or do we make a deal with the devil? Yeah. And unfortunately, if they're with any luck, good culture was able to protect their their quality somehow from the private equity firm. But I, you know, I feel bad because people are so disappointed. They're so sad. But I also feel bad for the founders because they're really just trying to survive. Yeah. Anyway, so I've completely digressed here. It's a good thing for people to recognize that even if you see a different seller selling your favorite supplement on Amazon, you may want to be a little... I mean, I'm not trying to get you in trouble with Amazon here. No, no, no. I don't do anything with Amazon anyway. But we just are saying that obviously if it's a different seller than the product that you're buying, that's a little... Maybe odd and maybe don't purchase that. Well, if it's too cheap, guys, generally speaking, there's a reason, right? I had this conversation with Karan Krishnan about ashwagandha, right? If you're buying ashwagandha for $12 or $15, not only are you not getting what you need, you could be getting bioactives that are harmful to your liver. This is why ashwagandha has a really bad rap. So number one, buyer beware. Now to go back to the actual question, which is about survivability of peptides in the gut, when it comes to the longer chain peptides, there is a race on to make these peptides absorbable through the gut. Because of course, the injectables are a problem on a million different levels. The BPC-157 is the exception to the rule though, as is KPV, as is lorazotide, and as there's some good evidence around GHK as well. And in the case of BPC-157, it technically makes no sense because this is a 15 amino acid chain peptide. So technically, it's a prime candidate to get chopped up into bits in the gut, but it comes from the gut. It is known to the gut. It has special status in the gut. So I need this myth to die right here, right now. BPC-157 can be taken orally. It is really good for gut health. It even sometimes in some cases can be helpful for musculoskeletal issues. Now, if you have an acute musculoskeletal injury, not going to lie, there's better, other, more efficient ways to use it, which at this stage of the game are not actually really allowed, but oral can work. I've seen it work. I've seen it work in people who were taking it for the gut and they had no idea, but then they come back to you two, three, four weeks later go, is it possible that my back pain is better? Is it possible that my knee pain is better? That's the only reason I take it. I didn't even take it for the gut and I was too scared to eject myself. So I was like, I guess I'll just blow a hundred dollars and see if this works. And now I've got like my mom on it. My dad has rheumatoid arthritis. He's on it. They're giving my 92 year old grandma that she can barely swallow pills, but they're giving that to her as well. And I can attest that I take it just so I can feel 27, even though I'm not 27. You look 27. Thank you. But aside from this, I'm a professional dancer and it's painful at my age to dance. But the months that I'm on the BPC, I feel unstoppable. So I'm sold and no one, it was just a test just to see. I'm like, I don't know, but I usually have a lot of hip pain, a lot of shoulder pain. And I feel great. As soon as it wanes, though, I'm back in my, you know, at the masseuse with those same issues. But I don't want to take it nonstop because I read that I'm not supposed to. So anyway, we digress. But I do think people are maybe curious about, okay, well, why are all the bioregulators oral and not, I'm not seeing all the, you know, all the peptides, the longer chain peptides oral. The next segment or theme of questions is going to be different from what we just discussed. Some people are struggling to understand whether it's organ versus system signaling. So now we're kind of switching gears to understanding how it works in the body and we're past the how does it get absorbed? And is this the same as food? So that's a really good question. And they are typically organ. My line is organ tissue or gland, right? So if you look at the names of the bioregulators or what they address, we have the pineal gland bioregulator, adrenal gland, thyroid gland, blood vessel, heart, liver, lungs, bone marrow, central nervous system. So the short answer is it a little bit depends, right? Because it's going to target the pineal gland, but the pineal gland is going to affect systems. It's going to affect the endocrine system. It's going to normalize melatonin production. It's going to help to reset circadian rhythm. The blood vessel bioregulator is going to affect the entire circulatory system, right? It helps to restore integrity and function to the lining of the blood vessels. There was another bone marrow bioregulator. is going to address bone marrow. So, um, cartilax or the cartilage bioregulator. Okay. You're going to be like, Oh, that's joints. No, it's, you have cartilage in your skin. You have cartilage in your blood vessels. You have cartilage in every organ that has to expand and contract, which is pretty much all of you, even in your bones. So, so in the, in the case of the cartilage bioregulator, which upregulates the production of collagen and elastin, you're affecting the system of collagen that is through the body, right? But when it comes to the adrenal bioregulator, it's going to affect the adrenal glands specifically or the thyroid, right? So it just depends which bioregulator and from a downstream effect, it ends up, of course, impacting what all the systems impacted by that gland or that tissue or that organ, Right. So kidneys might be helpful in detoxification, obviously, but kidneys could also might be helpful with blood pressure regulation. So the next question would be, how do they know where to go? But can I take a stab at it from what you just said as a learner as a listener and learner So if you said that the body knows what to do with it and it also derived specifically from some organ or gland of an animal, that the body, it already has messages or it comes with a set of messages. It's going home. This is the wisdom of the human body, right? I'm sure somebody smarter than me would have a much better answer and I could probably go dig it up and maybe I'll talk about it next time. But at the end of the day, it's this whole, there's so much powerful messaging at a cellular level that happens in the human body that you can almost imagine it as a homing signal. It's packaged with instructions as it enters. And they're much better than IKEA instructions, I'm sure, because they seem to know where to go where I never frigging know where to at anything. They forgot to drill the one hole, the final hole, the piece together at the end. Yeah. So better than that. Can they affect multiple systems at once? Yeah. I thought, yeah, they can. And like I said before, right. It's because as a downstream effect. Yeah. And the pineal gland bioregulator in particular, it affects almost everything. It affects the immune system. It affects so many different systems. What about the thymus one that you And the thymus gland bioregulator affects the immune system. And the immune system is going to fundamentally... Yeah, everything. Yeah. Okay. That's an easy one. What's the hierarchy? I don't know how you're going to answer this question, but good luck. What's the hierarchy? Brain versus immune versus endocrine. So I guess if someone's choosing just to get started with bioregulators, do you go, what am I having trouble with? Should I start there or I'm aging, where do I start? I guess it's, people would be in different categories of starting bioregulators for different reasons. So what would you say to that? Yeah, I would say, look, if you look at Cavinson's work, if you gave him one bioregulator to play with, it would be the pineal gland bioregulator. Yeah. Right. And the pineal gland bioregulator will impact immunity, endocrine function, circadian rhythm, and telomerase, telomere. so he's touching all four of those right there yeah if you gave him a second bioregulator when he did his elderly people studies that's when he brought in the thymus gland bioregulator this is the emphasis got put on the immune system and so to me right you have to start with the immune system and and certainly and you and i'll do another podcast together maybe about my journey over the last couple of months. And I knew this before, but this experience has cemented for me that proper immune function is the key. And I don't care what anybody says, is the key to healthy aging. Because if your immune system is not working properly, it's going to affect your cognitive function. It's going to affect your cardiovascular system. It's going to affect your joints. It's going to affect your ability to modulate your response to any number of things. It's going to impact inflammation. What's one of the hallmarks of aging? Yeah. Inflammation. Right? So inflammation is a new hallmark of aging. So it's going to impact your microbiome. It's going to, now your microbiome is also going to impact your immune system. But to me, it's going to be, it would be pineal gland, not because brain. Yeah. I mean, look, if you're having issues cognitively, you're going to want to bring in the blood vessel bioregulator. You're going to want to bring in the central nervous system one and the pineal gland, but you have to modulate that immune system. Yeah. It sounds like most people would be would be good to begin with pineal gland, thymus gland, bioregulators, and then follow that with whatever, say you have heart health issues in your family that you're trying to avoid, then maybe you're looking at the different vascular. I would say the blood vessel would be your number three. So if you had a triad, right, I will often talk about this when I'm speaking, is your first triad would be your pineal gland, blood vessel, and thymus. Those three would be the core. And I think if we added two more to that, we would add the central nervous system and cartilage, interestingly enough. There are some good tools in longevity that are powerful, but quite impractical for daily life. Ozone therapy is one of these. The research is compelling, but most people aren't going to clinics multiple times a week or setting up equipment at home. And honestly, you shouldn't need to. That's why I was so curious when Wizard Sciences launched Oracle. It's their first ozonated oil in a capsule designed to be used daily. No machines, no appointments, just a simple addition to a routine that's already working. What makes it so interesting is its delivery. Oracle uses an acid protected capsule. So the ozonated oil reaches the small intestine intact. That matters because ozone doesn't work like a typical antioxidant. It acts as a signal, encouraging your body to increase its own antioxidant production, support immune balance, and improve cellular communication. And because it's delivered through the gut, you're supporting the system where immunity, detoxification and energy regulation all begin. If you're looking for a smarter, more practical way to support resilience at the cellular level, you can learn more about Oracle at wizardsciences.com and make sure to use code NAT15 for 15% off your purchase. What if someone finds that they have a tough time with methylation? Would the liver one be a good one? Liver is great for liver support. I don't think it'll, you know, one thing to remember with the bioregulators is you still need to do everything else. Right, right. If you need methylation support, you're still going to need to properly supplement the things that you need for methylation support. Think of the bioregulator as the work crew that's coming in and doing the big work. they still need everything else to be in place. They need materials. They need tools. They need, you know, they need all the, all the things to create what you're asking them to create, but they are the experts in the house. Yeah. And then some of the other ones that are kind of cool, but it seems like you could still say, start with pineal gland and thymus gland bioregulators are like some of the ones that you've talked about before that like help with gum regeneration in your mouth. And isn't there like one for eyes as well for retinamolone? Yeah. So there's an eye, there's a bioregular for the eye, but the, you know, if I'm working on the eye, I'm also thinking about my blood flow to the eye. Oh yeah. Interesting. Blood flow comes into play everywhere. Yeah. Right. And the bone marrow bioregulator is another one that has to kind of, you have to keep bringing it in because rejuvenating your bone marrow, that's where your immune system comes out right? That's where like your bone marrow is super important. That's where your cells are coming from. That's where your regenerative, your physical regenerative properties are coming from. You know that better than ever now. Oh yeah. First hand. So that's, that's actually all a good segue to the next set of questions, which is around how should I take bioregulators? So some of this we've kind of, we've kind of answered globally, globally, but some of the more specific questions are, are they taken daily? Are they cycled? So when you're using a bioregulator, you're taking it every day, but they are cycled. Now, how long they get cycled for depends. So from a preventative perspective, let's say you're doing, you want to use the pineal gland, thymus gland, and blood vessel. You want to use this because you're feeling like your body could use a little refresh, right? So we're using these as a healthy aging strategy, let's say. So we might, depending on our age, we might do that cycle. We might do 30 days, once, twice, three times a year. So if I have someone in front of me who's in their forties, I might say, well, you know, once or twice a year, you can do a 30 day run. If I have someone in front of me and in their fifties, depending on their state of health, We might say two, maybe three times a year. Once we're hitting our 60s and 70s, I would say, you know, three to four times a year wouldn't be the worst thing. Yeah. So that's more preventative. What about therapeutic? So therapeutically, what we will typically do is if we're trying to support improving function in a system, so we're now using them as part of a whole plan, let's say. what I would typically encourage people to consider is a 30 day run to kind of, and if we don't see much after 30 days, we might repeat the 30 days, right? But if we've, after 30 days, we start to see the needle moving on things. And now hopefully we're measuring labs. I've seen it help with thyroid. I've seen it help with adrenals. I've seen it help with a lot of different things. If we're not going to repeat the 30 days, what I often encourage people to do is to do 10 days a month for another two to three months, just to kind of remind and refresh the signal. That would be therapeutic. Like you feel like you've, your immune system really took a hit. You're trying to beef it back up. Yeah. That kind of thing. Okay. Yeah. I have heard of the 10 days and I didn't know who that was for. The other time I use the 10 day cycles is in a, um, kind of like a, um, a healthy aging strategy. And so when I, you know, in my membership community, sometimes will do a year of, I'll offer a year of bioregulators programs and people will pay a bit of a bit more and I'll sit down and write out a protocol for them for a full year. And what I'll do in that protocol is number one, I'll take into account some of the propensities they might have. So like say someone like me has a propensity to have, um, to develop tight tube diabetes. As I, as we get older, I have certain genetic dispositions runs like wildfire through my family, the whole nine yards. So I might spend a little bit more, I might put a little more emphasis a little more often on the pancreas and the liver, stuff like that. But typically what I like to do is I like to start people with that 30 day run of almost all the bioregulators. And then we fall into 10 day cycles per month and we cycle through the bioregulators. We just might come back to certain ones that are of particular areas of particular focus for an individual. Do healthy people benefit? Well, you've already answered that question. Yes, because preventative is... So I'll give you the analogy that I always use on podcasts. And that is that the way I look at bioregulators is the way I look at how the tires on my car wear. When you first get your brand new car tires, if you've ever looked at your tires, they're kind of fuzzy. They've got the little fuzzy things on them. The tread is super deep and they're fresh and they're amazing. And as you drive on them, the little fuzzy stuff wears off, the tread starts to wear down. In a healthy person, we're not waiting until the tread is gone. We're just, our tires are still gripping. We're still good, but we're losing tread. So what we're trying to do is rebuild resilience into that tread before we lose function. One thing that's really important to know about the bioregulators is their job is to get you back into balance. they are not going to make you super collagen producer. They're not going to push your thyroid into overdrive. They're not going to give you super physiological dose levels of melatonin. Their job is to get those levels back to where they need to be. And this is why in elderly people, you often see the pineal gland bioregulator really show up, right? Because their melatonin production is in the toilet. And now you start to restore their melatonin production and restore their circadian rhythm, assuming that you can get your mother from doom scrolling till one o'clock in the morning on Instagram. Sorry, I'm throwing you under the bus there. But as long as you don't fight it and you go with it, elderly people often experience very profound shifts because they're the ones that are way off baseline. Yeah. So you just answered this question. There was another question of are they age dependent? And that's, I mean, basically what you. Yeah. I mean, definitely there's use case scenarios, even in, I've seen them used in quite young people and kids when there's imbalance, there's no reason to use them in a young person. Right. But, you know, by your late thirties, things are starting to, you know, sadly folks, that decline starts to happen around the age of 30. Some people say even younger, but I would say I'm around age 30. And at age 30, like I wouldn't be pounding the bioregulators if you're a 30 year old, but definitely by the time you're hitting 40, you might want to, it might be time to think about, okay, well maybe I'll at least do some of the basics. You can start to feel the tires wearing at that point when you're around 40, I think. Okay. So the next section is, we're kind of going back to the digestive conversation, but there was more specific questions around food. Like could someone, instead of taking bioregulators, can't I just get it from food if I eat nose to tail? Or if I tend to eat a lot of organ type meats, am I good? Am I getting all the bioregulators? And if not, why, what's the incentive of taking bioregulators on top of that? Okay So let me start by saying food should be at the foundation of your healthy of your health Right And if you eating organ meats that is amazing And you will get bioregulators from the organ meats Here's the tricky bit. Number one, I don't know the last time somebody told me that they were eating kidney, thymus, adrenal, thyroid, blood vessels. Number one. Number two, you're not getting a lot, right? So it's a good idea, right? And so there's a hierarchy, if you will, of sourcing of bioregulators I refer to. So number one is the organ meats and food in general. So you're going to get a sprinkling of it through those foods. Your next layer is going to be organ supplements. So things like heart and soil, ancestral supplements, paleo valley, these are all companies that have in their lineup of supplements, desiccated organs that they've encapsulate it. And very often you're going to go to their websites and you're going to see testimonials waxing poetic about an impact that someone experienced from using some of these desiccated supplements. And part of that is simply because not only is there bioregulator in there, but there's all the other stuff. Think about liver. Liver is nature's multivitamin. You're getting methylated Bs. You're getting bioavailable vitamin A. You're getting vitamin D. You're getting all this amazing nutrition as it's encoded by nature. So it's bio-identical. Your body knows exactly what to do with it. So I think those organ supplements, especially for most people who won't eat organs, are great on a day-to-day basis. Or you get products like Pluck, right? So Pluck was created by a chef, a Hollywood chef, and he decided everybody needs more organs in their life. And so he's created these spice blends with organs in them. Like brilliant idea. You're not getting a lot, but you know what? You're getting more than you would otherwise. Right. That's so interesting. And then I remember. Yeah. And then the next level up from that would be your glandulars, which have been a part of alternative medicine forever. The thing with glandulars is they're, they're very, very active. You need to know what you're doing with them. Right. And so the, the example that I always give is like the thyroid gland glandular. You really will never use that for someone who has an under, has an overactive thyroid because you'll send them to the moon. Whereas our next layer up is the bioregulator. Now the thyroid bioregulator, you can use for someone who either has an overactive or underactive thyroid. Okay. Because it's looking to come back to homeostasis. So that's kind of like your hierarchy. So what's So the short answer is when we're looking, it's the reason why we take supplements, right? Like you can get taurine from food. The reason we use taurine as a supplement is because we need a therapeutic dose to correct an imbalance. Same thing with the bioregulator. Okay. So would someone who eats organ meats also want to supplement with that or it's kind of a either or? I'm sorry, supplement with the organ capsule type things. Look, if you're Paul Saladino and you're popping raw liver every single day, you don't, right? For most people, if they eat liver once or twice a week, it's a lot. And it's probably enough at that level. You're just not going to get the therapeutic effect. You're not going to find pineal gland to chomp on. You're just not going to get a bag of pineal glands you can munch on during the day. It's not going to happen. I could see that. If the organ meats are cooked to death, does that destroy the bioregulators? I mean, we don't want to encourage people to be eating like raw liver unless you know how to deal with it. I know like Ben Greenfield eats raw liver in his smoothie, but he also like puts it in buttermilk for a time. He does some things to it to make it safe to eat. So, you know, that's not the recommendation here necessarily, but does cooking it, do you miss out on the bioregulators or? Yeah, it's a good question. I don't fully know the answer to the question. I don't think you do. Honestly, I don't, I think they're pretty hard to destroy. I think you'll lose enzymes. You're, you're going to lose other nutrients. And that's why people think raw liver is better. If you can make it safe is that, you know, you've get all the enzymes already naturally present in the food and it's unadulterated, but you know, it's like eggs, like raw eggs. There's, you know, there's a legion of bodybuilders out there that swear by raw eggs. The tricky thing about raw eggs is raw egg white actually robs your body of biotin. Right. People don't realize that. So raw egg yolk bomb is the best because you're getting the choline. You're getting all egg yolk is better when it's uncooked. Egg white is better when it's cooked. Like, you know, so it's going to depend. I just think with the bioregulators, my sense is they probably don't get destroyed, but you are going to lose other things if they're overcooked. okay and this next question i like the way they ask this question is this filling a modern gap and i think you just said that in so many ways i mean i think all of us ate or our ancestors ate more yeah organ meat than ever but we would need it first right i mean if you go if you go to hunter-gatherer hunter-gatherer groups they eat the organs and they hear i mean if you go to the animal kingdom, they go for the organs first. Right. Oh yeah. That's interesting. They get all the nutrients first. Yeah. Yeah. Okay. Well, that was super interesting. So I guess the last grouping of questions we'll look at, does this actually move the needle? So people want to know about evidence, clinical outcomes, that kind of thing. Bill Lawrence talked a lot about that in the episode. So you can kind of go back and read that, but there were still some lingering questions, some of which were, is there evidence bioregulators can help specific conditions? So if you want to... Yeah, there's, I mean, look, there's number one, there's definitely lots and lots of research around this. Definitely some of the books that have been written about the bioregulators talk about specific use case scenarios. I've seen studies where they did, there was one on COPD, I think, where in one instance, people were given just the conventional medication. And the second group, the test sub, so the control group just got the conventional meds and the test group got conventional meds with the bioregulators and the conventional group did, they got the effect they were supposed to get from the drug, but test subjects who got the bioregulators had better, faster outcomes. And in some cases either used less or no medication depending on the person. So that's what I was saying earlier. Like they play really well with other interventions. So they are not medicine, right? So sometimes you need medicine, but sometimes what if you could take medicine and encourage the body to repair at the same time? Yeah. The other question is what biomarkers improve. And I think if you're someone who's looking to improve certain biomarkers of your own, like go out and look for that specific research, because it seems like there's decades of research to look at at this point. Yeah. And what I've seen them do is in people with liver issues, I've seen liver enzymes improve over time, but that's not the only thing people are doing. Right. Like I had a woman who had Hashimoto's problem and she'd been going at it with her naturopath forever. She finally decided to throw the bioregulator in there. So she had changed her diet. She was supplementing, she was doing all the things. And finally, when she threw that bioregulator in, that was the final piece of the puzzle that clicked for them. So it doesn't mean you can, if you have Hashimoto's, you can run out and take a bunch of thyroid bioregulator and your Hashimoto's is going to go away, but it can be helpful. It can support all the other things you're doing. And sometimes, and you'll see it, obviously you'll see it reflected in your blood work. Yeah. Who sees the biggest impact from bioregulators? That's a pretty generic question because we've talked about a lot of different examples of that. I think that the people who see the biggest impact are going to be the people who are doing everything else, who are also supporting the system in all the ways. Definitely we see in some of Kevinson's work, like elderly people really, like the old people study where he gave them the pineal gland bioregulator, like every metric got better. Like their quality of life got better. Their sleep got better. Well, and when your sleep gets better, everything else gets better, right? Their bone health got better. Their immune health got better. Like everything, they just became more resilient people. Now, is it because they were sleeping better? Is it because they were making melatonin? Is it because their telomerase was activated and their telomeres? Is it the global impact of all of those shifts? Probably. But so sometimes you're going to see it more. I said this earlier, sometimes in elderly people, they'll feel it a little bit more or someone who has an imbalance, anybody will feel it more. Somebody who's doing it preventatively might not feel much at all. So then it becomes a bit of a leap of faith. So then it becomes, not so much a leap of faith, but then you really truly have to believe that this strategy is going to be helpful to you because you're not necessarily going to feel it. Now, if you're someone who does labs fairly regularly, you might see really subtle shifts in the right direction, but that's going to be, that's going to be based on the individual. I mean, if you're drinking a bottle of wine every night, you might not see much at all. Yeah. I mean, it also probably, I mean, I hate to say this, but separates people from one person getting some kind of, I don't know, like some virus or something like that. And one, one person really being dragged down by it. And then the same age person doing okay and clearing it pretty, pretty easily. You just never know. Like it could really set you up for success in a way that you don't, you don't expect. Look, here's the deal. Like the more resilience you can build into your system, the better set up you are when, when the cosmic world sends a curve ball your way. Yeah. Right. It doesn't mean that you may not face serious health challenges at some point for reasons unknown, but the more resilience that's built in the system, the better chance you have of coming out of it in good shape. That may not be a metric up front that you see, but it sure could, you know, it'll pay off. Yeah. Yeah. I think the resilience part is really important. So I think that's probably all we have time for today. Do you want to close us out? Yeah. I mean, listen, these were really good questions. I really hope that this is helpful to all of you folks out there. As Erin said at the beginning, if this was helpful to you and you want us to keep going, then ask more questions on this episode. But frankly, we could just go back to the first of the Bill Lawrence episode and harvest like another, I don't know, we could probably do another 10 episodes of questions. But if you guys enjoyed this and you have more questions, then definitely let us know. Another place to get a lot of your questions answered, I'm going to give a shameless plug to my membership community here and now because I do have a community on Circle and it's filled with really smart people. Like I've got clinicians in there and then just people, just regular folks who are just really interested in all this stuff. And we talk about this in the group all the time and other things all the time. And you get access to me, you know, at least two to three times a month. Like I go in there and do live Q and A's. I bring in podcast guests. Like we do, we do some really cool things in there. So just go to natnidham.com and there's a tab at the top longevity community and you'll see you'll find information there and then like we said we're going to put in the show notes where you can buy bioregulators there's at least three that i can think of that are three suppliers and one shipping out of the u.s one shipping out of europe and the other two are shipping out of europe but profound health hopefully by the time this episode releases will be shipping out of the states there i i i don't know, somehow they got caught in the barbed wire of red tape. These poor people have been working so hard to figure it out. So they're just, they're this close. So we'll see if they've got it together. You can still get them. I've bought them out of state. It's just a little, I mean, it's a few dollars more in shipping, but you can still get them. Well, they have to charge tariffs now too. So it's gotten more expensive. They will be able to bypass the tariffs once they're bringing them in in bulk. So, well, not bypass, but they'll absorb. Somehow there's a difference, but there'll also be codes for you guys in the show notes. So there'll be discount codes and, um, and yeah, that's it. If we have a part two, we may tackle questions. Like people had questions about telomeres. People had questions about, uh, bioregulators and cancer risk, uh, menopause sourcing. We can, we can tell you the sourcing bit cause we'll put that in the notes, but those were some of the other kinds of groupings of questions. So if you're interested in those, definitely let us know. And anything else. Yeah. Yeah. So yeah. And Erin, thank you so much for joining me today. This was so fun. I really enjoyed this. And hopefully you guys enjoyed Erin as much as I did. I love having her come along for the ride. She's awesome. So you can give us your comments on that as well. Go, Erin. Thank you. All right. See you later. Bye. Hey, folks. Just a quick reminder that all of the information presented in this podcast is for information purposes only. No medical advice, no diagnosing, no treatments suggested here. Before you try anything that you hear about or learn about here, make sure that you check with your medical provider.