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The Peter Attia Drive

Podcasts · Health & Fitness

The Peter Attia Drive

261 episodes · 20 with AI analysis

Expert insight on health, performance, longevity, critical thinking, and pursuing excellence. Dr. Peter Attia (Stanford/Hopkins/NIH-trained MD) talks with leaders in their fields.

AI Intelligence · across all analyzed episodes

Topics · top 10

Age-stratified health priorities across life decadesFour horsemen of chronic disease (cardiovascular, cancer, neurodegenerative, metabolic)Dementia prevention strategies and genetic risk factorsDEXA scan screening intervals and interpretationBehavior change and habit formation in health routinesStability training and injury resilienceHigh protein diets and mTOR activationNon-nutritive sweeteners and diet soda evaluationWearable metrics and consumer health data utilityDisease screening and early detection strategies

Analyzed Episodes

Mar 23, 2026

#385 - AMA #82: Applying the tools of longevity in the real world: disease prevention, DEXA scans, artificial sweeteners, injury recovery, stability training, habit formation, protein intake and mTOR activation, and more

Age-stratified health priorities across life decadesFour horsemen of chronic disease (cardiovascular, cancer, neurodegenerative, metabolic)Dementia prevention strategies and genetic risk factors
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Apr 6, 2026

#386 - Aging clocks—what they measure, how they work, and their clinical and real-world relevance

Epigenetic clocks and DNA methylation as aging biomarkersBiological age vs. chronological age vs. pace of agingClinical trial design for longevity interventions
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Apr 13, 2026

#387 - AMA #83: Peptides—evaluating the science, safety, and hype in a rapidly growing field

Peptide mechanism of action evaluation frameworkFDA-approved vs. gray-market peptide therapeuticsPeptide efficacy and safety data assessment
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Apr 20, 2026

#388 — Prostate cancer screening: why current PSA guidelines are failing men and how modern tools improve early detection and save lives

PSA velocity and longitudinal PSA monitoringPSA density and MRI-guided screeningTransperineal vs. transrectal prostate biopsy techniques
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May 18, 2026

#392 - Genetic testing: when it's valuable, how to choose the right test, and what to do with the results

BRCA mutations and hereditary cancer screeningAPOE4 and Alzheimer's disease risk stratificationPharmacogenetics and drug metabolism (CYP2C19, HLA-B*5801)
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May 4, 2026

#390 ‒ AMA #84: Family health history, preventing heart disease, metabolic health, strength training efficiency, dementia risk reduction, NAD supplements, and hydration

Family Health History AssessmentGenetic Testing vs. Family HistoryCardiovascular Disease Prevention
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May 11, 2026

#391 ‒ Colorectal cancer screening: importance of early screening, colonoscopy as a screening and preventive tool, and how to build a personalized strategy

Colorectal cancer screening protocols and intervalsColonoscopy procedure quality and preparationEarly-onset colorectal cancer epidemiology
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Apr 27, 2026

#389 - Thinking scientifically: why it's hard, why it matters, and a practical toolkit

Scientific thinking and epistemologyCognitive biases and social identity in belief formationEvaluating expert credibility and trustworthiness
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Jun 23, 2025

#354 – What the dying can teach us about living well: lessons on life and reflections on mortality | BJ Miller, M.D. and Bridget Sumser, L.C.S.W.

Palliative Care vs. Hospice Care DistinctionsAdvance Directives and Medical Decision-MakingDelirium in End-of-Life Care
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Jun 30, 2025

#355 – Skincare strategies, the science of facial aging, and cosmetic-intervention guidance | Tanuj Nakra, M.D. & Suzan Obagi, M.D.

Facial bone loss and mandibular retrusion in agingHormonal influences on facial fat distribution and skin integrityMineral vs. chemical sunscreen efficacy and safety
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Jul 7, 2025

Navigating bone health: early life influences and advanced strategies for improvement and injury prevention (#214 rebroadcast)

Bone Mineral Density (BMD) screening and DEXA scan interpretation (T-scores and Z-scores)Hip and pelvic fracture mortality risk in aging populationsMenopause and estrogen withdrawal effects on bone remodeling
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Jul 14, 2025

#356 - AMA #73: Preserving brain health, optimizing exercise programming, improving body composition, and more

Dementia and Alzheimer's disease risk factorsModifiable vs. non-modifiable cognitive decline risk factorsApoE4 genotype and genetic predisposition to dementia
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Jul 21, 2025

#357 ‒ A new era of longevity science: models of aging, human trials of rapamycin, biological clocks, promising compounds, and lifestyle interventions | Brian Kennedy, Ph.D.

mTOR signaling and rapamycin dosing strategiesBiological aging clocks and mortality predictionAlpha-ketoglutarate supplementation and lifespan extension
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Jan 5, 2026

#378 ‒ Women's health and performance: how training, nutrition, and hormones interact across life stages | Abbie Smith-Ryan, Ph.D.

Bone health and osteoporosis prevention in childhood and adolescenceMenstrual cycle periodization and training/nutrition strategies across follicular and luteal phasesBody composition measurement and recomposition strategies in midlife women
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Jul 28, 2025

#358 ‒ Peter's takeaways on navigating HRT, rejuvenating the face, understanding the biology of aging, optimizing fertility, and learning to live well from the dying | Quarterly Podcast Summary #6

Male fertility optimization and sperm health assessmentFemale fertility and conception biologyWomen's sexual health and menopause management
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Aug 4, 2025

#359 ‒ How metabolic and immune system dysfunction drive the aging process, the role of NAD, promising interventions, aging clocks, and more | Eric Verdin, M.D.

NAD metabolism and CD38 inhibitionEpigenetic aging clocks and their limitationsThymic involution and immune aging
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Aug 11, 2025

#360 ‒ How to change your habits: why they form and how to build or break them | Charles Duhigg, M.B.A

Habit Formation Science: Cue-Routine-Reward LoopPositive vs. Negative Reinforcement EffectivenessEnvironmental Design for Behavior Change
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Aug 18, 2025

#361 - AMA #74: Sugar and sugar substitutes: weight control, metabolic effects, and health trade-offs

Sugar metabolism and appetite hormonesFructose versus glucose metabolic effectsNon-nutritive sweeteners (saccharin, aspartame, sucralose)
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Sep 1, 2025

Lower back pain: causes, treatment, and prevention of lower back injuries and pain | Stuart McGill, Ph.D. (#287 rebroadcast)

Disc herniation mechanics and delamination progressionFacet joint loading and osteoarthritis cascadeSpinal stenosis and nerve root compression assessment
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Sep 8, 2025

#363 ‒ A new frontier in neurosurgery: restoring brain function with brain-computer interfaces, advancing glioblastoma care, and new hope for devastating brain diseases | Edward Chang, M.D.

Brain-Computer Interfaces (BCIs) for Speech RestorationAwake Brain Surgery and Intraoperative MappingGlioblastoma Treatment and Genomic Profiling
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